Collection of materials relating to neuro-ophthalmology as part of the Neuro-Ophthalmology Virtual Education Library.
NOVEL: https://novel.utah.edu/
TO
- NOVEL716
| Title | Creator | Description | Subject | ||
|---|---|---|---|---|---|
| 126 |
 |
Myasthenia Gravis (Guest Lecture) | Shirley H. Wray, MD, PhD, FRCP | The patient is a 46 year old woman who presented in July 1977 with horizontal double vision lasting two weeks. Three weeks later the left upper eyelid started to droop and by the end of the day the eye was closed. She had no ptosis of the right eye and no generalized fatigue. She consulted an intern... | Unilateral Ptosis; Unilateral Lid Retraction; Myasthenic Lid Twitch; External Ophthalmoplegia; Ocular Myasthenia Gravis; Tensilon Test; Thymolipoma; Generalized Myasthenia Gravis; Unilateral Myasthenia Gravis; Myasthenic Ptosis; Lid Retraction; Lid Twitch |
| 127 |
 |
Bilateral Ptosis | Shirley H. Wray, MD, PhD, FRCP | This case, previously reported in 2007, is published courtesy of John Newsom-Davis, M.D., FRCP, FRS, CBE. Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford. This patient was unusual in presenting in early childhood and the development of persistent facial muscle and tongue ... | Bilateral Ptosis; Full Eye Movements; Facial Weakness; Tongue Atrophy; MuSK Antibody Myasthenia Gravis |
| 128 |
 |
Ocular Myasthenia Gravis (Guest Lecture) | Shirley H. Wray, MD, PhD, FRCP | See also: http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/264, http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/337, http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/332, http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/265, and http://content.lib.utah.edu/cd... | Unilateral ptosis; Positive tensilon test; Ocular Myasthenia Gravis; Unilateral Myasthenia Gravis; Ptosis -- Myasthenic Pseudo-internuclear Ophthalmoplegia; Bilateral Weakness of Adduction; Tensilon Test; Bilateral Myasthenia Gravis; Internuclear Ophthalmoplegia; Familial Myasthenia Gravis;... |
| 129 |
 |
Horizontal Gaze Palsy | Shirley H. Wray, MD, PhD, FRCP | This 56 year old woman with known adenocarcinoma of the breast presented with the recent onset of horizontal diplopia and deviation of her left eye inwards. Her oncologist referred her for a neuro-ophthalmic evaluation. This 56 year old woman with known adenocarcinoma of the breast presented with th... | Unilateral Horizontal Gaze Palsy; Esotropia; Fascicular Sixth Nerve Palsy; Horizontal Gaze Evoked Nystagmus; Normal Convergence; Horizontal Oculocephalic Reflexes Absent; Facial Palsy (Bell's Palsy); Abducens Nuclear Lesion; Pontine Metastasis; Adenocarcinoma of the Breast; Unilateral Sixth Nerve Pa... |
| 130 |
 |
One and a Half Syndrome | Shirley H. Wray, MD, PhD, FRCP | Slideshow describing condition. | Abducens Nuclear Lesion; Abducting Nystagmus; Cavernous Angioma; Convergence Absent; Convergence Normal; Esotropia; Facial Palsy; Facial Weakness; Fisher's One-and-a-Half Syndrome; Gaze Evoked Upbeat Nystagmus; Multiple Sclerosis; Pendular Vertical Oscillations; Pontine Hemorrhage; Pontine Infarct;... |
| 131 |
 |
Chiari I Malformation | Shirley H. Wray, MD, PhD, FRCP | See also: http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/295, http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/323, and http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/61 | Downbeat Nystagmus; Oscillopsia; Chiari-1 Malformation; Primary Position Downbeat Nystagmus; Vertical Saccadic Dysmetria; Horizontal Saccadic Dysmetria; Ataxia; Dysmetria; Chiari Malformation |
| 132 |
 |
Carotid Cavernous Fistulas (PowerPoint) | AAO/NANOS - American Academy of Ophthalmology / North American Neuro-Ophthalmology Society | This 76-year-old woman has a 7-month history of redness and pressure sensation in both eyes that is worse in the morning. She has noted intermittent horizontal diplopia during this time. Angiography demonstrated a right dural cavernous sinus fistula, which was successfully occluded with direct injec... | Dural Arteriovenous Malformation; Carotid Cavernous Fistulas |
| 133 |
 |
Leber's Optic Neuropathy (PowerPoint) | AAO/NANOS - American Academy of Ophthalmology / North American Neuro-Ophthalmology Society | Several Primary Mutations result in Leber's hereditary optic neuropathy, including mitochondrial deletions at positions 11778, 3460, and 14484. Although the 11778 is the most common mutation, the 11484 has the best prognosis for spontaneous recovery. This case exhibits the 3460 mutation. | Leber's Optic Neuropathy |
| 134 |
 |
