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Esthesioneuroblastoma presenting as sudden unilateral blindness. Histopathologic confirmation of optic nerve demyelination.

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Title Journal of Neuro-Ophthalmology, March 1992, Volume 12, Issue 1
Date 1992-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6j99cgt
Setname ehsl_novel_jno
ID 226071
Reference URL https://collections.lib.utah.edu/ark:/87278/s6j99cgt

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Title Esthesioneuroblastoma presenting as sudden unilateral blindness. Histopathologic confirmation of optic nerve demyelination.
Creator Berman, E.L.; Chu, A.; Wirtschafter, J.D.; Cameron, J.D.; Manivel, J.C.; Duvall, A.J.; Haines, S.J.
Affiliation Department of Ophthalmology, University of Minnesota School of Medicine, Minneapolis.
Abstract We report here a case of esthesioneuroblastoma an 11-year-old girl presenting as acute loss of vision with minimal evidence of orbital, nasal, or paranasal sinus disease, a rare presenting symptom for this tumor. The initial diagnosis was postviral optic neuritis, a pattern of presentation not previously reported. When vision failed to improve, magnetic resonance imaging revealed a lesion in the posterior ethmoid and sphenoid sinuses. After a biopsy, the tumor was excised through the cranium and paranasal sinuses. A mass completely surrounding the optic nerve without invasion was found. Histochemical staining suggested demyelination secondary to compression, confirming the clinical impression of optic neuritis. Anti-Leu 7 monoclonal antibody is useful in characterizing of this tumor, since other immunochemical stains can be misleading. Radiation and chemotherapy were given after the tumor was removed. Two years later, the patient has had neither recurrence nor complications.
Subject Antineoplastic Combined Chemotherapy Protocols; Blindness; Child; Demyelinating Diseases; Female; Humans; Magnetic Resonance Imaging; Neuroectodermal Tumors, Primitive, Peripheral; Optic Nerve Diseases; Paranasal Sinus Neoplasms; Tomography, X-Ray Computed
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Format application/pdf
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890
Setname ehsl_novel_jno
ID 226054
Reference URL https://collections.lib.utah.edu/ark:/87278/s6j99cgt/226054