ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue

Update Item Information
Publication Type Journal Article
School or College College of Science
Department Biology
Creator Capecchi, Mario R.
Other Author Westerberg, Rolf; Månsson, Jan-Erik; Golozoubova, Valeria; Shabalina, Irina G.; Backlund, Emma C.; Tvrdik, Petr; Retterstøl, Kjetil; Jacobsson, Anders
Title ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue
Date 2005-12-21
Description During the recruitment process of brown adipose tissue, the mRNA level of the fatty acyl chain elongase Elovl3 is elevated more than 200-fold in cold-stressed mice. We have obtained Elovl3-ablated mice and report here that, although cold-acclimated Elovl3-ablated mice experienced an increased heat loss due to impaired skin barrier, they were unable to hyperrecruit their brown adipose tissue. Instead, they used muscle shivering in order to maintain body temperature. Lack of Elovl3 resulted in a transient decrease in the capacity to elongate saturated fatty acyl-CoAs into very long chain fatty acids, concomitantly with the occurrence of reduced levels of arachidic acid (C20:0) and behenic acid (C22:0) in brown adipose tissue during the initial cold stress. This effect on very long chain fatty acid synthesis could be illustrated as a decrease in the condensation activity of the elongation enzyme. In addition, warmacclimated Elovl3-ablated mice showed diminished ability to accumulate fat and reduced metabolic capacity within the brown fat cells. This points to ELOVL3 as an important regulator of endogenous synthesis of saturated very long chain fatty acids and triglyceride formation in brown adipose tissue during the early phase of the tissue recruitment.
Type Text
Publisher American Society for Biochemistry and Molecular Biology (ASBMB)
Journal Title Journal of Biological Chemistry
Volume 281
Issue 8
First Page 4958
Last Page 4968
DOI 10.1074/jbc.M511588200
citatation_issn 0021-9258
Language eng
Bibliographic Citation Westerberg, R., Månsson, J. E., Golozoubova, V., Shabalina, I. G., Backlund, E. C., Tvrdik, P., Retterstøl, K., Capecchi, M. R., & Jacobsson, A. (2006). ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue. Journal of Biological Chemistry, 281(8), 4958-68.
Rights Management (c)American Society for Biochemistry and Molecular Biology (ASBMB) http://dx.doi.org/10.1074/jbc.M511588200
Format Medium application/pdf
Format Extent 618,157 bytes
Identifier ir-main,9140
ARK ark:/87278/s6v98scv
Setname ir_uspace
ID 704343
Reference URL https://collections.lib.utah.edu/ark:/87278/s6v98scv