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151 Cantrell, Rachel Lou-La VonneSynthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization ChemistryAs bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant...2020
152 Randolph, CharlotteSynthesis of VLC-Pufas relating to macular degenerative diseasesVery Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs) are non-dietary fatty acids that are more than 24 carbons long and include more than one double bond. The specific compound we have focused on is 32:6 n-3: a 32-carbon molecule having 6 cis alkenes with the alkenes beginning at the omega 3 carb...2022
153 Domagala, DrueSynthesis of protacs to inhibit toll-like receptorsThe immune system is the body's defense against pathogens. Since it has to be able to withstand the fast-evolving nature of microscopic invaders, the immune system has a variety of mechanisms to recognize and destroy them. One way that pathogens are recognized is through toll-like receptor (TLR) sig...2022
154 Judd, David PaulTelomere proteins of Drosophila melanogaster: HipHop and MSK81DNA molecules encoding two proteins, HipHop and MSK81, were cloned into bacteria so as to make large amounts of these proteins that bind to telomeres of Drosophila (fruit fly) chromosomes. The goal was to determine whether known DNA binding motifs are present in HipHop and MSK81. Understanding how t...Biology2012-05
155 Roestenburg, JessicaTesting the Perceptual Salience of Spectral Content in Zebra Finch SongBirds actively adjust the resonance properties of the upper vocal tract during singing, which results in specific harmonic structures of song elements. To what degree upper vocal tract filtering is relevant for the perceptual salience of song is poorly understood. This research utilizes (1) a biolog...2018
156 Gardner, JennaThe Disparity Between Student Science Writing and Professional Sciencetific WritingThere exists a disparity between student scientific writing and professional scientific writing. The audience, format, and intention of student papers as presented in the science classroom is different from those in the scientific field where the goal is to fully convince an unfamiliar audience and ...2017
157 Curtis, Kaili BreannThe Effect of Inflammatory Components on Influenza a Virulence EvolutionThe methodology for passaging influenza A virus in the mouse model has widely been established. However, traditional infection methods involving the inoculation of lung homogenates fail to account for the possible effects of host-associated factors on measures of virulence and in the virulence evolu...2020
158 Azadpour, ElmeraThe Effect of Inorganic VS Organic Fertilizer on an Urban Lawn in Salt Lake City, UtahWhile lawn management practices have altered the capacity for urban lawns to act as Nitrogen (N) sinks, there have been few studies of the effects of organic vs. inorganic fertilizer additions to urban lawns. We evaluated how foliar and soil N content and isotopic N composition (δ15N) varied as a r...2019
159 Thomas, NathanielThe HIV-protective bystander effect in macrophages is viral glycoprotein dependent and likely conferred via upregulation of ISG IFITM3During an immune response against a specific antigen, often during viral infections, T cells not specific to the antigen can be activated, a phenomenon known as bystander response. The "bystander response" has been studied extensively in T cells, but when examined for macrophages through the lens of...2022
160 Tse, JustinThe Linear Algebra of the Last Passage Percolation ModelWe study the linear algebra of the last passage percolation model. In this model, we want to find the statistics of maximal paths through a randomly weighted grid. Specifically we focus on bases of the set of path lengths made from paths. The maximum path length is a deterministic function of a much...2017
161 Hayashi, SamanthaThe Mechanism of Lysosome Movement During ER StressThe Endoplasmic Reticulum (ER) is a cellular organelle responsible for the synthesis and folding of secretory proteins. When protein import into the ER exceeds the its protein folding capacity, misfolded proteins accumulate and can potentially become toxic to the cell. This situation, termed ER stre...2019
162 Bernardo, Madeline F.The Neural Mechanisms of Sexual Transformation in Thalassoma Bifasciatum, the Bluehead WrasseThalassoma bifasciatum, the bluehead wrasse, is a protogynous sequential hermaphrodite and a commonly used model for studying environmental sex determination and adult sexual plasticity. Terminal phase (TP) male bluehead wrasses demonstrate characteristic behaviors and coloration changes when courti...2020
163 Bader, CecilyThe Response of Arabidopsis Mutant BPS1-2 on Salt MediaHow would our world change if salt tolerance could be engineered in plants? The Arabidopsis mutant bps1-2 has been shown to respond differently on salt media than a nonmutated plant would. In normal conditions, the bps1-2 mutant will arrest development in the root and shoot shortly after germination...2017
164 Russell, NicoleThe Role of Introns Within Alpha Conotoxin Genes in Cone SnailsCone snails, of which there are more than 600 species, have attracted a lot of attention. Cone snails, found in warm tropical waters across the world, are predators and produce venoms comprising diverse toxins. These toxins, termed conotoxins, have been the subject of a great amount of research. Whi...2016
165 Kannan, Sarmishta DiraviamThe Role that Lysosomes and Autophagy play in Alveolar soft parts Sarcoma, clear cell Sarcoma and Synovial SarcomaSarcomas are cancer of the connective tissue and are very deadly group of cancers. Two of the sarcoma types, alveolar soft parts sarcoma (ASPS) and clear cell sarcoma (CCS) have a unique vacuolar morphology. This unique morphology is absent in synovial sarcoma (SS). We believe that the unusual morph...2017
166 Yang, KevinThe Soluble (PRO) Renin Receptor does not Influence Lithium-Induced Diabetes Insipidus but does Provoke Beigning of White Adipose Tissue in MiceEarlier we reported that the recombinant soluble (pro) renin receptor sPRR-His upregulates renal aquoporin-2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy ...
