A new framework for analyzing white matter maturation in early brain development

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Publication Type pre-print
School or College <blank>
Department <blank>
Creator Gerig, Guido
Other Author Prastawa, Marcel; Sadeghi, Neda; Gilmore, John H.; Lin, Weili
Title A new framework for analyzing white matter maturation in early brain development
Date 2010-01-01
Description The trajectory of early brain development is marked by rapid growth presented by volume but also by tissue property changes. Capturing regional characteristics of axonal structuring and myelination via neuroimaging requires analysis of longitudinal image data with multiple modalities. Complementary to earlier studies of volume and cortical folding analysis, this paper focuses on white matter tissue changes as seen in multimodal MRI and DTI. We propose a new framework for analyzing early maturation in white matter that generates a normative spatiotemporal model and provides 3D maps of absolute and relative indices of maturation. The method, using a continuous model of intensity changes using modified Legendre polynomials, has been applied to a multimodal dataset (T1W, T2W, PD, DTI) with 8 subjects that have been scanned at approximately 2 weeks, 1 year, and 2 years. We demonstrate that spatial maturation maps generated from different modalities capture different properties of white matter growth which might lead to a better understanding of the underlying neurobiology.
Type Text
Publisher Institute of Electrical and Electronics Engineers (IEEE)
First Page 97
Last Page 100
Language eng
Bibliographic Citation Prastawa, M. W., Sadeghi, N., Gilmore, J. H., Lin, W., & Gerig, G. (2010). A new framework for analyzing white matter maturation in early brain development. Proceedings of the 2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 97-100.
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Identifier uspace,19212
ARK ark:/87278/s6sf659h
Setname ir_uspace
Date Created 2015-01-30
Date Modified 2021-05-06
ID 712798
Reference URL https://collections.lib.utah.edu/ark:/87278/s6sf659h