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Show Joumal of Clinical Neuro-ophthalmology 13(3): 207-217, 1993. Literature Abstracts Foveal Cone Electroretinograms in Patients with Central Visual Loss of Unexplained Etiology. Matthews GP, Sandberg MA, Berson EL. Arch Ophthalmol 1992;110:1568-70 (Nov). [Reprint requests to Dr, M. A. Sandberg, Berman-Gund Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St., Boston, MA 02114.] Five patients ranging in age from 24 to 66 years who had decreased central vision without visible retinal abnormalities were studied with foveal cone electroretinography and found to have reduced amplitudes. The authors believe these patients have a form of macular degeneration. Lyn A. Sedwick, M.D. Leber's Hereditary Optic Neuropathy. Clinical Manifestations of the 3460 Mutation. Johns DR, Smith KH, Miller NR. Arch Ophthalmol 1992;110: 1577-81 (Nov). [Reprint requests to Dr. D. R. Johns, Department of Neurology, The Johns Hopkins Hospital, Meyer 6-119, 600 N Wolfe St, Baltimore, MD 21205.] Dr. Johns and colleagues described "clinical characteristics of 12 visually symptomatic patients from nine families with the 3460 mutation" and compared these to patients reported with the 11778 mutation. The 3460 patients have a higher percentage of spontaneous visual recovery (20% vs 4%) and more pedigrees with more than one affected family member. Leber-o-philes will enjoy this cogent article, both for its facts and its theories. Lyn A. Sedwick, M.D. Optic Nerve Aplasia. Margo eE, Hamed LM, Fang E, Dawson WW. Arch Ophthalmol 1992;110:1610-3 (Nov). [Reprints not available.] A 3-year-oId girl with monocular microphthalmos was found to have optic nerve aplasia, both on histopathology postenucleation and then fol- 207 © 1993 Raven Press, Ltd., New York low-up magnetic resonance scanning. Visually evoked response demonstrated increased signal from the cerebral cortex ipsilateral to the optic nerve aplasia, which suggests abnormal rerouting of temporal retinal fibers from the normal eye, similar to the anomalous visually evoked response seen in albinism. The authors discuss the relation between the optic nerve aplasia and abnormal cortical innervation in this patient. Lyn A. Sedwick, M.D. Acquired Immunodeficiency Syndrome-Related Primary Intraocular Lymphoma. Stanton CA, Sloan III DB, Slusher MM, Greven CM. Arch OphthalmoI1992; 110:1614-7 (Nov). [Reprint requests to Dr. C. M. Greven, Department of Ophthalmology, Bowman Gray School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1033.] A 37-year-old man with AIDS developed vitritis and multiple enhancing brain lesions on magnetic resonance. Ante mortem lumbar puncture and brain biopsy were nondiagnostic, although vitrectomy suggested lymphoma. Autopsy confirmed central nervous system and ocular lymphoma. Lyn A. Sedwick, M.D. Pediatric Pseudotumor Cerebri (Idiopathic Intracranial Hypertension). Lessell S. Surv Ophthalmol 1992;37:155-66 (Nov-Dec). [Reprint requests to Dr. S. Lessell, 243 Charles St., Boston, MA 02114.] Dr. Lessell offers an entertaining and exhaustive review of reports, cases, and causes of pseudotumor cerebri in children. Infantile and pediatric cases have a presentation and evaluation which is distinct from adults, and which is clearly presented in this article. Lyn A. Sedwick, M.D. |