167 Bell, Anthony W.The expansion of pinyon-juniper woodland and the appearance of peromyscus truel in the Toiyabe range of central NevadaIn the early twentieth century field biologists from the University of California Museum of Vertebrate Zoology conducted vertebrate faunal surveys throughout the Great Basin region. Over the past several years we have been conducting resurveys of many of the localities visited by MVZ scientists. Our...Piñon mouse -- Nevada -- Toiyabe Range; Piñon mouse -- Habitat -- Nevada -- Toiyabe Range; Piñon mouse -- Climatic factors -- Nevada -- Toiyabe Range2012-05
168 Pham, John V.The function of the protein VCP/CDC48-associated mitochondrial stress-responsive 1 in mammalsAlthough mitochondrial dysfunction has been linked to many human diseases, mitochondrial interacting proteins and protein quality controls are just beginning to be understood. The objective of our study was to characterize the function of the VMS1 protein in mammals. We determined the role of Vms1 o...Mitochondrial disorders; Mitochondrial diseases - genetics; VMS12012-05
169 Fox, ZachThe physical effects of solvent in molecule-based magnetsMolecule-based magnets are being studied in order to expand the utility of magnets in modern devices. Advantages of molecule-based magnets include less energy intensive synthesis and greater versatility through changes to organic components of the structure. This class of materials is studied to ena...Magnets - Experiments2012-05
170 Excell, KaterinaThe role of amyloid precursor protein in a model of alzheimer's diseaseAlzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ...2022
171 Nau, AdamThe role of heparan sulfate in maintaining stereotyped birdsongSong learning in Zebra Finches (Taeniopygia guttata) occurs during a critical period between 30-90 post hatch days, and involves acquisition of an acoustic model and a sensorimotor period of increasingly improving imitation of this model. Young birds sing highly variable songs early during this pe...Birdsongs - Research; Zebra finch - Research; Songbirds - Behavior; Heparan sulfate; Taeniopygia guttata; Neural circuitry2016-04
172 Du, WantongThe role of mRNA decay in a genetic switchGenes can be switched on or off by regulatory proteins. For example, two genes may each synthesize a protein that downregulates the other gene, creating a repressor- repressor switch that has two stable steady states: one being when the first gene is "on" and the second gene is repressed, and the ot...Messenger RNA - Research; Genetic regulation - Research; Genetic switch; Gene repression; Neural circuitry2016-04
173 Wang, ZhirongThe role of the autism-associated gene kirrel3 in synapse formationAlterations in the gene Kirrel3 are repeatedly associated with intellectual disability and autism. Kirrel3 regulates synapse formation in C. elegans but the role of Kirrel3 in synapse formation in the mammalian brain is unknown. In mice, Kirrel3 is expressed in specific cell types throughout the bra...Autism -- Genetic aspects; Synapses; Kirrel3 gene; Synapse formation2015-04
174 Aderibigbe, JustisTrends in the usage of bidentate phosphines as ligands in nickel catalysis of hydrogenation reactionsA critically important process in catalysis is the formation of an active catalyst from the combination of a metal precursor and a ligand, as the efficacy of this reaction governs the amount of active catalyst. This review is a compacted but comprehensive review of reactions catalyzed by nickel and ...2021
175 Scott, IsabelleTropical analog to the log canonical thresholdIn algebraic geometry, the log canonical threshold is a property of singularities of planar curves. While singularities have multiplicities, the log canonical threshold can be a more telling invariant. It helps to classify curves beyond what the multiplicity indicates by examining how quickly the in...Geometry, Algebraic2013-04
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