201 - 225 of 1,138
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CreatorTitleDescriptionSubjectDate
201 Gardner, Reed M.Data Gathering, Analysis, and Display in Critical Care MedicineBiomedical Informatics1985
202 Gardner, Reed M.Computer Charting: An Evaluation of a Respiratory Care Computer SystemBiomedical Informatics1985
203 Thomas, Kirk R.; Capecchi, Mario R.Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian. cell nucleiWe have examined the mechanism of homologous recombination between plasmid molecules coinjected into cultured mammalian cells. Cell lines containing recombinant DNA molecules were obtained by selecting for the reconstruction of a functional Neor gene from two plasmids that bear different amber mutat...Animals; Cells, Cultured; DNA Restriction Enzymes; Kinetics1985-01
204 Thomas, Kirk R.; Capecchi, Mario R.Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei.Heteroduplexes were prepared from two plasmids, pRH4-14/TK and pRH5-8/TK, containing different amber mutations in the neomycin resistance gene (Neor). The Neor gene was engineered to be expressed in both bacterial and mammalian cells. A functional Neor gene conferred kanamycin resistance to bacteria...Cell Nucleus; Cells, Cultured; Microinjections1985-01
205 Mitchell, Joyce A.A medical microcomputer database management systemThe Patient Data Handler (PDH) is a general purpose, interactive, relational database management system (DBMS) which was created to store and retrieve the patient records stemming from a research project centering upon the genetic causes and diagnosis of concomitant deafness and blindness [1, 5]. Th...1985-01-01
206 Blumenthal, Donald K.Identification of the calmodulin-binding domain of skeletal muscle myosin lightIn the course of determining the primary structure of rabbit skeletal muscle myosin light chain kinase (MLCK; ATP:protein phosphotransferase, EC 2.7.1.37) a peptide fragment was obtained that appears to represent the calmodulin-binding domain of this enzyme. Low concentrations of the peptide inhibit...Peptides; Enzymes; Protein sequence1985-05
207 Capecchi, Mario R.Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice.A porcine class I major histocompatibility complex (SLA) gene has been introduced into the genome of a C57BL/10 mouse. This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were...Genetic Engineering; Graft Rejection; Mice, Inbred C57BL1985-05-03
208 Blumenthal, Donald K.Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity.Calmodulin-dependent protein phosphatase purified from bovine cardiac muscle catalyzed the rapid dephosphorylation of Ser-95 of bovine cardiac cAMP-dependent protein kinase regulatory subunit (RII). The kinetic constants determined for the reaction (Km = 20 microM; Vmax = 2 mumol min-1 mg-1) are com...Metabolism; High Pressure Liquid; Enzymology1985-06-25
209 Poulter, Charles Dale; Davis, Darrell R.15N labeled e. coli tRNAMet, tRNAGlu, tRNATyr, and tRNAPhe. Double resonance and two dimensional NMR of H-N1 units in pseudouridineThe N1 imino units in Escherichia coli tRNAfMet, tRNAGlu, tRNAPhe, and tRNATyr were studied by 1H-15N NMR using three different techniques to suppress signals of protons not attached to 15N. Two of the procedures, Fourier internuclear difference spectroscopy and two-dimensional forbidden echo spectr...Escherichia coli; Magnetic resonance spectroscopy; Nucleic acid conformation1985-08-15
210 Poulter, Charles Dale; Davis, Darrell R.15N-labeled Escherichia coli tRNAfMet, tRNAGlu, tRNATyr, and tRNAPhe. Double resonance and two-dimensional NMR of N1-labeled pseudouridine.The N1 imino units in Escherichia coli tRNAfMet, tRNAGlu, tRNAPhe, and tRNATyr were studied by 1H-15N NMR using three different techniques to suppress signals of protons not attached to 15N. Two of the procedures, Fourier internuclear difference spectroscopy and two-dimensional forbidden echo spectr...Escherichia coli; Magnetic resonance spectroscopy; Nitrogen; Nucleic acid conformation1985-08-15
