Life-threatening reactions to propofol

Update Item Information
Publication Type Journal Article
School or College School of Medicine
Department Neurosurgery
Creator Couldwell, William T.
Other Author Giannotta, Steven L.; Zelman, Vladimir; DeGiorgio, Christopher M.
Title Life-threatening reactions to propofol
Date 1993
Description To the Editor: Propofol (2,6-diisopropyl phenol; Diprivan; Stuart Pharmaceuticals, Wilmington, DE) has been advocated as a titratable continuous infusion anesthetic agent associated with fast and smooth recovery (2, 7). The anesthetic properties of a smooth induction, short half-life, and rapid emergence from anesthesia after prolonged operations, with a low incidence of nausea and vomiting and little "hangover' sedation, suggest that this agent may be ideally suited for use in intracranial neurosurgery (6). It also may be given in combination with analgesics, such as sufentanyl and inhalational agents. Accordingly, we have adopted propofol for use in all cranial base, vascular, and functional neurosurgical procedures. We are currently using propofol (50-100 /ig/kg/min infusion, with a burst suppression dosage of approximately 250 jiig/kg/min used during periods of vascular interruption) in a balanced protocol with narcotic (sufentanyl) and low dosage inhalational (isoflurane) anesthesia.
Type Text
Publisher Wolters Kluwer (LWW)
Volume 33
Issue 6
First Page 1116
Last Page 1117
Subject Propofol; Diprivan
Subject LCSH Anesthetics -- Physiological effect
Subject MESH Anesthetics -- Adverse effects
Language eng
Bibliographic Citation Couldwell, W. T., Giannotta, S. L., Zelman, V., & DeGiorgio, C. M. (1993). Life-threatening reactions to propofol [Letter to the editor]. Neurosurgery, 33(6), 1116-7.
Rights Management (c) Wolters Kluwer (LWW) http://lww.com
Format Medium application/pdf
Format Extent 96,443 bytes
Identifier ir-main,12984
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Reference URL https://collections.lib.utah.edu/ark:/87278/s6t44bj5