The Photoreceptor Cell-Specific Nuclear Receptor is an Autoantigen of Paraneoplastic Retinopathy

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Title Journal of Neuro-Ophthalmology, September 2001, Volume 21, Issue 3
Date 2001-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6tx6mg8
Setname ehsl_novel_jno
ID 225211
Reference URL https://collections.lib.utah.edu/ark:/87278/s6tx6mg8

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Title The Photoreceptor Cell-Specific Nuclear Receptor is an Autoantigen of Paraneoplastic Retinopathy
Creator Eichen, JG; Dalmau, J; Demopoulos, A; Wade, D; Posner, JB; Rosenfeld, MR
Affiliation Department of Neurology and Laboratory of Neuro-Oncology, University of Arkansas for Medical Sciences and the Arkansas Cancer Research Center, Little Rock, Arkansas 72205, USA.
Abstract OBJECTIVES: To report a novel antibody associated with paraneoplastic retinopathy and to characterize the retinal autoantigen. METHODS: Immunohistochemistry of rat and human tissues was used to identify antiretinal antibodies. Serologic screening of a bovine retinal cDNA expression library was performed to clone the target antigen. RESULTS: A 72-year-old woman presented with a 6-month history of progressive visual loss, bilateral central scotomas, light flashes, and night blindness. Visual acuity was 20/40 OD and 20/30 OS. There was generalized loss of retinal pigment and narrow arterioles; discs were normal in appearance. The electroretinogram showed no response. Chest computed tomograph scan demonstrated a right lung mass; biopsy revealed poorly differentiated carcinoma. The patients' serum contained antibodies that immunolabeled nuclei of cells of the outer--and to a lesser extent, the inner--nuclear layer of the adult rat retina. No reactivity was identified with nonretinal adult human or rat tissues. Reactivity was seen in the developing rat embryo. Serologic screening of a bovine retinal library resulted in the isolation of three overlapping clones, encoding a protein highly homologous to the human photoreceptor cell-specific nuclear receptor gene product. CONCLUSIONS: The target antigen of an antibody associated with paraneoplastic retinopathy is the photoreceptor cellspecific nuclear receptor, a member of a conserved family of nuclear receptors involved in photoreceptor cell development or maintenance.
Subject Older people; Animals; Autoantibodies/blood; Autoantigens/immunology; Blotting, Western; Cattle; Female; Humans; Immunoenzyme Techniques; Lung Neoplasms/complications; Paraneoplastic Syndromes/etiology/immunology; Photoreceptors, Vertebrate/immunology; Rats; Receptors, Cytoplasmic and Nuclear/immunology; Retinal Diseases/etiology/immunology; Scotoma/etiology; Transcription Factors/immunology; Vision Disorders/etiology; Visual Acuity
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 225193
Reference URL https://collections.lib.utah.edu/ark:/87278/s6tx6mg8/225193