Mitochondrial Myopathy | Shirley H. Wray, MD, PhD, FRCP | A PowerPoint slideshow describing the condition. | Bilateral Progressive External Ophthalmoplegia (PEO); Bilateral Ptosis; Cerebellar Degeneration with Ataxia; Complete External Ophthalmoplegia; External Ophthalmoplegia Affecting Upgaze; Facial Weakness; Kearns-Sayre Syndrome; Mitochondrial Myopathy; Normal Pupils; PEO plus Atypical Retinitis Pigm... |
| 135 |
 |
Transient Monocular Blindness (Guest Lecture) | Shirley H. Wray, MD, PhD, FRCP | See also: http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/293 and http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/96 | Retinal Emboli; Transient Monocular Blindness; Ocular Stroke; Transient; Transient Visual Loss; Sunlight Provoked Transient Monocular Blindness; Low Pressure Retinopathy; Ipsilateral Internal and External Carotid Occlusive Disease; Ischemic Eye Syndrome; Retinal Stroke; Ocular Ischemic Sy... |
| 136 |
 |
Congenital Horizontal Gaze Palsy, Progressive Scoliosis | Shirley H. Wray, MD, PhD, FRCP | The patient is an 8 year old boy with a rare autosomal recessive disorder characterized by congenital absence of conjugate horizontal eye movements preservation of vertical gaze and convergence and progressive scoliosis (HGPPS) developing in childhood. The child was referred to Dr. Cogan with a diag... | Congenital Horizontal Gaze Palsy; Progressive Scoliosis; Mutation of the ROBO 3 Gene on Chromosome 11q23-q25; Congenital Cranial Disinnervation Syndrome; Mobius Syndrome |
| 137 |
 |
Convergence Insufficiency | Shirley H. Wray, MD, PhD, FRCP | The patient is a 73 year old man with a ten year history of idiopathic Parkinson's disease characterized by difficulty in walking, generalized rigidity and a mild tremor of his hands at rest with deterioration in his handwriting. He denied any memory impairment or loss of cognitive function. He was ... | Basal Ganglia; Blepharoclonus; Convergence Insufficiency; Slow Hypometric Saccades; Saccadic Breakdown of Smooth Pursuit; Parkinson's Disease- Dopamine deficiency; Slow Hypometric Horizontal Saccades; Convergence |
| 138 |
 |
Blepharospasm Round-Up (Guest Lecture) | Shirley H. Wray, MD, PhD, FRCP | The patient is a 60 year old estate manager with a history of retinal laser therapy, dry eyes and age related bilateral ptosis. He carries a diagnosis of hilar lymphadenopathy due to sarcoid and has had cancer of the kidney. He presented in 1995 with a 6 month history of frequent blinking and spasms... | Benign Essential Blepharospasm; Focal Dystonia; Blepharospasm |
| 139 |
 |
Eyebrow Spasm (Guest Lecture) | Shirley H. Wray, MD, PhD, FRCP | This case is published courtesy of Daniel J. Costello, M.D., Department of Neurology, Massachusetts General Hospital, Boston. The patient is a 32-year-old right-handed man with an established diagnosis of Tuberous Sclerosis Complex characterized by: -medically intractable epilepsy -developmental del... | Rhythmic Eyebrow Spasm; Torsional Nystagmus; Primary Position Left Beating Nystagmus; Epileptic Seizures; Tuberous Sclerosis Complex (TSC-2 DNA sequence variant); Bipolar Affective Disorder |
| 140 |
 |
Cavernous Sinus Meningioma | Shirley H. Wray, MD, PhD, FRCP | This patient is a 46 year old woman from Portugal who was admitted to the Massachusetts General Hospital in September 1986 with ophthalmoplegia of the left eye (OS) and signs of aberrant reinnervation of the third nerve. She presented, in August 1985, with an episode of diplopia. The diplopia was su... | Ptosis; Unilateral Third Nerve Palsy; Aberrant Reinnervation of the Third Nerve; Paresis of Abduction; Sixth Nerve Palsy; Oculomotor Nerve; Cavernous Sinus Meningioma; Cavernous Sinus Syndrome; Unilateral Oculomotor Third Nerve Palsy; Unilateral Sixth Nerve Palsy |
| 141 |
 |
CNS Lymphoma | Shirley H. Wray, MD, PhD, FRCP | The patient is a 70 year old Italian man with atrial fibrillation on long-term coumadin therapy. In October 1995, he developed generalized headache, horizontal double vision and his left eye deviated inwards (esotropia). A diagnosis of left sixth nerve palsy was made and attributed to microvascular ... | Bilateral Sixth Nerve Palsy; Bilateral Esotropia; CNS Non-Hodgkin's Lymphoma; Cavernous Sinus Syndrome; Lymphoma |
| 142 |
 |
Aneurysms | AAO/NANOS - American Academy of Ophthalmology / North American Neuro-Ophthalmology Society | Aneurisms may result in neuro-ophthalmologic sign and symptoms by direct compression of the afferent or efferent systems or by the secondary effects of hemorrhage. Basilar aneurisms may result in ocular motor deficits such as a unilateral or bilateral third nerve palsy. | Aneurysm |
| 143 |
 |
