Publication Type |
Journal Article |
School or College |
College of Science |
Department |
Biology |
Creator |
Capecchi, Mario R. |
Other Author |
Cole, Justin M.; Khokhlova, Nata; Sutliff, Roy L.; Adams, Jonathan W.; Disher, Kevin M.; Zhao, Hui; Corvol, Pierre; Bernstein, Kenneth E. |
Title |
Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II |
Date |
2003 |
Description |
Recently, the concept of local renin-angiotensin systems (RAS) capable of generating angiotensin II apart from the circulation has received considerable attention. To investigate this, we generated ACE 1/3 mice in which one allele of ACE is null and the second allele was engineered to express ACE on the surface of hepatocytes. ACE 1/3 mice express no endothelial ACE and lack ACE within the lungs. Their kidneys contain <7.8% the enzyme levels present in control mice. Plasma conversion of angiotensin I to angiotensin II was 43.3% normal. The baseline blood pressure and renal function of the ACE 1/3 mice were normal, probably as a function of a marked increase of both plasma angiotensin I and angiotensin II. When exposed to 2 weeks of a salt-free diet (a stress diet stimulating the RAS), blood pressure in ACE 1/3 mice decreased to 92.3+2.0 mm Hg, a level significantly lower than that of wild-type control mice. The ACE 1/3 mice demonstrate the plasticity of the RAS and show that significant compensation is required to maintain normal, basal blood pressure in a mouse with an impaired local vascular and renal RAS. (Hypertension. 2003;41:313- 321.) |
Type |
Text |
Publisher |
American Heart Association |
Volume |
41 |
First Page |
313 |
Last Page |
321 |
Dissertation Institution |
University of Utah |
Language |
eng |
Bibliographic Citation |
Cole J. M., Khokhlova, N., Sutliff, R. L., Adams, J. W., Disher, K. M., Zhao, H., Capecchi, M. R., Corvol, P., & Bernstein, K. E. (2003). Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II. Hypertension, 41, 313-21. |
Rights Management |
(c)American Heart Association http://www.ahajournals.org/ |
Format Medium |
application/pdf |
Format Extent |
162,664 bytes |
Identifier |
ir-main,9117 |
ARK |
ark:/87278/s6db8kfk |
Setname |
ir_uspace |
ID |
706448 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6db8kfk |