| Title |
Paraneoplastic Optic Neuropathy and Cerebellar Ataxia with Small Cell Carcinoma of the Lung |
| Creator |
Thambisetty, MR; Scherzer, CR; Yu, Z; Lennon, VA; Newman, NJ |
| Affiliation |
Departments of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA. |
| Abstract |
Bilateral optic neuropathy and subacute cerebellar ataxia were manifestations of a paraneoplastic neurologic disorder in a woman found to have small cell carcinoma of the lung. Serologic tests revealed a neuronal autoantibody specific for CRMP-5, a 62-kd member of the collapsin response-mediating protein family. Unexplained optic neuropathy in the setting of subacute cerebellar ataxia should cause suspicion of a paraneoplastic disorder and prompt testing for this autoantibody, especially in patients at risk for lung carcinoma. |
| Subject |
Older people; Antibodies, Neoplasm/blood; Antigens, Neoplasm/immunology; Autoantibodies/blood; Carcinoma, Small Cell/complications/pathology; Cerebellar Ataxia/diagnosis/etiology/immunology; Fatal Outcome; Female; Humans; Lung Neoplasms/complications/pathology; Nerve Tissue Proteins/immunology; Optic Nerve Diseases/diagnosis/etiology/immunology; Paraneoplastic Syndromes/diagnosis/etiology/immunology; Tumor Markers, Biological/blood |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
225192 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6tx6mg8/225192 |
