Paraneoplastic Optic Neuropathy and Cerebellar Ataxia with Small Cell Carcinoma of the Lung

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Title Journal of Neuro-Ophthalmology, September 2001, Volume 21, Issue 3
Date 2001-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6tx6mg8
Setname ehsl_novel_jno
ID 225211
Reference URL https://collections.lib.utah.edu/ark:/87278/s6tx6mg8

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Title Paraneoplastic Optic Neuropathy and Cerebellar Ataxia with Small Cell Carcinoma of the Lung
Creator Thambisetty, MR; Scherzer, CR; Yu, Z; Lennon, VA; Newman, NJ
Affiliation Departments of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Abstract Bilateral optic neuropathy and subacute cerebellar ataxia were manifestations of a paraneoplastic neurologic disorder in a woman found to have small cell carcinoma of the lung. Serologic tests revealed a neuronal autoantibody specific for CRMP-5, a 62-kd member of the collapsin response-mediating protein family. Unexplained optic neuropathy in the setting of subacute cerebellar ataxia should cause suspicion of a paraneoplastic disorder and prompt testing for this autoantibody, especially in patients at risk for lung carcinoma.
Subject Older people; Antibodies, Neoplasm/blood; Antigens, Neoplasm/immunology; Autoantibodies/blood; Carcinoma, Small Cell/complications/pathology; Cerebellar Ataxia/diagnosis/etiology/immunology; Fatal Outcome; Female; Humans; Lung Neoplasms/complications/pathology; Nerve Tissue Proteins/immunology; Optic Nerve Diseases/diagnosis/etiology/immunology; Paraneoplastic Syndromes/diagnosis/etiology/immunology; Tumor Markers, Biological/blood
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 225192
Reference URL https://collections.lib.utah.edu/ark:/87278/s6tx6mg8/225192