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176 Kestle, John R. W.; Townsend, Jeannette J.; Brockmeyer, Douglas LeeJuvenile pilocytic astrocytoma of the brainstem in childrenObject. In reports involving the operative treatment of brainstem tumors, multiple histological types are often grouped together. To determine prognosis after resection, histology-specific data may be helpful. Methods. Twenty-eight patients with juvenile pilocytic astrocytoma (JPA) of the brainste...Juvenile pilocytic astrocytoma; JPA; Brainstem tumors; Resection2004
177 Couldwell, William T.; Viskochil, David H.; Fults, Daniel WebsterMolecular, genetic, and cellular pathogenesis of neurofibromas and surgical implicationsNEUROFIBROMATOSIS 1 (NF1) IS A common autosomal dominant disease characterized by complex and multicellular neurofibroma tumors. Significant advances have been made in the research of the cellular, genetic, and molecular biology of NF1. The NF1 gene was identified by positional cloning. The function...Loss of heterozygosity; Malignant peripheral nerve sheath tumor; Plexiform Neurofibroma; Spinal neurofibroma2006
178 Kestle, John R. W.Death after late failure of third ventriculostomy in childrenLate failure following successful third ventriculostomy for obstructive hydrocephalus is rare, and death caused by failure of a previously successful third ventriculostomy has been reported only once. The authors present three patients who died as a result of increased intracranial pressure (ICP) a...Ventriculostomy; Obstructive hydrocephalus; Late failure; Death2002
179 Kestle, John R. W.; MacDonald, Joel D.; Schmidt, Richard H.Marked reduction of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhageObject. Cerebral vasospasm after subarachnoid hemorrhage (SAH) continues to be a major source of morbidity in patients despite significant clinical and basic science research. Efforts to prevent vasospasm by removing spasmogens from the subarachnoid space have produced mixed results. The authors hyp...Cerebral vasospasm; Lumbar drainage2004
180 Couldwell, William T.; Gillespie, David L.; Jensen, Randy L.Novel model of intracranial meningioma in mice using luciferase-expressing meningioma cellsObject. Meningioma research has been hindered by the inability to sequentially measure intracranial tumor growth in a cost-effective, efficient manner. Recently, the luciferase gene has been transfected into cancer lines to obtain cells that express the luciferase enzyme, which oxidizes luciferin in...2008-01-01
181 Couldwell, William T.Assessment of long-term remission of acromegaly following surgeryObject. The criteria for remission of acromegaly following transsphenoidal adenoma resection are in evolution. In the present study the authors evaluate the utility of predicting long-term remission by reference to a single fasting growth hormone (GH) level on the 1st postoperative day. Methods. A ...Acromegaly; Pituitary adenoma; Transsphenoidal surgery; Growth hormone; Insulin-like growth factor I2003-01-01
182 Dailey, Andrew T.; Brodke, Darrel S.Cervical end of an occipitocervical fusion: a biomechanical evaluation of 3 constructsObject. Stabilization with rigid screw/rod fixation is the treatment of choice for craniocervical disorders requiring operative stabilization. The authors compare the relative immediate stiffness for occipital plate fixation in concordance with transarticular screw fixation (TASF), C-1 lateral mass...Harms technique; Occipitocervical fusion; Transarticular screw; Translaminar screw; Craniocervical instability2008
183 Kestle, John R. W.; Brockmeyer, Douglas LeeOutcomes after decompressive craniectomy for severe traumatic brain injury in childrenObject. Severe traumatic brain injury (TBI) is often accompanied by early death due to transtentorial herniation. Decompressive craniectomy, performed alone or in conjunction with evacuation of the mass lesion, can reduce the incidence of raised intracranial pressure (ICP). In this paper the authors...Traumatic brain injury; Decompressive craniectomy; Pediatric neurosurgery2006
184 Digre, Kathleen B.; Couldwell, William T.; Amini, AminPhotophobia in a blind patient: An alternate visual pathway. Case report.Photophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from multi...Photophobia, Blindness, Signaling Pathway, Pretectal Nuclei, Trigeminal Pathway2006-12-14
185 Couldwell, William T.; Jensen, Randy L.; Gillespie, David L.Celecoxib inhibits meningioma tumor growth in a mouse xenograft modelBackground: Treatments for recurrent meningiomas are limited. We previously demonstrated universal expression of COX-2 in meningiomas and dose-dependent growth inhibition in vitro with celecoxib, a COX-2 inhibitor. We therefore tested the effects of celecoxib on meningioma growth in a mouse xenograf...Meningioma; Cyclooxygenase-2; COX-2; Celecoxib2007
186 Couldwell, William T.Management of cysticercosis cerebriInfestation of the central nervous system (CNS) with the parasitic larval form of the cestode Taenia solium, Cysticercosis Cerebri represents an endemic problem in much of the underdeveloped world. In such areas, up to 4% of the population maybe affected by neurocysticercosis, and it accounts for u...Taenia solium; Cysticercosis Cerebri; Parenchymal cyst; Basilar cisternal cyst; Intraventricular cyst1989
187 Schmidt, Meic H.Syndrome of inappropriate secretion of antidiuretic hormone and hyponatremia after spinal surgeryHyponatremia caused by an inappropriately high level of antidiuretic hormone secretion after spinal surgery is an uncommon and self-limiting phenomenon that resolves within 2 or 3 weeks. During the early postoperative period, the patient's urine output and serum level of sodium should be monitored ...Syndrome of inappropriate antidiuretic hormone secretion; SIADH; Hyponatremia; Spinal surger2004
188 Couldwell, William T.; Nelson, Don HarryNelson syndrome: historical perspectives and current conceptsThe appearance of an adrenocorticotropic hormone (ACTH)-producing tumor after bilateral adrenalectomy for Cushing disease was first described by Nelson in 1958. The syndrome that now bears his name was characterized by hyperpigmentation, a sellar mass, and increased plasma ACTH levels. The treatment...2007-01-01
