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Creator | Title | Description | Subject | Date |
| 151 |
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Frederick, Jeanne M. | Neurotransmitter properties of the newborn human retina. | Human retinal tissue from a newborn was examined autoradiographically for the presence of highaffinity uptake and localization of the following putative neurotransmitters: dopamine, glycine, GAB A, aspartate, and glutamate. In addition, the dopamine content of this newborn retina was measured by ... | Newborn; Human Retina; Neurotransmitter Properties; Photoreceptors | 1983 |
| 152 |
 |
Normann, Richard A. | Effects of GABA and related drugs on horizontal cells in the isolated turtle retina | The role of GABA in the outer plexiform layer of the turtle retina has been examined by intracellular recordings from L- and C-type horizontal cells in the isolated retina preparation. GABA (1-5 mM) slightly depolarized the L-type horizontal cells, reduced the amplitude of their photoresponses, and ... | Retina; Horizontal Cells; Synapse; Negative Feedback; GABA; Turtle | 1990 |
| 153 |
 |
Baehr, Wolfgang | Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel | We have determined the primary structures of the human and mouse retinal rod cGMP-gated cation channel by analysis of cDNA clones and amplified DNA. The open reading frames predicted polypeptides of 690 and 683 residues exhibiting 88% sequence similarity. Sequence comparison indicated that the rod c... | Restriction Mapping; Sequence Homology, Nucleic Acid; Chromosomes, Human, Pair 4 | 1992 |
| 154 |
 |
Baehr, Wolfgang | In vitro isoprenylation and membrane association of mouse rod photoreceptor cGMP phosphodiesterase alpha and beta subunits expressed in bacteria | We investigated the specificity of CAAX box-related isoprenylation of rod photoreceptor cGMP phosphodiesterase (PDE) subunits expressed in bacteria and the consequences of this modification on rod disk membrane association. Full-length cDNA sequences of the alpha and beta subunits of mouse PDE, inse... | Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data | 1992 |
| 155 |
 |
Mamalis, Nick; Nilson, Christian D. | Outbreak of toxic anterior segment syndrome following cataract surgery associated with impurities in autoclave steam moisture. | BACKGROUND: Toxic anterior segment syndrome (TASS), a complication of cataract surgery, is a sterile inflammation of the anterior chamber of the eye. An outbreak of TASS was recognized at an outpatient surgical center and its affiliated hospital in December 2002. METHODS: Medical records of patients... | Toxic anterior segment syndrome; cataract surgery; autoclave steam moisture | 2006 |
| 156 |
 |
Fuhrmann, Sabine | Expression of CNTF receptor-alpha in chick violet-sensitive cones with unique morphologic properties. | PURPOSE: Application of ciliary neurotrophic factor (CNTF) can rescue mature photoreceptors from lesion-induced and hereditary degeneration. In the chick retina, expression of the CNTF receptor is present in a subpopulation of photoreceptor cells. The present study was undertaken to identify the CNT... | embryology; cytology | 2004 |
| 157 |
 |
Baehr, Wolfgang | Trilateral tumors in four different lines of transgenic mice expressing SV40 T-antigen | PURPOSE. A line of transgenic mice containing the simian virus (SV) 40 T-antigen (T-ag) gene driven by the beta-luteinizing hormone (BLH) promoter developed bilateral retinoblastoma and primitive neuroectodermal tumors (PNET) of the midbrain. Midbrain tumors arose from the subependymal layer of the ... | Mice, Transgenic; Retinol-Binding Proteins; Eye Proteins | 1996 |
| 158 |
 |
Varner, Michael W.; Digre, Kathleen B. | Cranial magnetic resonance imaging in eclampsia. | Although the precise neuropathologic basis for eclamptic convulsions remains unclear, intracranial hemorrhage is frequently associated with fatal cases. Magnetic resonance imaging (MRI) is a recently developed neuroimaging technique that appears superior to other processes for defining intracranial ... | Eclampsia; Brain Edema; Cranial Magnetic Resonance Imaging | 1987-09 |
| 159 |
 |
