| Identifier |
Nonspecific_Orbital_Inflammation_NOVEL |
| Title |
Nonspecific Orbital Inflamation |
| Creator |
Kaylyn Mattick; Michael Han; Priyanka Iyer; Maria Del Valle Estopinal; Lilangi S. Ediriwickrema |
| Affiliation |
(KM) UC Irvine Health, Gavin Herbert Eye Institute; (MH) (LSE) University of California, Irvine, Ophthalmology; (PI) University of California, Irvine, Rheumatology; (MDE) University of California, Irvine, Ophthalmology, Pathology |
| Subject |
Idiopathic Orbital Inflammation; IOI; Nonspecific Orbital Inflammation; NSOI; Orbital Pseudotumor |
| Description |
Nonspecific orbital inflammation (NSOI), also known as idiopathic orbital inflammation or orbital pseudotumor, is a chronic, inflammatory condition that affects the orbit and the surrounding structures. It can mimic other disease processes such as malignancy or infection and should thus be worked up to rule out other, more severe conditions. In this chapter, we discuss the etiology of NSOI, its prevalence and affected populations, and its common clinical features. Furthermore, we explain diagnostic tools for evaluation, differential diagnoses, and treatment of NSOI. |
| Date |
2025-08 |
| References |
1. Eshraghi B, Sonbolestan SA, Abtahi MA, Mirmohammadsadeghi A. Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation. J Curr Ophthalmol. 2019;31(3):327-334. doi:10.1016/j.joco.2019.03.004. 2. Ronquillo Y, Zeppieri M, Patel BC. Nonspecific Orbital Inflammation. In: StatPearls. StatPearls Publishing; 2024. Accessed July 22, 2024. http://www.ncbi.nlm.nih.gov/books/NBK551576/. 3. Yuen SJA, Rubin PAD. Idiopathic Orbital Inflammation: Distribution, Clinical Features, and Treatment Outcome. Arch Ophthalmol. 2003;121(4):491-499. doi:10.1001/archopht.121.4.491. 4. Espinoza GM. Orbital Inflammatory Pseudotumors: Etiology, Differential Diagnosis, and Management. Curr Rheumatol Rep. 2010;12(6):443-447. doi:10.1007/s11926-010-0128-8. 5. Jacobs D, Galetta S. Diagnosis and management of orbital pseudotumor. Curr Opin Ophthalmol. 2002;13(6):347. 6. Gordon LK. Orbital inflammatory disease: a diagnostic and therapeutic challenge. Eye. 2006;20(10):1196-1206. doi:10.1038/sj.eye.6702383. 7. Aryasit O, Tiraset N, Preechawai P, Kayasut K, Sanghan N, Sittivarakul W. IgG4-related disease in patients with idiopathic orbital inflammation. BMC Ophthalmol. 2021;21:356. doi:10.1186/s12886-021-02115-x. 8. Chiu CS, Rubin PAD. Pharmacotherapies and Nonpharmacotherapies for Orbital Inflammatory Diseases. Int Ophthalmol Clin. 2004;44(3):165. 9. Weber AL, Romo LV, Sabates NR. PSEUDOTUMOR OF THE ORBIT: Clinical, Pathologic, and Radiologic Evaluation. Radiol Clin North Am. 1999;37(1):151-168. doi:10.1016/S0033-8389(05)70084-1. 10. Raskin EM, McCormick SA, Maher EA, Della Rocca RC. Granulomatous idiopathic orbital inflammation. Ophthal Plast Reconstr Surg. 1995;11(2):131-135. doi:10.1097/00002341-199506000-00010. 11. Chaia-Semerena GM, Vargas-Camaño ME, Alonso-Bello CD, et al. The Effects of Alternate-Day Corticosteroids in Autoimmune Disease Patients. Autoimmune Dis. 2020;2020:8719284. doi:10.1155/2020/8719284. 12. Lim L, Suhler EB, Smith JR. Biologic therapies for inflammatory eye disease. Clin Experiment Ophthalmol. 2006;34(4):365-374. doi:10.1111/j.1442-9071.2006.01225.x |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NOVEL https://NOVEL.utah.edu |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2025. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6896acv |
| Setname |
ehsl_novel_novel |
| ID |
2889170 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6896acv |
