| Title |
Recurrent Optic Neuritis as the Presenting Manifestation of Primary Hypereosinophilic Syndrome |
| Creator |
Lincoff, NS; Schlesinger, D |
| Affiliation |
State University of New York at Buffalo School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA. Lincoff@acsu.buffalo.edu |
| Abstract |
Two patients sustained multiple attacks of optic neuritis with persistent visual loss. An elevated eosinophil count was initially considered an incidental finding. Years later, the diagnosis of primary hypereosinophilic syndrome (HES) was confirmed by skin and bone marrow in one patient and by lung biopsy in the other. Treatment with hydroxyurea in one patient and with continuous low-dose prednisone in the other stopped the optic neuritis attacks, resolved systemic manifestations, and stabilized neurologic manifestations. These cases emphasize that primary HES may be a cause of recurrent optic neuritis, and that delay in diagnosis and treatment of primary HES can lead to visual morbidity. |
| Subject |
Biopsy; Bone Marrow, pathology; Eosinophils, pathology; Female; Glucocorticoids, therapeutic use; Humans; Hypereosinophilic Syndrome, complications; Hypereosinophilic Syndrome, diagnosis; Hypereosinophilic Syndrome, drug therapy; Leukocyte Count; Magnetic Resonance Imaging; Methylprednisolone, therapeutic use; Middle Older people; Optic Neuritis, diagnosis; Optic Neuritis, drug therapy; Optic Neuritis, etiology; Prednisolone, therapeutic use; Recurrence; Skin, pathology; Visual Fields |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
225463 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6574j3z/225463 |
