Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons

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Publication Type Journal Article
School or College School of Medicine
Department Ophthalmology
Creator Baehr, Wolfgang
Other Author Moon, C; Jaberi, P; Otto-Bruc, A; Palczewski, K; Ronnett, G V
Title Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons
Date 1998
Description The second messengers cAMP and inositol-1,4,5-triphosphate have been implicated in olfaction in various species. The odorant-induced cGMP response was investigated using cilia preparations and olfactory primary cultures. Odorants cause a delayed and sustained elevation of cGMP. A component of this cGMP response is attributable to the activation of one of two kinetically distinct cilial receptor guanylyl cyclases by calcium and a guanylyl cyclase-activating protein (GCAP). cGMP thus formed serves to augment the cAMP signal in a cGMP-dependent protein kinase (PKG) manner by direct activation of adenylate cyclase. cAMP, in turn, activates cAMP-dependent protein kinase (PKA) to negatively regulate guanylyl cyclase, limiting the cGMP signal. These data demonstrate the existence of a regulatory loop in which cGMP can augment a cAMP signal, and in turn cAMP negatively regulates cGMP production via PKA. Thus, a small, localized, odorant-induced cAMP response may be amplified to modulate downstream transduction enzymes or transcriptional events.
Type Text
Publisher Society for Neuroscience
Volume 18
Issue 9
First Page 3195
Last Page 3205
Subject Calcium-Binding Proteins; Nerve Tissue Proteins; Rats, Sprague-Dawley
Subject MESH Guanylate Cyclase; Olfactory Receptor Neurons; Cyclic AMP
Language eng
Bibliographic Citation Moon C, Jaberi P, Otto-Bruc A, Baehr W, Palczewski K, Ronnett GV. (1998). Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J Neurosci, 18(9), 3195-205
Rights Management (c) Society for Neuroscience
Format Medium application/pdf
Identifier ir-main,1722
ARK ark:/87278/s62v3071
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 702618
Reference URL https://collections.lib.utah.edu/ark:/87278/s62v3071
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