Normann, Richard A.; Shoham, Shy | Coding of position by simultaneously recorded sensory neurones in the cat dorsal root ganglion | Muscle, cutaneous and joint afferents continuously signal information about the position and movement of individual joints. How does the nervous system extract more global information, for example about the position of the foot in space? To study this question we used microelectrode arrays to record... | Cats; Sensory Neurones; Movement; Limb Position | 2004 |
| 160 |
 |
Gouw, Launce G.; McKenna, Catherine K.; Digre, Kathleen B.; Placek, Louis J. | Analysis of the dynamic mutation in the SCA7 gene shows marked parental effects on CAG repeat transmission. | The gene for spinocerebellar ataxia 7 (SCA7) includes a transcribed, translated CAG tract that is expanded in SCA7 patients. We have determined expansions in 73 individuals from 17 SCA7 kindreds and compared them with repeat lengths of 180 unaffected individuals. Subjects with abnormal expansions co... | Genetics; Biosynthesis; SCA7 Gene | 1998-03-07 |
| 161 |
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Digre, Kathleen B.; Blumenthal, Deborah T.; Salzman, Karen L.; Jensen, Randy L.; Dunson, William A. | Early pathologic findings and long-term improvement in anti-Ma2-associated encephalitis. | A 67-year-old man sequentially developed anti-Ma2-associated paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule-assoc... | Paraneoplastic neurologic disorders; Encephalitis; Neoplasm;Herpes Simplex | 2006-07-11 |
| 162 |
 |
Digre, Kathleen B. | Not so benign intracranial hypertension. | Despite many controversies, intracranial hypertension due to use of doxycycline does occur. Practitioners prescribing the tetracyclic antibiotics should be aware of the syndrome of increased intracranial pressure, and pay particular attention to the ocular fundus for papilloedema. Appropriate referr... | Venous Occusion; Venous Hypertension; Tetracycline, Doxycycline; Minocycline | 2003-03-22 |
| 163 |
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Mamalis, Nick; Kleinmann, Guy; Chew, Jesse; Apple, David J. | Suturing a tear of the anterior capsulorhexis | AIM: To describe a new technique of suturing a tear in the anterior capsulorhexis. METHODS: Continuous curvilinear capsulorhexis (CCC) with lens removal was done in five fresh cadaver eyes. The diameter of the CCC was measured with a calliper. Using the same calliper a tear of the CCC was created wh... | Continuous curvilinear capsulorhexis; intraocular lens implantation; tear | 2006 |
| 164 |
 |
Kriesel, John D.; Spruance, Spotswood L.; Daynes, Raymond A. | Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease. | Nucleic acid vaccinations with plasmids pWW65, containing the sequence for herpes simplex type 2 (HSV-2) gD2, and pRSVnt, lacking the gD sequence, were studied. Groups of mice were immunized with pWW65 alone, pWW65 plus 1,25-dihydroxyvitamin-D3 (D3), or pRSVnt. Clinical disease (vaginitis), serum an... | Mice, Inbred BALB C; Plasmids; Viral Vaccines | 1996 |
| 165 |
 |
Bernstein, Paul S.; Gellermann, Werner | Nonmydriatic fluorescence-based quantitative imaging of human macular pigment distributions. | We have developed a CCD-camera-based nonmydriatic instrument that detects fluorescence from retinal lipofuscin chromophores ("autofluorescence") as a means to indirectly quantify and spatially image the distribution of macular pigment (MP). The lipofuscin fluorescence intensity is reduced at all ret... | Cytology; Sensitivity and Specificity | 2006-10 |
| 166 |
 |
Frederick, Jeanne M. | RNA interference gene therapy in dominant retinitis pigmentosa and cone-rod dystrophy mouse models caused by GCAP1 mutations | RNA interference (RNAi) knockdown is an efficacious therapeutic strategy for silencing genes causative for dominant retinal dystrophies. To test this, we used self-complementry (sc) AAV2/8 vector to develop an RNAi-based therapy in two dominant retinal degeneration mouse models. The allele-specific ... | | 2014-01-01 |
| 167 |
 |
Jones, Bryan W. | Online parameter estimation in dynamic Markov Random Fields for image sequence analysis | Markov Random Fields (MRF) have proven to be extremely useful models for efficient and accurate image segmentation.Recent literature points to an increased effort towards incorporating useful priors (shape, geometry, context) in a MRF framework. However, topological priors, considered extremely cruc... | | 2012-01-01 |
