| Publication Type |
journal article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M. |
| Other Author |
Ferro, Ari M. |
| Title |
Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus |
| Date |
1984 |
| Description |
We demonstrate that the activity of the major DNA topoisomerase I from calf thymus is severely inhibited after modification by purified poly(ADP-ribose) synthetase. Polymeric chains of poly(ADP-ribose) are covalently attached to DNA topoisomerase I. These observations with highly purified enzymes suggest that poly(ADP-ribosylation) may be a cellular mechanism for modulating DNA topoisomerase I activity in response to the state of DNA in the nucleus. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
259 |
| Issue |
1 |
| First Page |
547 |
| Last Page |
554 |
| Subject |
ADP-ribosylation; Poly(ADP-ribose) synthetase |
| Subject LCSH |
DNA topoisomerases; Ligases |
| Language |
eng |
| Bibliographic Citation |
Ferro, A. M., & Olivera, B. M. (1984). Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus. Journal of Biological Chemistry, 259(1), 547-54. |
| Rights Management |
©American Society for Biochemistry and Molecular Biology |
| Format Medium |
application/pdf |
| Format Extent |
4,949,173 bytes |
| Identifier |
ir-main,8201 |
| ARK |
ark:/87278/s6nk3zbg |
| Setname |
ir_uspace |
| ID |
704184 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6nk3zbg |
