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Show 292 LITERATURE ABSTRACTS Leber's Hereditary Optic Neuropathy. Clinical Manifestations of the 15257 Mutation. Johns DR, Smith KH, Savino PJ, Miller NR. Ophthalmology 1993;100:981-6 (Jul). [Reprint requests to Dr. D. R. Johns, Department of Neurology, Johns Hopkins Hospital, 600 North Wolfe St, Meyer 6-119, Baltimore, MD 21287-7619.] Clinical data from 12 Leber's patients from 7 pedigrees with the 15257 mutation were compared to previously published clinical features of Leber's from 11778 and 3460 mutations. Patients with the 15257 mutation were more likely to experience significant recovery of vision. If an associated mutation at np 15812 was present, however, the patient with 15257 mutation was less likely to recover vision. The authors note that "this is the first clinical evidence to support the concept of multiple simultaneous mtDNA mutations producing additive deleterious effects in patients with Leber's." Lyn A. Sedwick, M.D. J Clin Nruro-ophlhalmol, Vol. 13, No.4, 1993 Optic Nerve Decompression Improves Hemodynamic Parameters in Papilledema. MiUra RA, Sergott RC, Flaharty PM, Lieb WE, Savino PI, Bosley TM, Hedges TR Jr. Ophthalmology 1993;100:987-97 (Iul). [Reprint requests to Dr. R. C. Sergott, Neuro-Ophthalmology Service, 900 Walnut St, Philadelphia, PA 19107.] Color Doppler studies were performed on 24 eyes pre- and postoperatively from optic nerve sheath decompression for visual loss in pseudotumor cerebri. All of the 13 eyes with improved visual function postoperatively had improved color Doppler imaging parameters for the short posterior ciliary arteries. None of the eyes that remained stable or worsened had improved color Doppler. The authors suggest that some visual loss in chronic papilledema may be from ischemia, which may be reversed by optic nerve sheath decompression. Lyn A. Sedwick, M.D. |
