| Title |
Sustained Visual Recovery After Treatment with Intrathecal Methotrexate in a Case of Optic Neuropathy Caused by Chronic Lymphocytic Leukemia |
| Creator |
Mowatt, L; Matthews, T; Anderson, L |
| Affiliation |
Sandwell and West Birmingham NHS Trust, Birmingham and Midland Eye Center, Birmingham, England. lillenea@aol.com |
| Abstract |
A 68-year-old woman with chronic lymphocytic leukemia (CLL) had acute optic neuropathy associated with cerebrospinal fluid evidence of meningeal spread of CLL. There was no evidence of a hematologic relapse. After undergoing four weekly doses of intrathecal methotrexate, vision improved dramatically and spinal fluid became normal. Four years later, she has near normal vision in the affected eye and remains in hematologic remission. This is the first reported case of successful treatment of optic neuropathy in CLL with intrathecal methotrexate alone. |
| Subject |
Older people; Antimetabolites, Antineoplastic, administration & dosage; Antimetabolites, Antineoplastic, therapeutic use; Female; Humans; Injections, Spinal; Leukemia, Lymphocytic, Chronic, B-Cell, drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell, physiopathology; Methotrexate, administration & dosage; Methotrexate, therapeutic use; Optic Nerve Neoplasms, drug therapy; Optic Nerve Neoplasms, physiopathology; Recovery of Function; Visual Acuity, physiology; Visual Fields |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
225462 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6574j3z/225462 |
