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Creator | Title | Description | Subject | Date |
151 |
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Capecchi, Mario R. | Critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice | Angiotensin-converting enzyme (ACE) generates the vasoconstrictor angiotensin II, which plays a critical role in maintenance of blood pressure in mammals. Although significant ACE activity is found in plasma, the majority of the enzyme is bound to tissues such as the vascular endothelium. We used ta... | Blood pressure; ACE activity; Enzyme | 1997-03-06 |
152 |
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Coley, Phyllis D.; Kursar, Thomas A. | Colonization of tropical rain forest leaves by epiphylls: effects of site and host plant leaf lifetime | In humid tropical regions, leaves are frequently colonized by epiphylls (Richards 1954, Pocs 1978, 1982). Lichens and liverworts usually dominate, although mosses, algae, and cyanobacteria can also occur (Winkler 1971, Smith 1982). The interactions between epiphylls and host leaves have not been wel... | Tropical forest; Epiphylls; Panama; Hybanthus prunifolius; Light interception | 1993 |
153 |
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Beckerle, Mary C.; Hoffman, Laura M. | Targeted disruption of the murine zyxin gene | Zyxin is an evolutionarily conserved protein that is concentrated at sites of cell adhesion, where it associates with members of the Enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) family of cytoskeletal regulators and is postulated to play a role in cytoskeletal dynamics and signaling. | Zyxin | 2003 |
154 |
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Capecchi, Mario R. | N-formylmethionyl-sRNA as the initiator of protein synthesis. | A bizarre fast about Nterminal groups of bacterial proteins. Instead of a random mixture, that the great majority of N-terminal groups were either methionine or alanine. This finding suggested that methionine and alanine constituted start signals for the initiation of polypeptide chains. Alternative... | Electrophoresis; Formates; In Vitro; Methionine | 1966-01-01 |
155 |
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Capecchi, Mario R. | Mice lacking endothelial angiotensin-converting enzyme have a normal blood pressure | To test the hypothesis that local vascular production of angiotensin II is necessary for the normal regulation of blood pressure, we engineered a new line of genetically altered mice that lack endothelial angiotensin-converting enzyme (ACE). This was accomplished using a novel strategy of targeted... | | 2002 |
156 |
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Adler, Frederick R. | Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics | Abstract Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alter... | | 2011 |
157 |
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Hughes, Kelly T. | Flagellar anti-σ factor FlgM actively dissociates Salmonella typhimurium σ28 RNA polymerase holoenzyme | The anti-σ factor FlgM of Salmonella typhimurium inhibits transcription of class 3 flagellar genes through a direct interaction with the flagellar-specific σ factor, σ28. FlgM is believed to prevent RNA polymerase (RNAP) holoenzyme formation by sequestering free σ28. We have analyzed FlgM-media... | sigma-factors; transcription; FlgM; Flagellum | 1998 |
158 |
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Beckerle, Mary C. | Identification of a new protein localized at sites of cell-substrate adhesion | A new protein found at sites of cellsubstrate adhesion has been identified by analysis of a nonimmune rabbit serum. By indirect immunofluorescence this serum stains focal contacts (adhesion plaques) and the associated termini of actin filament bundles in cultured chicken cells. | Actin; Nonimmune rabbit serum; Polypeptide | 1986 |
159 |
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Beckerle, Mary C.; Yoshigi, Masaaki; Hoffman, Laura M.; Yost, H. Joseph | Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement | Organs and tissues adapt to acute or chronic mechanical stress by remodeling their actin cytoskeletons. Cells that are stimulated by cyclic stretch or shear stress in vitro undergo bimodal cytoskeletal responses that include rapid reinforcement and gradual reorientation of actin stress fibers; howev... | Zyxin; Actin | 2005 |
160 |
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Goller, Franz | Contributions of expiratory muscles to song production in zebra finches | Birdsong production requires coordinated activity of syringeal and respiratory muscles, Phonation occurs during the expiratory phase of the respiratory cycle, and expiratory muscles generate the pressure head for sound production. | Phonation; Syringeal muscles; Air sac pressure | 1999 |
161 |
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Jorgensen, Erik | Function and misfunction of the two promoters of the Drosophila Antennapedia gene | In the Antennapedia (Antp) gene of Drosophila melanogaster, structurally distinct RNAs arise from different transcription initiation sites. When the two sites are separated by a chromosome inversion, transcripts are produced from each fragment of the split Antp locus, and these RNAs initiate at the ... | RNA; Antp; Hybridization | 1987 |
162 |
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Seger, Jon | Sexual dimorphism in the Hymenoptera | Spectacular sex differences of many kinds occur abundantly among the wasps, bees and ants that make up the insect order Hymenoptera. In some cases these differences are so extreme that males and females of the same species have been classified in different genera for decades, until a chance observa... | Reproductive; Insect; Morphology | 1994 |
163 |
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Davidson, Diane W. | Ecological studies of neotropical ant-gardens | In a census taken in Peru's Manu National Park, 10 epiphytic angiosperms from seven plant families established principally on arboreal carton-ant nests. These "ant gardens" (AGs) were most often inhabited by parabiotic ants, Camponotus femoratus and Crematogaster cf. limata parabiotica, whose polygy... | Ant competition; Ant garden; Ant-plant interaction; Coadaptation; Epiphyte; Mutualism; Parabiosis; Preadaptation; Peru; Seed dispersal; Tropical rainforest | 1988 |
