| Title |
Myasthenia Gravis with a Paraneoplastic Marker |
| Creator |
Leavitt, JA |
| Affiliation |
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA. |
| Abstract |
Ocular manifestations of myasthenia gravis are very common. Myasthenia gravis may be associated with lung carcinoma. Lambert-Eaton syndrome is also commonly associated with lung carcinoma and can have ocular manifestations. Overlap of these two entities has been described. The case of a patient with fatigable diplopia and ptosis 3 years after removal of a large-cell lung carcinoma is presented. Tests results for acetylcholine receptor binding and modulating antibodies were positive for myasthenia gravis. Test results for presynaptic voltage-gated calcium channel antibodies of the N-type were also positive. However, test results for the P/Q-type voltage-gated calcium channel antibodies, which are consistent with Lambert-Eaton syndrome, were negative. Autoantibodies can be used to serologically distinguish paraneoplastic myasthenia gravis from Lambert-Eaton syndrome. |
| Subject |
Autoantibodies/analysis; Azathioprine/therapeutic use; Biological Markers/analysis; Blepharoptosis/diagnosis; Blepharoptosis/drug therapy; Blepharoptosis/immunology; Calcium Channels/immunology; Carcinoma, Large Cell/pathology; Carcinoma, Large Cell/surgery; Diagnosis, Differential; Diplopia/diagnosis; Diplopia/drug therapy; Diplopia/immunology; Drug Therapy, Combination; Edrophonium/diagnostic use; Humans; Lambert-Eaton Myasthenic Syndrome/diagnosis; Lung Neoplasms/pathology; Lung Neoplasms/surgery; Male; Middle Older people; Myasthenia Gravis/diagnosis; Myasthenia Gravis/drug therapy; Myasthenia Gravis/immunology; Paraneoplastic Syndromes/diagnosis; Paraneoplastic Syndromes/drug therapy; Paraneoplastic Syndromes/immunology; Prednisone/therapeutic use; Receptors, Cholinergic/immunology |
| Format |
application/pdf |
| Publication Type |
Journal Article |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| Setname |
ehsl_novel_jno |
| ID |
225027 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s60p452w/225027 |
