ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes

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Publication Type Journal Article
School or College School of Medicine; College of Health
Department Internal Medicine; Exercise & Sport Science; Physical Therapy; Nutrition; Family & Preventive Medicine
Creator Hunt, Steven C.; Adams, Ted; Hopkins, Paul N.; Hunt, Steven C.
Other Author Schoenborn, Veit; Heid, Iris M.; Vollmert, Caren; Lingenhel, Arno; llig, Thomas; Zimmermann, Robert; Zechner, Rudolf; Kronenberg, Florian
Title ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes
Date 2006
Description Adipose triglyceride lipase (ATGL) was recently described to predominantly perform the initial step in triglyceride hydrolysis and therefore seems to play a pivotal role in the lipolytic catabolism of stored fat in adipose tissue. In the first study investigating genetic variations within the ATGL gene in humans, 12 polymorphisms identified via sequencing and database search were studied in 2,434 individuals of European ancestry from Utah. These polymorphisms and their haplotypes were analyzed in subjects not taking diabetes medication for association with plasma free fatty acids (FFAs) as primary analysis, as well as triglycerides and glucose as a secondary analysis (n = 1,701, 2,193, or 2,190, respectively). Furthermore, type 2 diabetes (n = 342 of 2,434) was analyzed as an outcome. FFA concentrations were significantly associated with several single nucleotide polymorphisms (SNPs) of ATGL (P values from 0.015 to 0.00003), consistent with additive inheritance. The pattern was similar when considering triglyceride concentrations. Furthermore, two SNPs showed associations with glucose levels (P < 0.00001) and risk of type 2 diabetes (P < 0.05). Haplotype analysis supported and extended the shown SNP association analyses. These results complement previous findings of functional studies in mammals and elucidate a potential role of ATGL in pathways involved in components of the metabolic syndrome.
Type Text
Publisher American Diabetes Association
Volume 55
Issue 5
First Page 1270
Last Page 1275
Subject Diabete, Type 2; ATGL; Fat; Triglycerides
Subject MESH Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Lipase
Language eng
Bibliographic Citation Schoenborn V, Heid IM, Vollmert C, Lingenhel A, Adams TD, Hopkins PN, Illig T, Zimmermann R, Zechner R, Hunt SC, Kronenberg F. (2006) The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. Diabetes, 55(5):1270-5
Rights Management (c) American Diabetes Association
Format Medium application/pdf
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