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Creator | Title | Description | Subject | Date |
201 |
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Gardner, Reed M. | Data Gathering, Analysis, and Display in Critical Care Medicine | Biomedical Informatics | | 1985 |
202 |
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Caserta, Michael; Lund, Dale A. | Identifying elderly with coping difficulties after two years of bereavement | This study answers three research questions. First, what proportion of the elderly are experiencing major coping difficulties after two years of bereavement? Second, what factors in early bereavement distinguish between those with difficulties and the others? Third, what set of factors are the best... | Coping difficulties | 1985 |
203 |
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Gardner, Reed M. | Computer Charting: An Evaluation of a Respiratory Care Computer System | Biomedical Informatics | | 1985 |
204 |
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Thomas, Kirk R.; Capecchi, Mario R. | Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian. cell nuclei | We have examined the mechanism of homologous recombination between plasmid molecules coinjected into cultured mammalian cells. Cell lines containing recombinant DNA molecules were obtained by selecting for the reconstruction of a functional Neor gene from two plasmids that bear different amber mutat... | Animals; Cells, Cultured; DNA Restriction Enzymes; Kinetics | 1985-01 |
205 |
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Thomas, Kirk R.; Capecchi, Mario R. | Efficient correction of mismatched bases in plasmid heteroduplexes injected into cultured mammalian cell nuclei. | Heteroduplexes were prepared from two plasmids, pRH4-14/TK and pRH5-8/TK, containing different amber mutations in the neomycin resistance gene (Neor). The Neor gene was engineered to be expressed in both bacterial and mammalian cells. A functional Neor gene conferred kanamycin resistance to bacteria... | Cell Nucleus; Cells, Cultured; Microinjections | 1985-01 |
206 |
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Mitchell, Joyce A. | A medical microcomputer database management system | The Patient Data Handler (PDH) is a general purpose, interactive, relational database management system (DBMS) which was created to store and retrieve the patient records stemming from a research project centering upon the genetic causes and diagnosis of concomitant deafness and blindness [1, 5]. Th... | | 1985-01-01 |
207 |
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Blumenthal, Donald K. | Identification of the calmodulin-binding domain of skeletal muscle myosin light | In the course of determining the primary structure of rabbit skeletal muscle myosin light chain kinase (MLCK; ATP:protein phosphotransferase, EC 2.7.1.37) a peptide fragment was obtained that appears to represent the calmodulin-binding domain of this enzyme. Low concentrations of the peptide inhibit... | Peptides; Enzymes; Protein sequence | 1985-05 |
208 |
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Capecchi, Mario R. | Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. | A porcine class I major histocompatibility complex (SLA) gene has been introduced into the genome of a C57BL/10 mouse. This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were... | Genetic Engineering; Graft Rejection; Mice, Inbred C57BL | 1985-05-03 |
209 |
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Blumenthal, Donald K. | Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity. | Calmodulin-dependent protein phosphatase purified from bovine cardiac muscle catalyzed the rapid dephosphorylation of Ser-95 of bovine cardiac cAMP-dependent protein kinase regulatory subunit (RII). The kinetic constants determined for the reaction (Km = 20 microM; Vmax = 2 mumol min-1 mg-1) are com... | Metabolism; High Pressure Liquid; Enzymology | 1985-06-25 |
210 |
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Gardner, Reed M. | Selection and Standardization of Respiratory Monitoring Equipment | Biomedical Informatics | | 1986 |
211 |
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Warner, Homer R. | A Computer-Directed Patient History: Functional Overview and Initial Experience | Biomedical Informatics | | 1986 |
212 |
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Warner, Homer R. | HELP: A Computerized Medical Decision Support System | Biomedical Informatics | | 1986 |
213 |
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Warner, Homer R. | The HELP System: A System for Clinical Decision-Making | Biomedical Informatics | | 1986 |
214 |
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Warner, Homer R. | Development of a Prototype IAIMS at the University of Utah | Biomedical Informatics | | 1986 |