189 Kestle, John R. W.; Brockmeyer, Douglas LeeCranial base strategies for resection of craniopharyngioma in childrenThe optimal treatment of craniopharyngioma in children remains a challenge. The use of complete excision to minimize recurrence continues to be controversial because of the risk of postoperative morbidity and death. Advances in skull base approaches, modern microsurgical techniques, neuroimaging, an...Craniopharyngioma; Surgical approach; Skull base surgery2005
190 Couldwell, William T.Recurrent infrasellar clival craniopharyngiomaThe patient is a 44-year-old man who underwent resection of a posterior nasopharynx tumor 12 years earlier via left lateral rhinotomy approach. The final pathological analysis indicated the tumor was a craniopharyngioma, and the patient subsequently underwent focal radiation. The patient returned t...Ectopic Craniopharyngioma; Recurrence; Infrasellar; Clivus2007
191 Couldwell, William T.Comment on Wong, H. T., et al.: Comparative impact of video consultation on emergency neurosurgical referralsThe Author's explored the facility and accuracy of telephone, teleradiology, or video consultation between a large general hospital and their tertiary neurosurgical center. Although there was increased diagnostic accuracy with video consultation or teleradiology, they note that consultation via vid...Teleradiology; Video consultation; Neurosurgical referrals2006
192 Couldwell, William T.Transfacet pedicle-sparing approach for thoracic disc removal: cadaveric morphometric analysis and preliminary clinical experienceA number of operative techniques have been described for the treatment of herniated thoracic discs. The transfacet pedicle-sparing approach allows for complete disc removal with limited spinal column disruption and soft-tissue dissection. Fifteen cadaveric spinal columns were used for evaluation of...Thoracic spine; Herniated thoracic discs; Intervertebral disc herniation; Discectomy; Pedicle; Radiculopathy; Myelopathy1998
193 Couldwell, William T.Communication between malignant glioma cells and vascular endothelial cells through gap junctionsObject. Extensive invasion and angiogenesis are hallmark features of malignant gliomas. Communication between malignant glioma cells and surrounding astrocytes occurs, resulting in transformation of the astrocytic phenotype. In the present study, the authors examined whether malignant glioma cells a...2003-01-01
194 Couldwell, William T.; MacDonald, Joel D.Surgical strategies for recurrent craniofacial meningiomasRecurrent cranial base meningiomas are among the most difficult tumors to treat surgically. Although they are histologically benign, these tumors often invade through the cranial base into the infratemporal and pterygopalatine fossae. We reviewed our experience with these tumors to describe the nat...Craniofacial meningiomas; Recurrence; Cranial base tumor; Neoplasm2006
195 Couldwell, William T.Development of neurosurgery in Southern California and the Los Angeles County/University of Southern California Medical CenterThe Los Angeles County General Hospital has played an integral role in the development of medicine and neurosurgery in Southern California. From its fledgling beginnings, the University of Southern California School of Medicine has been closely affiliated with the hospital, providing the predomina...Historical vignette; Los Angeles County General Hospital; University of Southern California School of Medicine; Neurosurgical history1993
196 Couldwell, William T.Ganglion cyst of the temporomandibular joint with intracranial extension in a patient presenting with seventh cranial nerve palsyGanglion cysts arising from the temporomandibular joint are rare entities that often present with swelling and minimal to no pain in the preauricular region. To the Author's? knowledge, a temporomandibular joint ganglion cyst occurring with acute facial nerve palsy and intracranial extension has ne...2012
197 Couldwell, William T.Metastatic melanoma to the pituitary glandMetastasis to the pituitary gland is unusual, and occurs most often in patients with carcinomas of the breast or lung. Despite its propensity for spread to the brain, metastatic melanoma has rarely been described within the sella. Methods: We report two cases of malignant melanoma pathologically co...2007
198 Schmidt, Meic H.Frameless stereotactic image-guided C1-C2 transarticular screw fixation for atlantoaxial instability: review of 20 patientsAtlantoaxial instability can result from trauma, rheumatoid arthritis, congenital malformation, or tumor invasion. The goal of treatment is stabilization of the C1-C2 complex to prevent neurologic and neurovascular compromise. First described in 1987 by Magerl and Seemann, C1-C2 transarticular screw...Transarticular screws; Atlantoaxial instability; Frameless stereotaxy; Cervical spine; Surgical navigation; Trajectory planning2005
199 Schmidt, Meic H.; Kestle, John R. W.Treatment of metastatic spinal epidural disease: a review of the literatureObject. Spinal cord compression is one of the most dreaded complications of metastatic cancer. It can lead to a number of sequelae, including pain, spinal instability, neurological deficits, and a reduction in the patient's quality of life. Except in selected circumstances, treatment is palliative. ...Spinal cord compression; Metastasis; Radiation therapy; Stereotactic radiosurgery2003
200 Kestle, John R. W.Relationship of intraoperative electrophysiological criteria to outcome after selective functional posterior rhizotomyAt British Columbia's Children's Hospital, the criteria used in selective functional posterior rhizotomy (SFPR) evolved in three distinct phases. In Phase 1 the electrophysiological criteria for abnormality included a low threshold to a single stimulation, a sustained response to 50-Hz stimulation, ...Selective posterior rhizotomy; Electrophysiological criteria; Intraoperative electrical stimulation1995
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