| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. Michael |
| Other Author |
Rivier, Jean; Galyean, Robert; Azimi-Zonooz, Aryan; Cruz, Lourdes J. |
| Title |
Neuronal calcium channel inhibitors: synthesis of ω-conotoxin GVIA and effects on 45Ca-uptake by synaptosomes |
| Date |
1987 |
| Description |
We previously described a 27-amino acid peptide neurotoxin from the venom of Conus geographus, wconotoxin GVIA, which inhibits neuronal voltage-activated calcium channels. In this paper we describe the total synthesis of ω-conotoxin GVIA and demonstrate that it efficiently blocks voltage-activated uptake of 46Ca by standard synaptosomal preparations from chick brain. Dihydropyridines do not block 46Ca uptake under these conditions. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
262 |
| Issue |
3 |
| First Page |
1194 |
| Last Page |
1198 |
| Subject |
Neuronal calcium; Calcium channels; Channel inhibitors; [omega]-conotoxin GVIA |
| Subject LCSH |
Calcium in the body; Neurotoxic agents; Synaptosomes |
| Language |
eng |
| Bibliographic Citation |
Rivier, J., Galyean, R., Gray, W. R., Azimi-Zonooz, A., McIntosh, J. M., Cruz, L. J., & Olivera, B. M. (1987). Neuronal calcium channel inhibitors: synthesis of ω-conotoxin GVIA and effects on 45Ca-uptake by synaptosomes. Journal of Biological Chemistry, 262(3), 1194-98. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
648,116 bytes |
| Identifier |
ir-main,8232 |
| ARK |
ark:/87278/s69p3k0c |
| Setname |
ir_uspace |
| ID |
704675 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s69p3k0c |
