N-formylmethionyl-sRNA as the initiator of protein synthesis.

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Publication Type Journal Article
School or College College of Science; School of Medicine
Department Oncological Sciences; Biology; Human Genetics
Program Institute of Human Genetics; Howard Hughes Medical Institute (HHMI)
Creator Capecchi, Mario R.
Other Author Adams, Jerry M
Title N-formylmethionyl-sRNA as the initiator of protein synthesis.
Date 1966-01-01
Description A bizarre fast about Nterminal groups of bacterial proteins. Instead of a random mixture, that the great majority of N-terminal groups were either methionine or alanine. This finding suggested that methionine and alanine constituted start signals for the initiation of polypeptide chains. Alternatively, the remaining amino acids were not detected because of acylation of their amino roups. The discovery of Nformylmethionyl-sRNA provided a means for furtherstudy of the problem.
Type Text
Publisher National Academy of Sciences of the United States of America.
Volume 55
Issue 1
First Page 147
Last Page 155
Subject Electrophoresis; Formates; In Vitro; Methionine
Subject MESH Bacterial Proteins; Escherichia coli; RNA, Bacterial; RNA, Transfer
Language eng
Bibliographic Citation Proc Natl Acad Sci U S A. 1966 Jan;55(1):147-55. Adams JM, Capecchi MR. N-formylmethionyl-sRNA as the initiator of protein synthesis. Retrieved on September 14, 2006 from http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=5328638.
Rights Management Copyright 1966 National Academy of Sciences of the United States of America. All right Reserved
Format Medium application/pdf
Identifier ir-main,393
ARK ark:/87278/s6qv4507
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 706015
Reference URL https://collections.lib.utah.edu/ark:/87278/s6qv4507