Elevated second-trimester maternal serum hCG: a marker of inadequate angiogenesis.

Update item information
Publication Type Journal Article
School or College School of Medicine
Department Pediatrics; Obstetrics & Gynecology
Creator Varner, Michael W.
Other Author Spong, Catherine Y.; Ghidini, Alessandro; Dildy, Gary A.; Loucks, Carol A.; Pezzullo, John C.
Title Elevated second-trimester maternal serum hCG: a marker of inadequate angiogenesis.
Date 1998-04
Description OBJECTIVE: To measure angiogenin, a potent inducer of neovascularization and interleukin-6, as an indicator of acute inflammation, in second-trimester amniotic fluid of patients with elevated maternal serum hCG. METHODS: In this case-control study, 20 patients with elevated maternal serum hCG (at least 2.0 multiples of median) at triple screen were matched 2:1 with controls on the basis of year of amniocentesis, parity, and race. Inclusion criteria were 1) singleton gestation, 2) no evidence of anomalies, and 3) genetic amniocentesis. Amniotic fluid was immunoassayed for angiogenin and interleukin-6. The immunoassay sensitivity for angiogenin was 0.026 ng/mL, interassay coefficient of variation 4.6%, and intra-assay coefficient of variation 2.9%. For interleukin-6, the immunoassay sensitivity was 2.37 pg/mL, interassay coefficient of variation 2.7%, and intra-assay coefficient of variation 1.9%. Angiogenin and interleukin-6 values were normalized by using natural log transformation for statistical analysis. Statistical analysis included analysis of variance and stepwise regression, with P < .05 significant. RESULTS: After correcting (by multivariate regression) for gestational age at sampling and nulliparity, amniotic fluid angiogenin levels were significantly lower in the study subjects than in controls (26%+/-11% lower, P=.004), whereas the interleukin-6 levels did not change significantly (34%+/-40% lower, P=.3). CONCLUSION: Amniotic fluid angiogenin levels are significantly lower in patients with elevated maternal serum hCG at triple screen, suggesting inadequate angiogenesis, but interleukin-6 values do not differ significantly.
Type Text
Publisher Lippincott, Williams & Wilkins
Volume 91
Issue 4
First Page 605
Last Page 608
Subject Angiogenesis Inducing Agents; Interleukin-6; Pregnancy Complications; hCG
Subject MESH Amniotic Fluid; Angiogenesis Inducing Agents; Chorionic Gonadotropin; Interleukin-6; Pregnancy Trimester, Second
Language eng
Bibliographic Citation Spong CY, Ghidini A, Dildy GA, Loucks CA, Varner MW, Pezzullo JC. Elevated second-trimester maternal serum hCG: a marker of inadequate angiogenesis. Obstet Gynecol. 1998 Apr;91(4):605-8. Retroeved on April 19, 2007 from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?orig_db=PubMed&db=PubMed&cmd=Search&term=91%5Bvolume%5D+AND+4%5Bissue%5D+AND+605%5Bpage%5D+AND+1998%5Bpdat%5D+AND+Varner+MW%5Bauthor%5D
Rights Management Copyright © Wolters Kluwer, Obstetrics and Gynecology, 91, 605-8, 1998
Format Medium application/pdf
ARK ark:/87278/s6k36c0n
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 704496
Reference URL https://collections.lib.utah.edu/ark:/87278/s6k36c0n