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Creator | Title | Description | Subject | Date |
| 151 |
 | Baehr, Wolfgang; Thulin, Craig | Immunolocalization and divergent roles of phosducin and phosducin-like protein in the retina | PURPOSE: These investigations were undertaken to compare and contrast the roles of phosducin and phosducin-like protein in the retina. METHODS: Phosducin and phosducin-like protein were compared in an in vitro assay measuring their inhibition of transducin binding to light-activated rhodopsin. The t... | Antibody Specificity; Protein Binding; Rod Outer Segments | 1999 |
| 152 |
 | Baehr, Wolfgang | Metabolism and transactivation activity of 13,14-dihydroretinoic acid | The metabolism of vitamin A is a highly regulated process that generates essential mediators involved in the development, cellular differentiation, immunity, and vision of vertebrates. Retinol saturase converts all-trans-retinol to all-trans-13,14-dihydroretinol (Moise, A. R., Kuksa, V., Imanishi, Y... | Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Retinoid X Receptors | 2005 |
| 153 |
 | Digre, Kathleen B.; Schmidt, Richard H.; Osborne, Anne G.; Patel, Bhupendra C.; Pratt, David; Rietz, Lisa A. | Compressive optic neuropathy caused by renal osteodystrophy. Case report. | Compressive optic neuropathy with acute or chronic vision loss has been associated with various skull base tumors, aneurysms, Graves disease, trauma, and, less commonly, fibrous dysplasia and osteopetrosis. The Author's present a case of acute visual deterioration in a 25-year-old woman who had mass... | Optic Neuropathy; Optic Nerve Decompression; Renal Osteodystrophy | 2001-10 |
| 154 |
 | Baehr, Wolfgang | Role of photoreceptor-specific retinol dehyrogenase (prRDH) in the retinoid cycle in vivo | The retinoid cycle is a recycling system that replenishes the 11-cis-retinal chromophore of rhodopsin and cone pigments. Photoreceptor-specific retinol dehydrogenase (prRDH) catalyzes reduction of all-trans-retinal to all-trans-retinol and is thought to be a key enzyme in the retinoid cycle. We d... | Rhodopsin, Photoreceptors; prRDH (RDH8); All-trans-RDH; A2E; Retinoid cycle; Dark adaptation | 2005 |
| 155 |
 | Bernstein, Paul S. | Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal models | PURPOSE: To determine the stereochemistry of carotenoids in human ocular tissues in comparison with plasma and liver and to elucidate the possible transformations of dietary (3R,3'R,6'R)-lutein and (3R,3'R)-zeaxanthin in the eye. Similarly, to characterize the carotenoid profiles in the eye tissues,... | Chromatography, High Pressure Liquid; Stereoisomerism; Xanthophylls | 2002 |
| 156 |
 | Normann, Richard A.; Clark, Gregory A.; McDonnall, Daniel | Selective motor unit recruitment via intrafascicular multielectrode stimulation | Recruitment of force via independent asynchronous firing of large numbers of motor units produces the grace and endurance of physiological motion. We have investigated the possibility of reproducing this physiological recruitment strategy by determining the selectivity of access to large numbers of ... | Funtional Neuromuscular Stimulation; Microelectrode Array; Neuroprosthesis; Intrafascicular Multielectrode Stimulation; Cats | 2004 |
| 157 |
 | Baehr, Wolfgang | Characterization of the chicken GCAP gene array and analyses of GCAP1, GCAP2, and GC1 gene expression in normal and rd chicken pineal | PURPOSE: This study had three objectives: (1) to characterize the structures of the chicken GCAP1 and GCAP2 genes; (2) to determine if GCAP1, GCAP2, and GC1 genes are expressed in chicken pineal gland; (3) if GC1 is expressed in chicken pineal, to determine if the GC1 null mutation carried by the re... | Molecular Sequence Data; Promoter Regions (Genetics); Retinal Degeneration | 1999 |
| 158 |
 | Angelucci, Alessandra | Multiple components of surround modulation in primary visual cortex: Multiple neural circuits with multiple functions? | The responses of neurons in primary visual cortex (V1) to stimulation of their receptive field (RF) are modulated by stimuli in the RF surround. This modulation is suppressive when the stimuli in the RF and surround are of similar orientation, but less suppressive or facilitatory when they are cross... | | 2014-01-01 |
