Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus

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Publication Type Journal Article
School or College College of Science
Department Biology
Creator Olivera, Baldomero M.
Other Author Ferro, Ari M.
Title Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus
Date 1984
Description We demonstrate that the activity of the major DNA topoisomerase I from calf thymus is severely inhibited after modification by purified poly(ADP-ribose) synthetase. Polymeric chains of poly(ADP-ribose) are covalently attached to DNA topoisomerase I. These observations with highly purified enzymes suggest that poly(ADP-ribosylation) may be a cellular mechanism for modulating DNA topoisomerase I activity in response to the state of DNA in the nucleus.
Type Text
Publisher American Society for Biochemistry and Molecular Biology (ASBMB)
Volume 259
Issue 1
First Page 547
Last Page 554
Subject ADP-ribosylation; Poly(ADP-ribose) synthetase
Subject LCSH DNA topoisomerases; Ligases
Language eng
Bibliographic Citation Ferro, A. M., & Olivera, B. M. (1984). Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus. Journal of Biological Chemistry, 259(1), 547-54.
Rights Management (c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/
Format Medium application/pdf
Format Extent 4,949,173 bytes
Identifier ir-main,8201
ARK ark:/87278/s6nk3zbg
Setname ir_uspace
ID 704184
Reference URL https://collections.lib.utah.edu/ark:/87278/s6nk3zbg