| Description |
Synthetic Lethal with Mss4 1 (Slm1) is a key protein found in the crossroad of the Membrane Compartment of Can1 (MCC) and the Membrane Compartment of TORC2 (MCT). The two compartments on the plasma membrane of budding yeast (Saccharomyces cerevisiae) are responsible for APC transporter regulation and sphingolipid synthesis respectively, altogether maintaining the homeostasis of the plasma membrane. By altering its localization between the MCC and the MCT, Slm1 serves as a signal that communicates the stress condition. And yet, neither the MCC, the MCT, nor Slm1 itself had been reported in the context of mitochondria or metabolism. In this study, we report Slm1 localizes to mitochondria under the combination of glucose starvation and hypo-osmotic stress. We also identified the first 173 amino acids to be critical for such localization. These findings give access to the study of Slm1's role in mitochondrial function, and a stress response pathway that has never been studied before-a pathway that relays stress signals to the regulation of cell metabolism. |
