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Visual recovery in patients with Leber's hereditary optic neuropathy and the 11778 mutation.

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Title Journal of Neuro-Ophthalmology, March 1992, Volume 12, Issue 1
Date 1992-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6j99cgt
Setname ehsl_novel_jno
ID 226071
Reference URL https://collections.lib.utah.edu/ark:/87278/s6j99cgt

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Title Visual recovery in patients with Leber's hereditary optic neuropathy and the 11778 mutation.
Creator Stone, E.M.; Newman, N.J.; Miller, N.R.; Johns, D.R.; Lott, M.T.; Wallace, D.C.
Affiliation Department of Ophthalmology, University of Iowa College of Medicine, Iowa City.
Abstract Five patients with Leber's hereditary optic neuropathy (LHON) and the 11778 mitochondrial mutation spontaneously recovered 20/40 or better visual acuity in at least one eye after months to years of legal blindness. The patients ranged in age from 9 to 45 years, and the duration of visual loss before recovery ranged from several months to 5.9 years. These patients constitute only about 4% of the 136 affected LHON patients we have studied who also had the 11778 mutation in their mitochondrial DNA. Thus, even though the visual prognosis for most patients with LHON and the 11778 mutation is poor, a few individuals do recover near-normal vision in at least one eye even years after the initial visual loss.
Subject Adolescent; Child; DNA, Mitochondrial; Female; Humans; Male; Middle Older people; Mutation; Optic Atrophies, Hereditary; Remission, Spontaneous; Vision Disorders; Visual Acuity; Visual Fields
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 226049
Reference URL https://collections.lib.utah.edu/ark:/87278/s6j99cgt/226049
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