| 159 |
 | Baehr, Wolfgang | Characterization of bovine rod outer segment G-protein | A simple modified procedure is described for isolating and purifying peripherally bound membrane proteins from bovine rod outer segment disks. The methods yield milligram quantities of G-protein and cGMP phosphodiesterase which are suitable for reconstitution with membranes containing visual pi... | Heterotrimeric GTP-Binding Proteins; Macromolecular Substances; Rhodopsin | 1982 |
| 160 |
 | Baehr, Wolfgang | Annotation and analysis of 10,000 expressed sequence tags from 3 mouse eye cDNA libraries | BACKGROUND: As a biomarker of cellular activities, the transcriptome of a specific tissue or cell type during development and disease is of great biomedical interest. We have generated and analyzed 10,000 expressed sequence tags (ESTs) from three mouse eye tissue cDNA libraries: embryonic day 15.5 (... | Cluster Analysis; DNA, Complementary; Gene Expression Profiling | 2003 |
| 161 |
 | Jones, Bryan W. | Molecular phenotyping of retinal ganglion cells | Classifying all of the ganglion cells in the mammalian retina has long been a goal of anatomists, physiologists, and cell biologists. The rabbit retinal ganglion cell layer was phenotyped using intrinsic small molecule signals (aspartate, glutamate, glycine, glutamine, GABA, and taurine) and glutama... | Aspartic Acid/metabolism; Image Cytometry/methods | 2002 |
| 162 |
 | Kriesel, John D.; Gooch, Willis M.; Pavia, Andrew T. | Invasive sinonasal disease due to Scopulariopsis candida: case report and review of scopulariopsosis. | Sinonasal infection with fungi of the order Mucorales--termed mucormycosis or zygomycosis--is sometimes seen in immunosuppressed patients, including those with diabetic ketoacidosis and malignancy. We describe a case of invasive sinonasal infection with Scopulariopsis candida (not among the Mucorale... | Granulocyte Colony-Stimulating Factor; Itraconazole; Maxillary Sinus | 1994 |
| 163 |
 | Kriesel, John D.; Spruance, Spotswood L. | Treatment of herpes simplex labialis. | Recurrent herpes simplex labialis is associated with mild morbidity, but remains a significant problem for people with frequent and/or severe recurrences. Both topical and peroral episodic antiviral treatments of recurrences are modestly effective at reducing the duration of signs and symptoms. Rece... | Randomized Controlled Trials; Steroids; Drug Administration Routes | 2002 |
| 164 |
 | Baehr, Wolfgang | Expression and mutagenesis of mouse rod photoreceptor cGMP phosphodiesterase | Using recombinant baculovirus vectors, the three subunits of mouse rod photoreceptor cGMP phosphodiesterase (PDE) (alpha beta gamma 2) have been expressed in insect cells. The recombinant alpha,beta subunits accumulate to 5 mg/liter culture, but most (98%) of the expressed polypeptides are insoluble... | Electrophoresis, Polyacrylamide Gel; Macromolecular Substances; Protein Processing, Post-Translational | 1994 |
| 165 |
 | Baehr, Wolfgang | Human interstitial retinoid-binding protein. Gene structure and primary structure | Interstitial retinoid-binding protein (IRBP) is synthesized and secreted by rod photoreceptor cells into the interphotoreceptor matrix and is known to bind retinoids and fatty acids. We have used cDNA clones encoding human IRBP to isolate a 15-kilobase genomic fragment that encompasses the complete ... | Molecular Sequence Data; Eye Proteins; Retinol-Binding Proteins; Messenger RNA | 1989-05-15 |
| 166 |
 | Baehr, Wolfgang; Rao, Narayanam V. | Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily | The mammalian retina contains at least two guanylyl cyclases (GC1 and GC2) and two guanylyl cyclase-activating proteins (GCAP1 and GCAP2). Here we present evidence of the presence of a new photoreceptor-specific GCAP, termed GCAP3, which is closely related to GCAP1. The sequence similarity of GCAP3 ... | Amino Acid Sequence; Cloning, Molecular; Gene Expression Regulation | 1999 |
| 167 |