211 Francis, LeslieRecent developments in genetic diagnosis: some ethical and legal implicationsThis essay outlines some of the ethical complexities genetic technology poses in two areas of decision-making: when to perform genetic testing and what to do with the information gained from genetic testing.Genetic Technology; Genetic Testing; Ethics1986
212 Warner, Homer R.A Computer-Directed Patient History: Functional Overview and Initial ExperienceBiomedical Informatics1986
213 Warner, Homer R.Development of a Prototype IAIMS at the University of UtahBiomedical Informatics1986
214 Warner, Homer R.IAIMS Implementation and Administration at the University of UtahBiomedical Informatics1986
215 Warner, Homer R.The HELP System: A System for Clinical Decision-MakingBiomedical Informatics1986
216 Warner, Homer R.HELP: A Computerized Medical Decision Support SystemBiomedical Informatics1986
217 Caserta, Michael; Lund, Dale A.Impact of bereavement on the self-conceptions of older surviving spousesThe purpose of this longitudinal study was to assess the extent to which the social anchorage dimension of the self-concept is impacted by the death of a spouse among a sample of older surviving spouses. Social anchorage was measured by the Twenty Statements Test (TST) in mailed questionnaires and ...Social anchorage; Self-concept1986
218 Baehr, WolfgangLight-dependent changes in G-protein binding to ROS membranes in intact Bufo retinasLight-dependent changes in the binding of G-protein were analyzed in outer segment disk membranes obtained from photoreceptors of the toad (Bufo marinus) retina. Isolated, intact retinas, incubated in oxygenated Ringer's solution at 23 +/- 1 degree C, were subjected to various conditions of illumina...Centrifugation, Density Gradient; Membranes; Adaptation, Physiological1986
219 Gardner, Reed M.Selection and Standardization of Respiratory Monitoring EquipmentBiomedical Informatics1986
220 Gardner, Reed M.The Medical Devices Act and Mandatory Standard Standards Promulgation: What Are the Implications for Respiratory Care? (Editorial)Biomedical Informatics1986
221 Gardner, Reed M.Data Gathering Analysis and Display in Critical Care MedicineBiomedical Informatics1986
222 Poulter, Charles Dale; Davis, Darrell R.15N-labeled tRNA. Identification of dihydrouridine in Escherichia coli tRNAfMet, tRNALys, and tRNAPhe by 1H-15N two-dimensional NMR.The N3 imino units of dihydrouridine were identified in samples of 15N-labeled Escherichia coli tRNAfMet, tRNALys, and tRNAPhe by 1H-15N two-dimensional NMR. The peaks for dihydrouridine had high field 1H (9.7-9.8 ppm) and 15N (147.8-149.5 ppm) chemical shifts. Assignments were made by 1H-15N chemic...Hydrogen Bonding; Magnetic Resonance Spectroscopy; Magnetic Resonance Spectroscopy1986-03-15
223 Capecchi, Mario R.Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene.DNA sequences homologous to the v-abl oncogene were isolated from a Caenorhabditis elegans genomic library by their ability to hybridize with a v-src probe. The DNA sequence of 2465 nucleotides of one clone was determined. This region corresponds to the 5' protein kinase domain of v-abl plus approxi...Amino Acid Sequence; Animals; Base Sequence; Gene Expression Regulation; Transcription, Genetic1986-04
224 Varner, Michael W.Episiotomy: techniques and indications.In current obstetric practice episiotomy is generally taken to refer to an incision of the perineum and vagina to facilitate vaginal delivery. While the most precise definition of this incision is perineotomy, episiotomy is the generally employed terminology and thus is used in this article. The e...Episiotomy; Adverse Effects; Perineotomy1986-06
225 Capecchi, Mario R.Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase.We have examined the effect of cell cycle position on homologous recombination between plasmid molecules coinjected into synchronized rat fibroblasts. Recombination activity was found to be low in G1 and to rise 10- to 15-fold, peaking in early to mid-S phase.Cell Line; Kinetics; Plasmids1986-06
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