| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. Michael |
| Other Author |
Jacobsen, Richard; Yoshikami, Doju; Ellison, Michael; Martinez, Jennifer; Cartier, G. Edward; Shon, Ki-Joon; Groebe, Duncan R.; Abramson, Stewart N. |
| Title |
Differential targeting of nicotinic acetylcholine receptors by novel αA-conotoxins |
| Date |
1997 |
| Description |
We describe the isolation and characterization of two peptide toxins from Conus ermineus venom targeted to nicotinic acetylcholine receptors (nAChRs). The peptide structures have been confirmed by mass spectrometry and chemical synthesis. In contrast to the 12-18 residue, 4 Cys-containing α-conotoxins, the new toxins have 30 residues and 6 Cys residues. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
272 |
| Issue |
36 |
| First Page |
22531 |
| Last Page |
22537 |
| Subject |
Conotoxins; aA-conotoxins; Conus ermineus; Peptide toxins |
| Subject LCSH |
Conus; Marine toxins; Nicotinic receptors -- Antagonists |
| Language |
eng |
| Bibliographic Citation |
Jacobsen, R., Yoshikami, D., Ellison, M., Martinez, J., Gray, W. R., Cartier, G. E., Shon, K.-J., Groebe, D. R., Abramson, S. N., Olivera, B. M., & McIntosh, J. M. (1997). Differential targeting of nicotinic acetylcholine receptors by novel αA-conotoxins. Journal of Biological Chemistry, 272(36), 22531-37. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
430,071 bytes |
| Identifier |
ir-main,8364 |
| ARK |
ark:/87278/s6gb2nbd |
| Setname |
ir_uspace |
| ID |
704109 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6gb2nbd |
