LIM proteins in actin cytoskeleton mechanoresponse

Update Item Information
Publication Type pre-print
School or College College of Science
Department Biology
Creator Beckerle, Mary C.
Other Author Smith, M. A.; Hoffman, L. M.
Title LIM proteins in actin cytoskeleton mechanoresponse
Date 2014-01-01
Description The actin cytoskeleton assembles into branched networks or bundles to generate mechanical force for critical cellular processes such as establishment of polarity, adhesion, and migration. Stress fibers are contractile, actomyosin structures that physically couple to the extracellular matrix through integrin-based focal adhesions, thereby transmitting force into and across the cell. Recently, LIM domain proteins have been implicated in mediating this cytoskeletal mechanotransduction. Among the more well studied LIM domain adapter proteins is zyxin, a dynamic component of both focal adhesions and stress fibers. Here, we discuss recent research detailing the mechanisms by which stress fibers adjust their structure and composition to balance mechanical forces, and suggest ways zyxin and other LIM domain proteins mediate mechanoresponse.
Type Text
Publisher Elsevier
Volume 24
Issue 10
First Page 575
Last Page 583
Language eng
Bibliographic Citation Smith, M. A., Hoffman, L. M., & Beckerle, M. C. (2014). LIM proteins in actin cytoskeleton mechanoresponse. Trends in Cell Biology, 24(10), 575-83.
Rights Management (c) Elsevier ; Authors manuscript from Smith, M. A., Hoffman, L. M., & Beckerle, M. C. (2014). LIM proteins in actin cytoskeleton mechanoresponse. Trends in Cell Biology, 24(10), 575-83. http://dx.doi.org/10.1016/j.tcb.2014.04.009
Format Medium application/pdf
Format Extent 8,737,602 bytes
Identifier uspace,19060
ARK ark:/87278/s6rr57b6
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Reference URL https://collections.lib.utah.edu/ark:/87278/s6rr57b6