Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice

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Publication Type Journal Article
School or College College of Science
Department Biology
Creator Capecchi, Mario R.
Other Author Cole, Justin; Ertoy, Dilek; Lin, Hsinchen; Sutliff, Roy L.; Ezan, Eric; Guyene, Tham T.; Corvol, Pierre; Bernstein, Kenneth E.
Title Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice
Date 2000
Description While nephrologists often observe reduced hematocrit associated with inhibitors of angiotensin-converting enzyme (ACE), the basis for this effect is not well understood. We now report that two strains of ACE knockout mice have a normocytic anemia associated with elevated plasma erythropoietin levels. 51Cr labeling of red cells showed that the knockout mice have a normal total blood volume but a reduced red cell mass. ACE knockout mice, which lack tissue ACE, are anemic despite having normal renal function. These mice have increased plasma levels of the peptide acetyl-SDKP, a possible stem cell suppressor. However, they also show low plasma levels of angiotensin II. Infusion of angiotensin II for 2 weeks increased hematocrit to near normal levels. These data suggest that angiotensin II facilitates erythropoiesis, a conclusion with implications for the management of chronically ill patients on inhibitors of the renin-angiotensin system.
Type Text
Publisher The American Society for Clinical Investigation (ASCI)
Volume 106
First Page 1391
Last Page 1398
Dissertation Institution University of Utah
Language eng
Bibliographic Citation Cole, J., Ertoy, D., Lin, H., Sutliff, R. L., Ezan, E., Guyene, T. T., Capecchi, M. R., Corvol, P., & Bernstein, K. E. (2000). Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. Journal of Clinical Investigation, 106, 1391-8.
Rights Management (c)American Society for Clinical Investigation
Format Medium application/pdf
Format Extent 686,567 bytes
Identifier ir-main,9086
ARK ark:/87278/s69c7fnn
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Reference URL https://collections.lib.utah.edu/ark:/87278/s69c7fnn