Contents | 23 of 32

Are We There Yet? Is Neuro-Ophthalmology at the Cuspof a Paradigm Shift? Lessons From Leber Hereditary Optic Neuropathy

Update Item Information
Title Journal of Neuro-Ophthalmology, June 2013, Volume 33, Issue 2
Date 2013-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6mh0vk7
Setname ehsl_novel_jno
ID 227470
Reference URL https://collections.lib.utah.edu/ark:/87278/s6mh0vk7

Page Metadata

Title Are We There Yet? Is Neuro-Ophthalmology at the Cuspof a Paradigm Shift? Lessons From Leber Hereditary Optic Neuropathy
Creator Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USC
Abstract To compare the incidence of cardiac and cerebrovascular events following non-arteritic anterior ischemic optic neuropathy (NAION) compared to published control data using the Framingham, United Kingdom Prospective Diabetes Study (UKPDS) and the National Vascular Disease Prevention Alliance (NVDPA) data. A retrospective study of all consecutive cases of NAION between 1990 and 2005. Patients were stratified into those with or without prior ischemic events and into diabetics and non-diabetics. Outcome measures included cardiovascular morbidity, cerebrovascular events and the Framingham, UKPDS and NVDPA scores for each patient. According to the NVDPA, the average absolute 5-year risk for cardiovascular disease (CVD) was 8.98, compared to 9 CVD events in our study. In the diabetic patients, 5 (17%) had a cardiac event and 2 (8%) had a cerebral vascular accident (CVA). Based on the UKPDS risk calculator, the average 10-year risk for cardiac events is 21.6%, CVA 26.8%. In the non-diabetics, there were 3 cases (7.5% ) of myocardial infarction, compared to the average 10-year Framingham risk for myocardial infarction or coronary death of 11% (8 SD). Following NAION, the incidence of cardiovascular or cerebrovascular events in patients taking aspirin is not in major excess from that expected in risk-factor agematched controls.
Subject Humans; Mitochondria; Neurology; Ophthalmology; Optic Atrophy, Hereditary, Leber; Optic Nerve; Reactive Oxygen Species
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 227460
Reference URL https://collections.lib.utah.edu/ark:/87278/s6mh0vk7/227460
Back to Search Results