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Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis- Application of a High-Precision Manual Estimation Technique

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Title Journal of Neuro-Ophthalmology, September 2011, Volume 31, Issue 3
Date 2011-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6pk3n9m
Setname ehsl_novel_jno
ID 227219
Reference URL https://collections.lib.utah.edu/ark:/87278/s6pk3n9m

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Title Retinal Ganglion Cell Layer Volumetric Assessment by Spectral-Domain Optical Coherence Tomography in Multiple Sclerosis- Application of a High-Precision Manual Estimation Technique
Creator Davies, Emma C; Galetta, Kristin M; Sackel, David J; Talman, Lauren S; Frohman, Elliot M; Calabresi, Peter A; Steven L. Galetta, MD, NYU Langone; Balcer, Laura J
Affiliation Departments of Neurology University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Abstract Neuronal loss in the retina has been demonstrated pathologically in eyes of patients with multiple sclerosis (MS). In vivo, MS eyes have reduced total macular volumes by optical coherence tomography (OCT). Using a high-resolution spectral-domain OCT, this pilot study used a manual method to measure ganglion cell layer (GCL) volumes and to determine the relation of these volumes to visual function in MS eyes.Sixteen eyes of 8 patients with MS and 8 eyes of 5 disease-free control participants were studied using fast macular OCT scans performed with Spectralis OCT (Heidelberg Engineering). Visual function tests of low-contrast letter acuity and high-contrast visual acuity were administered.MS patient eyes had significantly lower GCL volumes than the control eyes (P < 0.001 vs controls, generalized estimating equation regression models accounting for age and within-patient intereye correlations). Within the MS group, eyes with a history of optic neuritis (ON, n = 4) had significantly lower GCL volumes than MS eyes with no ON history (P < 0.001). In contrast to measures of high-contrast visual acuity (P = 0.14), decreased GCL volumes were associated with worse performance on low-contrast letter acuity testing (P = 0.003).This pilot study has characterized thinning of the GCL in MS patient eyes, particularly in those with a history of acute ON, which corresponded to a reduced performance on low-contrast letter acuity testing. Studies utilizing computerized segmentation algorithms will continue to facilitate the detection of GCL loss on a larger scale and provide important information in vivo on the role and timing of neuronal vs axonal loss in MS eyes.
Subject Adult; Diagnostic Techniques, Ophthalmological/standards; Humans; Middle Older people; Multiple Sclerosis/complications; Multiple Sclerosis/pathology; Multiple Sclerosis/physiopathology; Pilot Projects; Prospective Studies; Retinal Degeneration/etiology; Retinal Degeneration/pathology; Retinal Degeneration/physiopathology; Retinal Ganglion Cells/pathology; Tomography, Optical Coherence/methods; Tomography, Optical Coherence/standards
OCR Text Show
Format application/pdf
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Setname ehsl_novel_jno
ID 227211
Reference URL https://collections.lib.utah.edu/ark:/87278/s6pk3n9m/227211