Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle and mobility- an exploratory pilot study

Update item information
Publication Type Journal Article
School or College College of Health
Department Physical Therapy
Creator Dibble, Leland E.
Other Author LaStayo, Paul C.; Marcus, Robin L.; Smith, Sheldon B.; Beck, Susan L.
Title Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle and mobility- an exploratory pilot study
Date 2011
Description Background: Resistance exercise programs with high compliance are needed to counter impaired muscle and mobility in older cancer survivors. To date outcomes have focused on older prostate cancer survivors, though more heterogeneous groups of older survivors are in-need. The purpose of this exploratory pilot study is to examine whether resistance exercise via negative eccentrically-induced work (RENEW) improves muscle and mobility in a diverse sample of older cancer survivors. Methods: A total of 40 individuals (25 female, 15 male) with a mean age of 74 (? 6) years who have survived (8.4 ? 8 years) since their cancer diagnosis (breast, prostate, colorectal and lymphoma) were assigned to a RENEW group or a non-exercise Usual-care group. RENEW was performed for 12 weeks and measures of muscle size, strength, power and mobility were made pre and post training. Results: RENEW induced increases in quadriceps lean tissue average cross sectional area (Pre: 43.2 ? 10.8 cm2; Post: 44.9 ? 10.9 cm2), knee extension peak strength (Pre: 248.3 ? 10.8 N; Post: 275.4 ? 10.9 N), leg extension muscle power (Pre: 198.2 ? 74.7 W; Post 255.5 ? 87.3 W), six minute walk distance (Pre: 417.2 ? 127.1 m; Post 466.9 ? 125.1 m) and a decrease on the time to safely descend stairs (Pre: 6.8 ? 4.5 s; Post 5.4 ? 2.5 s). A significant (P < 0.05) group x time interaction was noted for the muscle size and mobility improvements. Conclusions: This exploration of RENEW in a heterogeneous cohort of older cancer survivors demonstrates increases in muscle size, strength and power along with improved mobility. The efficacy of a high-force, low perceived exertion exercise suggests RENEW may be suited to older individuals who are survivors of cancer.
Type Text
Publisher BioMed Central
Volume 11
Issue 5
First Page 2
Last Page 10
DOI 10.1186/1471-2318-11-5
Language eng
Bibliographic Citation LaStayo, P. C., Marcus, R. L., Dibble, L. E., Smith, S. B., & Beck, S. L. (2011). Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle and mobility- an exploratory pilot study. BMC Geriatrics, 11(5), 2-10.
Rights Management © [LaStayo, P. C., Marcus, R. L., Dibble, L. E., Smith, S., & Beck, S. L.]. Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/: Doi:10.1186/1471-2318-11-5
Format Medium application/pdf
Format Extent 314,685 bytes
Identifier ir-main,16500
ARK ark:/87278/s61v5z9z
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 704357
Reference URL https://collections.lib.utah.edu/ark:/87278/s61v5z9z