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Creator | Title | Description | Subject | Date |
| 176 |
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Blair, David F. | Metal centers of cytochrome c oxidase: structures and interactions | Studies directed toward the elucidation of the structures of the metal centers in cytochrome c oxidase are reviewed. Progress towards an understanding of the interactions between these centers and their spatial distributions within the protein will also be presented. Our studies are based primarily... | | 1983 |
| 177 |
 |
Hansen, Mark S.; Coffin, Cheryl M.; Capecchi, Mario R. | Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. | To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do... | Neuroprogenitor; Embryogenesis | 2004-11-01 |
| 178 |
 |
Olivera, Baldomero M.; Bulaj, Grzegorz | Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors | We report the discovery and characterization of three conantokin peptides from the venom of Conus parius. Each peptide (conantokin-Pr1, -Pr2, and -Pr3) contains 19 amino acids with three γ-carboxyglutamate (Gla) residues, a post-translationally modified amino acid characteristic of conantokins. The... | Conotoxins; Conantokins; Conus parius; Antagonists; n-methyl-D-aspartate receptors | 2007 |
| 179 |
 |
Capecchi, Mario R. | Male fertility is dependent on dipeptidase activity of testis ACE. | Testis angiotensin-converting enzyme (ACE) is an isozyme exclusively expressed by developing sperm. This protein has only a single catalytic domain containing the HEXXH consensus-site motif typical of zinc metallopeptidases. The exact role of testis ACE is unknown, but male mice lacking the protein ... | Amino Acid Motifs; Blotting, Western; Catalytic Domain; Comparative Study; Isoenzymes; Protein Structure, Tertiary | 2005-11-11 |
| 180 |
 |
Coley, Phyllis D. | Guía de los arboles comunes del Parque Nacional Soberanía, Panamá | Esta es una guía con dibujos para las cincuenta especies de árboles más comunes del bosque tropical en los alrededores del Parque Soberanía, Panamá. También se incluyen siete especies de hierbas y cuatro herbáceas grandes que sobresalen en el sotobosque (bosque bajo). Aunque en el área del p... | Arboles; Arbustos | 1984 |
| 181 |
 |
Goller, Franz | Bilateral syringeal contributions to song in the zebra finch | Although central control of song production has been investigated extensively in the zebra finch (Taeniopygia guttata), much less is known about peripheral vocal motor dynamics during song. | Electromyographic activity; Sound souces; Unilateral | 2004 |
| 182 |
 |
Capecchi, Mario R. | Choose your target. | The technology of modifying endogenous genes has recently been extended from mice to Drosophila and sheep. Concurrently, genomic sequencing is uncovering thousands of previously uncharacterized genes. Armed with today's technologies, what are our best options for delineating the functions of these n... | Animals; Mice; Sheep | 2000-09-13 |
| 183 |
 |
Beckerle, Mary C. | Molecular dissection of zyxin function reveals its involvement in cell motility | Spatially controlled actin filament assembly is critical for numerous processes, including the vectorial cell migration required for wound healing, cell-mediated immunity, and embryogenesis. One protein implicated in the regulation of actin assembly is zyxin, a protein concentrated at sites where t... | Zyxin; Actinin; Ena/VASP | 1999 |
| 184 |
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Adler, Frederick R.; Jackson, Brian Richard; Carroll, Karen C.; Samore, Matthew H. | Use of strain typing data to estimate bacterial transmission rates in healthcare settings | OBJECTIVE: To create an affordable and accurate method for continuously monitoring bacterial transmission rates in healthcare settings. DESIGN: We present a discrete simulation model that relies on the relationship between in-hospital transmission rates and strain diversity. We also present a proof... | Strain typing; Infection control; Transmission model | 2005 |
| 185 |
 |
Davidson, Diane W. | Pruning of host plant neighbors by ants: an experimental approach | Some ants of myrmecophytic plants either obligately or facultatively prune vegetation surrounding their host trees. Pruning behavior occurs at higher frequency in ants with sting defenses than in those with chemical defenses, which may generally convey an advantage in aggressive encounters between a... | Allelopathy; Allomerus demararae; Ant-plant interactions; Ants; Cordia nodosa; Crematogaster; Mutualism; Peru; Plant-animal interaction; Pseudomyrmex; Triplaris americana | 1988 |
| 186 |
 |
Jorgensen, Erik | Neural plasticity | Neural plasticity refers to functional changes in the nervous system and therefore encompasses a range of phenomena from changes at synapses observed on a microscopic scale to changes in behavior observed in the whole animal. These diverse phenomena are related since changes in synapses are believ... | Synapses; Nervous System; Development | 1997 |
| 187 |
 |
Jorgensen, Erik | UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles | The unc-11 gene of Caenorhabditis elegans encodes multiple isoforms of a protein homologous to the mammalian brain-specific clathrin-adaptor protein AP180. The UNC-11 protein is expressed at high levels in the nervous system and at lower levels in other tissues. In neurons, UNC-11 is enriched at pr... | Caenorhabditis elegans; Synaptic vesicles; unc-11; Synaptobrevin; Endocytosis | 1999 |
| 188 |
 |
