Measures for validation of DTI tractography

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Publication Type pre-print
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Creator Gerig, Guido
Other Author Gouttard, Sylvain.; Goodlett, Casey B.; Kubicki, Marek
Title Measures for validation of DTI tractography
Date 2012-01-01
Description The evaluation of analysis methods for diffusion tensor imaging (DTI) remains challenging due to the lack of gold standards and validation frameworks. Significant work remains in developing metrics for comparing fiber bundles generated from streamline tractography. We propose a set of volumetric and tract oriented measures for evaluating tract differences. The different methods developed for this assessment work are: an overlap measurement, a point cloud distance and a quantification of the diffusion properties at similar locations between fiber bundles. The application of the measures in this paper is a comparison of atlas generated tractography to tractography generated in individual images. For the validation we used a database of 37 subject DTIs, and applied the measurements on five specific fiber bundles: uncinate, cingulum (left and right for both bundles) and genu. Each measurments is interesting for specific use: the overlap measure presents a simple and comprehensive metric but is sensitive to partial voluming and does not give consistent values depending on the bundle geometry. The point cloud distance associated with a quantile interpretation of the distribution gives a good intuition of how close and similar the bundles are. Finally, the functional difference is useful for a comparison of the diffusion properties since it is the focus of many DTI analysis to compare scalar invariants. The comparison demonstrated reasonable similarity of results. The tract difference measures are also applicable to comparison of tractography algorithms, quality control, reproducibility studies, and other validation problems.
Type Text
Publisher International Society for Optical Engineering (SPIE)
Volume 8314
Issue 1
First Page 83140J-1
Last Page 83140J-6
Language eng
Bibliographic Citation Gouttard, S., Goodlett, C. B., Kubicki, M., & Gerig, G. (2012). Measures for validation of DTI tractography. Proceedings of Medical Imaging 2012: Image Processing, 8314(1), 83140J-1-83140J-6.
Rights Management (c)Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. 10.1117/12.911546.
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Date Created 2015-01-12
Date Modified 2021-05-06
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