164 |
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Olivera, Baldomero M.; Gray, William Robert | Conotoxin MI: disulfide bonding and conformational states | The toxic peptide from Conus magus venom (conotoxin MI) is a 14-amino acid peptide (McIntosh, M., Cruz, L. J., Hunkapiller, M. W., Gray, W. R., and Olivera, B. M. (1982) Arch. Biochem. Biophys. 218, 329-334) which inhibits the acetylcholine ceptor. In this work we have confirmed the primary structu... | Conotoxins; Disulfide bonding; Venom; Conus magus | 1983 |
165 |
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Beckerle, Mary C. | Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression | Members of the cysteine-rich protein (CRP) family are evolutionarily conserved proteins that have been implicated in the processes of cell proliferation and differentiation. In particular, one CRP family member has been shown to be an essential regulator of cardiac and skeletal muscle development. | LIM domains; Chicken fibroblasts; Zyxin; Actinin; Protein expression; Cysteine-rich proteins | 1997 |
166 |
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Olivera, Baldomero M. | Preliminary study of Conus venom protein | ALTHOUGH THE TOXICITY of venoms of the genus Conus has been known since a report by RUMPHIUS in 1705 (VAN BENTHEM-JUTTINO, 1959), these venoms have been studied only intermittently since. Biochemical studies have not been carried out to any great extent; the last major study on the biochemistry of... | Conotoxins; Conus venom | 1976 |
167 |
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Capecchi, Mario R. | Introduction: the molecular genetic analysis of mouse development | This paper is an introduction of seven different papers presented in "Seminars in developmental biology" on Molecular Genetic Analysis of Mouse Development . The first paper, by Janet Rossant, describes very early mouse development. The second paper, by Frank Conlon and Rosa Beddington provide an i... | Embryo Culture Techniques; Genes | 1995-04 |
168 |
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Clayton, Dale H. | Reciprocal natural selection on host-parasite phenotypes | Coevolution is evolution in one species in response to selection imposed by a second species, followed by evolution in the second species in response to reciprocal selection imposed by the first species. Although reciprocal selection is a prerequisite of coevolution, it has seldom been documented in... | Host-parasite phenotypes; Ectoparasites; Virulence; Fitness | 1999 |
169 |
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Capecchi, Mario R. | Mice with enhanced macrophage angiotensin-converting enzyme are resistant to melanoma | Angiotensin-converting enzyne (ACE) is a pepitdase responsible for the cleavage of angiotensin I and Several other peptides. Here, gene targeting was used to switch control of the ACE locus from the endogenous promoter to the macrophage-specific c-fms promoter. Challenge of these mice, called ACE 10... | Macrophage enzyme; Melanoma resistance; Enhanced macrophage angiotensin-converting enzyme | 2007 |
170 |
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Davidson, Diane W. | Species diversity and community organization in desert seed-eating ants | Patterns of species diversity and community organization in desert seed-eating ants were studied in 10 habitats on a longitudinal gradient of increasing rainfall extending from southeastern California, through southern Arizona, and into southwestern New Mexico. Local communities of harvester ants... | Ants; Arizona; California; Communities; Competition; Desert Granivores; Diversity; Insects; New Mexico; Novomessor; Pheidole; Pogonomyrmex; Resource allocation; Veromessor. | 1977 |
171 |
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Carrier, David R. | Human flight and exercise in microgravity | Early experimenters in human flight learned, sometimes with fatal consequences, that the human body lacks the muscular power to fly (1). Indeed, the power demands are so great that only relatively small animals (less than 12 kg) are able to fly actively due to the interplay of morphologic scaling (m... | Human flight; Microgravity | 2000 |
172 |
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Potts, Wayne K. | Consequences of self and foreign superantigen interaction with specific VB elements of the murine TCR aB | The aB T-cell receptor (TCRaB) recognizes a ligand composed of an antigen fragment complexed with a product of the major histocompatibility complex (MHC). The repertoire of receptors is limited both by the germ line of receptor variable elements and by selective events that take place during T-cell ... | Toxins; Repertoire; Expression | 1989 |
173 |
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Davidson, Diane W. | Ant-plant symbioses in Africa and the neotropics : history, biogeography and diversity | Symbiotic ant-plant relationships afford an excellent opportunity to analyze the effects of both historical and ecological factors on the evolution of mutualisms. Occurring in tropical forests throughout the world, all myrmecophytic plants provide food and permanent housing to ants; the ants, in t... | Ant-plant symbiosis; Africa; Neotropics; Myrmecophytes; Plant-ants | 1993 |
174 |
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Shapiro, Michael D. | Divergence, convergence, and the ancestry of feral populations in the domestic rock pigeon | Domestic pigeons are spectacularly diverse and exhibit variation in more traits than any other bird species [1]. In The Origin of Species, Charles Darwin repeatedly calls attention to the striking variation among domestic pigeon breeds - generated by thousands of years of artificial selection on a s... | | 2010 |
175 |
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Coley, Phyllis D. | Tritrophic interactions in tropical versus temperate communities | The latitudinal gradient in diversity is one of the oldest (e.g., Wallace, 1878) and most obvious trends in ecology, and a wealth of literature is devoted to understanding both the causes and consequences of this gradient (Dobzhansky, 1950; also reviewed by Rohde, 1992). Given the enormous latitudi... | Tritrophic interactions; Trophic cascades; Herbivory; Tropical communities; Temperate communities | 2002 |