Capecchi, Mario R. | Gene targeting: an historical perspective | Our entry into what was going to become the field of gene targeting began in 1977. I was experimenting with the use of extremely small glass needles to inject DNA directly into the nuclei of living cells. The needles were controlled by hydraulically driven micro-manipulators and were directed into n... | Gene targeting -- History; Homologous recombination | 1998 |
| 189 |
 |
Bohs, Lynn A. | Phylogenetic relationships in Solanum (Solanaceae) based on ndhF sequences | A phylogenetic analysis was conducted using sequence data from the chloroplast gene ndhF. Sequences were obtained from 25 species of Solanaceae, including 18 species of Solanum representing five of the seven conventionally recognized subgenera. | Solanum; ndhF | 1997 |
| 190 |
 |
Olivera, Baldomero M. | ?O-Conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2 | The ?O-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus, belonging to the O-superfamily of conotoxins with three disulfide bridges. They have attracted attention because they are inhibitors of tetrodotoxin-insensitive voltage-gated sodium channels (NaV1.8) and could therefore ... | | 2007 |
| 191 |
 |
Thomas, Kirk R.; Capecchi, Mario R. | Maintenance of functional equivalence during paralogous Hox gene evolution. | Biological diversity is driven mainly by gene duplication followed by mutation and selection. This divergence in either regulatory or protein-coding sequences can result in quite different biological functions for even closely related genes. This concept is exemplified by the mammalian Hox gene comp... | Alleles; Animals; Cervical Vertebrae; Embryo; Genetic Complementation Test; Homeodomain Proteins; Homozygote; Mice | 2000-02-10 |
| 192 |
 |
Bohs, Lynn A. | Phylogeny and biogeography of the Canarian Solanum vespertilio and S. lidii (Solanaceae) | The endemic and rare Solanum vespertilio and S. lidii from the Canary Islands are notable in being andromonoecious, self compatible, highly heterandrous (with short >reward= anthers and one very long >pollination= anther), and bearing strongly zygomorphic corollas. Solanum vespertilio flowers are a... | Solanum vespertilio; Solanum lidii; Leptostemonum; tnT-F region; granule-bound starch synthase gene; GBSSI; Andromonoecy; Hererandry; Enantiostyly | 2006 |
| 193 |
 |
Capecchi, Mario R. | Personal view of gene targeting | Gene targeting provides the means for creating strains of mice with mutations in virtually any gene.1 First, the desired mutation is introduced into a cloned copy of the chosen gene by standard recombinant DNA technology. The mutation is then transferred to the genome of a pluripotent mouse embryo-d... | | 1995 |
| 194 |
 |
Capecchi, Mario R. | Characterization of three proteins involved in polypeptide chain termination. | At each stage of elongation, the growing polypeptide chain is bound to the ribosome-messenger RNA complex through the transfer RNA of the most recently incorporated amino acid residue. When the chain is complete, the last polypeptide-transfer RNA (tuna) ester linkage is cleaved, releasing the chain ... | Anti-Bacterial Agents; Phenylalanine; Stimulation, Chemical | 1969 |
| 195 |
 |
Thomas, Kirk R.; Capecchi, Mario R. | High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. | Mutations were targeted to the Hprt locus in murine embryonic stem cells by using sequence replacement vectors. When the vector was designed such that the mutated sequences were flanked on both sides by several kilobases of DNA homologous to the target locus, replacement of chromosomal sequences wit... | Drug Resistance; Gene Rearrangement; Gentamicins | 1992-07 |
| 196 |
 |
Coley, Phyllis D. | Benefits and costs of defense in a neotropical shrub | Benefits and costs are central to optimality theories of plant defense. Benefit is the gain in fitness to reducing herbivory and cost is the loss in fitness to committing resources to defense. We evaluate the benefits and costs of defense in a neotropical shrub, Psychotria horizontalis. Plants were ... | Cost of defense; Growth-defense trade-off; Exclosures; Field experiment; Herbivory; Panama; Psychotria horizontalis; Rubiaceae; Tannins; Toughness; Tropics | 1995 |
| 197 |
 |
Beckerle, Mary C. | Kindler syndrome protein is regulated by Transforming Growth Factor-β and involved in integrin-mediated adhesion | Transforming growth factor-β1 (TGF-β1) contributes to tumor invasion and cancer progression by increasing the motility of tumor cells. To identify genes involved in TGF-β-mediated cell migration, the transcriptional profiles of human mammary epithelial cells (HMEC) treated with TGF-β were compar... | Kindler syndrome; Kindlerin; Talin; Focal adhesions; FERM domain | 2004 |
| 198 |
 |
Capecchi, Mario R. | Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II | Recently, the concept of local renin-angiotensin systems (RAS) capable of generating angiotensin II apart from the circulation has received considerable attention. To investigate this, we generated ACE 1/3 mice in which one allele of ACE is null and the second allele was engineered to express ACE o... | | 2003 |
| 199 |
 |
Capecchi, Mario R. | Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. | A porcine class I major histocompatibility complex (SLA) gene has been introduced into the genome of a C57BL/10 mouse. This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were... | Genetic Engineering; Graft Rejection; Mice, Inbred C57BL | 1985-05-03 |
| 200 |
 |
Coley, Phyllis D. | Coibanoles, a new class of meroterpeniods produced by pycnoporus sanguineus | Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites ?coibanoles A?C? in reference to... | | 2012 |