Bilateral Internuclear Ophthalmoplegia | Shirley H. Wray, MD, PhD, FRCP | This patient was seen at the Yale Eye Center at the age of 37. She had a long history of multiple sclerosis. At age 22, she had an acute attack of optic neuritis in the left eye which recovered fully within three weeks. Some months later she had a recurrent episode in the same eye, which also recove... | Bilateral Internuclear Ophthalmoplegia; Pendular Horizontal Oscillations; Lid Nystagmus; Upbeat Nystagmus; Botulinum Toxin Therapy; Multiple Sclerosis; Horizontal Pendular Nystagmus; Gaze Evoked Upbeat Nystagmus; Abducting Nystagmus |
| 144 |
 |
Internuclear Ophthalmoplegia in Childhood (Guest Lecture) | Shirley H. Wray, MD, PhD, FRCP | This case was reported by Cogan DG and Wray SH. Internuclear ophthalmoplegia as an early sign of brain tumor. Neurology 1970; 20:629-633. The patient is Case 1. He is a 4 ½ year old boy whose parents noted that the right eye had been "drifting" for four months. On examination the only significant f... | Bilateral Internuclear Ophthalmoplegia; Upbeat Nystagmus; Medulloblastoma; Abducting Nystagmus |
| 145 |
 |
Supranuclear Paralysis of Vertical Gaze | Shirley H. Wray, MD, PhD, FRCP | This case was presented to the Clinical Eye Movement Society at the American Neurological Association Meeting in October 2007. The patient is a healthy, 36 year old Lieutenant Commander in the Coast Guard who was last seen perfectly well at 2 a.m. on the day of admission. He awoke in the morning aro... | Somnolence; Global Supranuclear Paralysis of Vertical Gaze; Absent Vertical Saccades and Pursuit Movements; Intact Convergence; Convergence Retraction Nystagmus; Ocular Dysmetria; Ocular Tilt Reaction; Lateropulsion; Unilateral Midbrain and Thalamic Infarct; Supranuclear Paralysis of Up and Downgaze... |
| 146 |
 |
Supranuclear Paralysis of Downgaze | Shirley H. Wray, MD, PhD, FRCP | John Trojanowski and I published this case in Neurology in 1980.(12) At that time, it was one of the first of five reports in the literature of the pathological localization of lesions in the midbrain that are responsible for selective supranuclear paralysis of downgaze. This case is of particular i... | Somnolence; Supranuclear Paralysis of Downgaze; Vertical Oculocephalic Reflex Normal; Absent Convergence; Skew Deviation; Ocular Tilt Reaction; Artery of Percheron; Midbrain Infarct; Supranuclear Paralysis of Downgaze Infarct |
| 147 |
 |
Third Nerve Palsy | Shirley H. Wray, MD, PhD, FRCP | Slideshow describing condition. | Heubner's Arteritis; Meningovascular Syphilis; Oculomotor Nerve; Ptosis; Third Nerve Microinfarct; Unilateral Oculomotor Third Nerve Palsy; Unilateral Third Nerve Palsy |
| 148 |
 |
Whipples Disease (Guest Lecture) | Shirley H. Wray, MD, PhD, FRCP | The patient is a 44 year old woman with a past history of ethanol abuse. She was transferred to the Massachusetts General Hospital (MGH) on 3/10/93 for evaluation of memory impairment, hypothalamic dysfunction and a one month history of diplopia and ataxia. In February 1992 (13 months PTA), she deve... | Somnolence; Supranuclear Paralysis of Up and Downgaze; Vertical gaze palsy (c); Absent convergence; Pendular vergence oscillations; Bilateral lid nystagmus; Tropheryma Whippelii - Infection; CNS Whipple's Disease; Supranuclear Paralysis of Up and Downgaze Infection-Whipple's Disease |
| 149 |
 |
Progressive Supranuclear Palsy | Shirley H. Wray, MD, PhD, FRCP | See also: http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/316, http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/241, http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/32, http://content.lib.utah.edu/cdm/ref/collection/ehsl-shw/id/81, http://content.lib.utah.edu/cdm/ref/... | Apraxia of Eyelid Opening; Impaired Initiation of Horizontal Saccades; Slow Hypometric Horizontal Saccades; Supranuclear Paralysis of Up and Downgaze Degeneration; Progressive Supranuclear Palsy - Tauopathy; Steele Richardson Olszewski Syndrome; CNS - Degeneration; Square wave Jerks; Supranu... |
| 150 |
 |
Claude's Syndrome | Shirley H. Wray, MD, PhD, FRCP | The patient is a 76 year old woman who woke one morning unable to see out of her right eye because of ptosis. She came to the Massachusetts General Hospital emergency room and was admitted. Neurological Examination: Right third nerve palsy involving the pupil Ataxia of the left hand on finger-nose t... | Ptosis; Fascicular Third Nerve Palsy; Fixed Dilated Pupil; Contralateral Limb Ataxia; Claude Syndrome; Midbrain Infarct; Oculomotor Nerve; Unilateral Third Nerve Palsy; Subnuclear; Fascicular Oculomotor (Third) Nerve Palsy |