| 168 |
 |
Bernstein, Paul S. | Reflection-based imaging of macular pigment distributions in infants and children | We have developed a reflection-based capability of the RetCam® platform, an FDA-cleared pediatric retinal-imaging instrument, for the purpose of measuring macular pigment levels as well as their spatial distributions in infants and children. Our modifications include narrow-band blue-wavelength exc... | | 2013-01-01 |
| 169 |
 |
Durney, Carl H. | A computer graphics method for solving transcendental equations | There are a number of ways to determine the values of x which satisfy the equation F(x)=0. (The case of interest here is that in which F i s a complex function of the complex variable x.) One way is to search for values of x which make Real (F(x)) and Imaginary (F(x)) both zero at the same time wher... | Transcendental equations | 1970 |
| 170 |
 |
Angelucci, Alessandra | Experimentally induced retinal projections to the ferret auditory thalamus: development of clustered eye-specific patterns in a novel target | We have examined the relative role of afferents and targets in pattern formation using a novel preparation, in which retinal projections in ferrets are induced to innervate the medial geniculate nucleus (MGN). We find that retinal projections to the MGN are arranged in scattered clusters. Clusters a... | Retina; Ferrets | 1997 |
| 171 |
 |
Baehr, Wolfgang | Tissue-specific expression in transgenic mice directed by the 5'-flanking sequences of the human gene encoding interphotoreceptor retinoid-binding protein | Interphotoreceptor retinoid-binding protein (IRBP) is an extracellular protein that has been suggested to participate in the visual process as a carrier for visual retinoids. A chimeric gene composed of the human IRBP promoter fused to the bacterial reporter gene chloramphenicol acetyltransferase (C... | Restriction Mapping; Nucleic Acid Hybridization; Mice; Gene Expression | 1990-05-25 |
| 172 |
 |
Olson, Randall J. | Legacy AdvanTec and Sovereign WhiteStar: a wound temperature study | PURPOSE: To assess the wound temperature of the Sovereign WhiteStar (S-WS) (AMO) and Legacy AdvanTec (L-ADV) (Alcon) phacoemulsification systems. SETTING: John A. Moran Eye Center, Health Sciences Center, University of Utah, Salt Lake City, Utah, USA. METHODS: Phacoemulsification using 20-gauge, 30-... | Eye Burns; Wound Temperature; Phacoemulsification Systems | 2004-05 |
| 173 |
 |
Olson, Randall J.; Crandall, Alan S.; Mamalis, Nick | Intraoperative miotics and posterior capsular opacification following phacoemulsification with intraocular lens insertion | BACKGROUND AND OBJECTIVES: Posterior capsular opacification (PCO) is a frequent complication following phacoemulsification with intraocular lens (IOL) implantation. A series of consecutive patients receiving capsular bag-fixated, silicone IOL implants were assessed for both incidence of PCO and the ... | Intraocular Lens; Nd:YAG Laser Capsulotomy; Miochol; Miostat; Phacoemulsification; Posterior Capsular Opacification | 1997-11 |
| 174 |
 |
Zhang, Kang | Loss of ER retention and sequestration of the wild-type ELOVL4 by Stargardt disease dominant negative mutants | PURPOSE: Mutations in ELOVL4, a member of the fatty acid elongase (ELO) family, are responsible for autosomal dominant Stargardt-like macular degeneration. The specific role of ELOVL4 in photoreceptors and the degenerative events induced by dominant ELOVL4 mutations are not well understood. As a fir... | Macular Degeneration; Transcription Factor CHOP; Molecular Chaperones | 2005 |
| 175 |
 |
Normann, Richard A.; Horch, Kenneth W.; Cha, Kichul | Mobility performance with a pixelized vision system | A visual prosthesis, based on electrical stimulation of the visual cortex, has been suggested as a means for partially restoring functional vision in the blind. The prosthesis would create a pixelized visual sense consisting of punctate spots of light (phosphenes). The present study investigated the... | Visual Prosthesis; Mobility; Phosphene Simulator | 1992 |