 | Levine, Edward M. | Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro. | The hedgehog gene family encodes secreted proteins important in many developmental patterning events in both vertebrates and invertebrates. In the Drosophila eye disk, hedgehog controls the progression of photoreceptor differentiation in the morphogenetic furrow. To investigate whether hedgehog prot... | Sonic hedgehog; Indian hedgehog; Desert hedgehog; Retina; Mitogenesis; Differentiation; Rod Photoreceptor | 1997-08-15 |
| 168 |
 | Frederick, Jeanne M. | Neurotransmitter properties of the newborn human retina. | Human retinal tissue from a newborn was examined autoradiographically for the presence of highaffinity uptake and localization of the following putative neurotransmitters: dopamine, glycine, GAB A, aspartate, and glutamate. In addition, the dopamine content of this newborn retina was measured by ... | Newborn; Human Retina; Neurotransmitter Properties; Photoreceptors | 1983 |
| 169 |
 | Normann, Richard A. | Effects of GABA and related drugs on horizontal cells in the isolated turtle retina | The role of GABA in the outer plexiform layer of the turtle retina has been examined by intracellular recordings from L- and C-type horizontal cells in the isolated retina preparation. GABA (1-5 mM) slightly depolarized the L-type horizontal cells, reduced the amplitude of their photoresponses, and ... | Retina; Horizontal Cells; Synapse; Negative Feedback; GABA; Turtle | 1990 |
| 170 |
 | Digre, Kathleen B. | CT and hemifacial spasm. | Forty-six patients with typical hemifacial spasm had CT. Thirty-eight (83%) were abnormal, including two with surgically documented tumors. Thirty-six had a characteristic dolichoectatic vertebrobasilar artery, with the convexity pointing to the side of the spasm in 92% of the scans. This study sugg... | Hemifacial spasms; Tumors; Dolichoectiatic vertebrobasilar artery | 1988-07 |
| 171 |
 | Bernstein, Paul S.; Leppert, Mark F. | Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings | PURPOSE: Single-copy variants of the autosomal recessive Stargardt disease (STGD1) gene ABCR (ABCA4) have been shown to confer enhanced susceptibility to age-related macular degeneration (AMD). To investigate the role of ABCR alleles in AMD further, genotype-phenotype analysis was performed on sibli... | DNA Mutational Analysis; Nuclear Family; Phenotype | 2002 |
| 172 |
 | Bernstein, Paul S. | Identification of lutein and zeaxanthin oxidation products in human and monkey retinas | PURPOSE: To characterize fully all the major and minor carotenoids and their metabolites in human retina and probe for the presence of the oxidative metabolites of lutein and zeaxanthin. METHODS: Carotenoids of a composite of 58 pairs of human retinas and a monkey retina were elucidated by comparing... | Mass Spectrometry; Oxidation-Reduction; Spectrophotometry, Ultraviolet | 1997 |
| 173 |
 | Olson, Randall J.; Spencer, Terrence S.; Mamalis, Nick | Three-year clinical comparison of 3-piece AcrySof and SI-40 silicone intraocular lenses | PURPOSE: To compare the 3-year performance of the 3-piece AcrySof (Alcon) and the SI-40 silicone (Allergan) intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. METHODS: In this retrospective study, patients with no complications and at least a... | Acrylic Resins; Silicone Elastomers; Prosthesis Design; Postoperative Complications; Patient Satisfaction; Cataract | 2002-07 |
| 174 |
 | Baehr, Wolfgang | Receptors for advanced glycation end products as progressive factors in age-related macular degeneration | Advanced glycation end products (AGE) exacerbate disease progression through two general mechanisms: modifying molecules and forming nondegradable aggregates, thus impairing normal cellular/tissue functions, and altering cellular function directly through receptor-mediated activation. In the prese... | Advanced glycation end products; AGE; receptor for AGE-mediated cellular activation; RAGE | 2004 |
| 175 |
 | Bernstein, Paul S.; Gellermann, Werner | Raman detection of macular carotenoid pigments in intact human retina | PURPOSE: To develop and test a novel noninvasive optical technique suitable for the objective measurement of macular carotenoid levels in human retina. METHODS: A resonance Raman scattering apparatus was constructed to measure carotenoid levels in flat-mounted human retinas and eyecups and in experi... | Rana pipiens; Spectrum Analysis, Raman; Xanthophylls | 1998 |
