| Publication Type |
Journal Article |
| School or College |
School of Medicine; College of Science |
| Department |
Oncological Sciences; Biology; Human Genetics |
| Program |
Institute of Human Genetics; Howard Hughes Medical Institute (HHMI) |
| Creator |
Capecchi, Mario R. |
| Other Author |
Fuchs, Sebastien; Frenzel, Kristen; Hubert, Christine; Lyng, Robert; Muller, Laurent; Michaud, Annie; Xiao, Hong D.; Adams, Jonathan W.; Corvol, Pierre; Shur, Barry D.; Bernstein, Kenneth E |
| Title |
Male fertility is dependent on dipeptidase activity of testis ACE. |
| Date |
2005-11-11 |
| Description |
Testis angiotensin-converting enzyme (ACE) is an isozyme exclusively expressed by developing sperm. This protein has only a single catalytic domain containing the HEXXH consensus-site motif typical of zinc metallopeptidases. The exact role of testis ACE is unknown, but male mice lacking the protein reproduce poorly, despite normal numbers of sperm and normal motility. |
| Type |
Text |
| Publisher |
Nature Publishing Group |
| Volume |
11 |
| Issue |
11 |
| First Page |
1140 |
| Last Page |
1142 |
| Subject |
Amino Acid Motifs; Blotting, Western; Catalytic Domain; Comparative Study; Isoenzymes; Protein Structure, Tertiary |
| Subject MESH |
Fertility; Peptidyl-Dipeptidase A; Testis |
| Language |
eng |
| Bibliographic Citation |
Nat Med. 2005 Nov;11(11):1140-2; author reply 1142-3. Fuchs S, Frenzel K, Hubert C, Lyng R, Muller L, Michaud A, Xiao HD, Adams JW, Capecchi MR, Corvol P, Shur BD, Bernstein KE. Male fertility is dependent on dipeptidase activity of testis ACE. Retrieved on November 2, 2006 from http://www.nature.com/nm/journal/v11/n11/abs/nm1105-1140.html. |
| Rights Management |
copyright ? 2005 Nature Publishing Group. All Rights Reserved. |
| Format Medium |
application/pdf |
| Identifier |
ir-main,556 |
| ARK |
ark:/87278/s6t44bg8 |
| Setname |
ir_uspace |
| ID |
704793 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6t44bg8 |
