Galloping Ophthalmoplegia and Numb Chin in Burkitt Lymphoma

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Title Journal of Neuro-Ophthalmology, June 2004, Volume 24, Issue 2
Date 2004-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6jh6s9g
Setname ehsl_novel_jno
ID 225407
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jh6s9g

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Title Galloping Ophthalmoplegia and Numb Chin in Burkitt Lymphoma
Creator Lau, JJC; Okada, CY; Trobe, JD
Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical Center, Ann Arbor, Michigan, USA.
Abstract A 57-year-old man developed complete bilateral ophthalmoplegia over a period of 10 days, together with bilateral facial pain and numbness of the chin. He had no other clinical manifestations. Findings on brain magnetic resonance imaging and spinal fluid formula from the first lumbar puncture were normal, but cerebrospinal fluid flow cytometry disclosed a kappa restriction monoclonal B-cell population, indicating malignant lymphoma. Computed tomography of the chest, abdomen, and pelvis then revealed multiple enlarged lymph nodes. Biopsy of an inguinal node showed findings consistent with Burkitt lymphoma. Within six weeks, intravenous and intrathecal chemotherapy resolved all neurologic findings except a partial right-side sixth nerve palsy and mild chin numbness. Eighteen months after disease onset, the patient remained in remission. Meningeal spread of Burkitt lymphoma is not commonly a presenting feature in immunocompetent adults. Chin numbness, a characteristic feature caused by infiltration of the mental nerve, should facilitate earlier recognition, which may be life saving.
Subject Antimetabolites, Antineoplastic/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Burkitt Lymphoma/cerebrospinal fluid; Burkitt Lymphoma/complications; Burkitt Lymphoma/diagnosis; Burkitt Lymphoma/drug therapy; Chin; Cytarabine/administration & dosage; Humans; Hydrocortisone/administration & dosage; Hypesthesia/etiology; Male; Methotrexate/administration & dosage; Middle Older people; Ophthalmoplegia/etiology; Remission Induction; Tomography, X-Ray Computed
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 225396
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jh6s9g/225396
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