| Title |
Intracranial malignancies occurring more than 20 years after radiation therapy for pituitary adenoma. |
| Creator |
Wu-Chen, Wen Ying; Jacobs, Dina A; Volpe, Nicholas J; Dalmau, Joseph O; Moster, Mark L |
| Affiliation |
Department of Neurology, Temple University Hospital, Philadelphia, Pennsylvania, USA. |
| Abstract |
A 37-year-old woman developed a left third cranial nerve palsy 28 years after radiation for a nonsecreting pituitary adenoma. Imaging disclosed a left parasellar mass and a midbrain/pontine signal abnormality. Biopsy of the parasellar mass revealed a malignant sarcoma. The brainstem abnormality was presumptively diagnosed as a malignant glioma. A 63-year-old man developed a malignant astrocytoma of the left optic nerve and chiasm 23 years after partial excision and radiation of a nonsecreting pituitary adenoma. Both patients died of their malignancies. Although secondary malignancies have been described in this setting, such long latencies have not been reported. |
| Subject |
Adenoma; Adult; Brain Stem Neoplasms; Fatal Outcome; Female; Glioma; Humans; Male; Middle Older people; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Optic Nerve Neoplasms; Pituitary Neoplasms; Time Factors |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
226364 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6vm7jb7/226364 |
