Publication Type |
Journal Article |
School or College |
College of Science |
Department |
Biology |
Creator |
Beckerle, Mary C. |
Other Author |
Zhao, Marike Koedood; Wang, Yuan; Murphy, Kerry; Yi, Jinseong; Gilmore, Thomas D. |
Title |
LIM domain-containing protein Trip6 can act as a coactivator for the v-Rel transcription factor |
Date |
1999 |
Description |
The retroviral oncoprotein v-Rel is a transcriptional activator in the Rel/NF-KB family of eukaryotic transcription factors. v-Rel malignantly transforms a variety of cell types in vitro and in vivo, and its transforming activity is dependent on the ability of v-Rel to bind to DNA and activate transcription. In this report, we used the yeast two-hybrid assay to identify proteins that interact with C-terminal sequences of v-Rel that are needed for transcriptional activation and transformation. One protein, Trip6, that we identified in this screen was previously identified as a thyroid hormone receptor-interacting protein. |
Type |
Text |
Publisher |
Cognizant Communication Corporation |
Volume |
8 |
First Page |
207 |
Last Page |
217 |
Subject |
LIM domains; Oncoproteins; v-Rel; Retroviral oncogene; Trip6; Coactivator; Malignant transformation; NF-kB; Two-hybrid assay |
Subject LCSH |
Transcription factors; Viral proteins; DNA-binding proteins |
Dissertation Institution |
University of Utah |
Language |
eng |
Bibliographic Citation |
Zhao, M. K., Wang, Y., Murphy, K., Yi, J., Beckerle, M. C., & Gilmore, T. D. (1999). LIM domain-containing protein Trip6 can act as a coactivator for the v-Rel transcription factor. Gene Expression, 8, 207-17. |
Rights Management |
(c)Cognizant Communication Corporation |
Format Medium |
application/pdf |
Format Extent |
816,206 bytes |
Identifier |
ir-main,6523 |
ARK |
ark:/87278/s6dz0spc |
Setname |
ir_uspace |
ID |
704767 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6dz0spc |