215 |
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Gardner, Reed M. | The Medical Devices Act and Mandatory Standard Standards Promulgation: What Are the Implications for Respiratory Care? (Editorial) | Biomedical Informatics | | 1986 |
216 |
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Francis, Leslie | Recent developments in genetic diagnosis: some ethical and legal implications | This essay outlines some of the ethical complexities genetic technology poses in two areas of decision-making: when to perform genetic testing and what to do with the information gained from genetic testing. | Genetic Technology; Genetic Testing; Ethics | 1986 |
217 |
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Warner, Homer R. | IAIMS Implementation and Administration at the University of Utah | Biomedical Informatics | | 1986 |
218 |
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Caserta, Michael; Lund, Dale A. | Impact of bereavement on the self-conceptions of older surviving spouses | The purpose of this longitudinal study was to assess the extent to which the social anchorage dimension of the self-concept is impacted by the death of a spouse among a sample of older surviving spouses. Social anchorage was measured by the Twenty Statements Test (TST) in mailed questionnaires and ... | Social anchorage; Self-concept | 1986 |
219 |
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Baehr, Wolfgang | Light-dependent changes in G-protein binding to ROS membranes in intact Bufo retinas | Light-dependent changes in the binding of G-protein were analyzed in outer segment disk membranes obtained from photoreceptors of the toad (Bufo marinus) retina. Isolated, intact retinas, incubated in oxygenated Ringer's solution at 23 +/- 1 degree C, were subjected to various conditions of illumina... | Centrifugation, Density Gradient; Membranes; Adaptation, Physiological | 1986 |
220 |
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Gardner, Reed M. | Data Gathering Analysis and Display in Critical Care Medicine | Biomedical Informatics | | 1986 |
221 |
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Capecchi, Mario R. | Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene. | DNA sequences homologous to the v-abl oncogene were isolated from a Caenorhabditis elegans genomic library by their ability to hybridize with a v-src probe. The DNA sequence of 2465 nucleotides of one clone was determined. This region corresponds to the 5' protein kinase domain of v-abl plus approxi... | Amino Acid Sequence; Animals; Base Sequence; Gene Expression Regulation; Transcription, Genetic | 1986-04 |
222 |
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Varner, Michael W. | Episiotomy: techniques and indications. | In current obstetric practice episiotomy is generally taken to refer to an incision of the perineum and vagina to facilitate vaginal delivery. While the most precise definition of this incision is perineotomy, episiotomy is the generally employed terminology and thus is used in this article. The e... | Episiotomy; Adverse Effects; Perineotomy | 1986-06 |
223 |
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Capecchi, Mario R. | Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase. | We have examined the effect of cell cycle position on homologous recombination between plasmid molecules coinjected into synchronized rat fibroblasts. Recombination activity was found to be low in G1 and to rise 10- to 15-fold, peaking in early to mid-S phase. | Cell Line; Kinetics; Plasmids | 1986-06 |
224 |
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Blumenthal, Donald K. | Characterization of the phosphotyrosyl protein phosphatase activity of calmodulin-dependent protein phosphatase. | Calmodulin-dependent protein phosphatase from bovine brain and heart was assayed for phosphotyrosine and phosphoserine phosphatase activity using several substrates: 1) smooth muscle myosin light chain (LC20) phosphorylated on tyrosine or serine residues, 2) angiotensin I phosphorylated on tyrosine,... | Metabolism; Phosphatase Activity | 1986-07-25 |
225 |
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Thomas, Kirk R.; Capecchi, Mario R. | Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. | Injection of homologous DNA sequences into nuclei of cultured mammalian cells induces mutations in the cognate chromosomal gene. It appears that these mutations result from incorrect repair of a heteroduplex formed between the introduced and the chromosomal sequence. This phenomenon is termed 'heter... | Animals; Cell Line; Drug Resistance, Microbial; Fibroblasts; Mice; Models, Genetic; Neomycin; Plasmids | 1986-11-06 |