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126 Baehr, WolfgangHuman interstitial retinoid-binding protein. Gene structure and primary structureInterstitial retinoid-binding protein (IRBP) is synthesized and secreted by rod photoreceptor cells into the interphotoreceptor matrix and is known to bind retinoids and fatty acids. We have used cDNA clones encoding human IRBP to isolate a 15-kilobase genomic fragment that encompasses the complete ...Molecular Sequence Data; Eye Proteins; Retinol-Binding Proteins; Messenger RNA1989-05-15
127 Olivera, Baldomero M.; Parks, Thomas N.Conantokin-T: a γ-carboxyglutamate containing peptide with N-methyl-D-aspartate antagonist activityConantokin-T, a 21-amino acid peptide which induces sleep-like symptoms in young mice was purified from the venom of the fish-hunting cone snail, Conus tulipa. The amino acid sequence of the peptide was determined and verified by chemical synthesis. The peptide has 4 residues of the modified amino ...Conotoxins; Conantokin-T; N-methyl-D-aspartate antagonist; Conus tulipa1990
128 Bohs, Lynn A.Systematics of Solanum section Allophyllum (Solanaceae)Three species of Solarium are included in a new section, Solarium sect. Allophyllum. Two of the species, S. allophyllum and S. mapiriense, have been previously known; the third, S. morellifolium Bohs, is described as new. The combination of characters exhibited by members of this section, such as un...Solanum section Allophyllum; Solanum allophyllum; Solanum morellifolium; Solanum mapiriense1990
129 Olivera, Baldomero M.DNA-topoisomerase modificationThe first reports of topoisomerase modification were published in 1982 and 1983 (Mills et al. 1982; Durban et al. 1983; Ferro et al. 1983; Jongstra-Bilen et al. 1983). Although a wide variety of posttranslational modifications of DNA topoisomerases may occur, this chapter focuses only on phosphoryl...Poly(ADP-ribosylation); Serine residues1990
130 Potts, Wayne K.Surprisingly uneven distribution of the T cell receptor Vβ repertoire in wild miceHeterodimeric TCRa/Bs are made up of combinations of V D, J, and C elements. The majority of laboratory inbred mouse strains are of the VBh haplotype and have at least 20 VB genes from which to construct TCRs (1, 2); however, a number of strains have been reported to have deletions of large portion...1990
131 Blair, David F.MotA protein of E. coli is a proton-conducting component of the flagellar motorA number of mutants of motA, a gene necessary for flagellar rotation in E. coli, were isolated and characterized. Many mutations were dominant, owing to competition between functional and nonfunctional MotA for a limited number of sites on the flagellar motor. A new class of mutant was discovered...MotA protein; MotA gene; Flagellar motor; Proton-conducting1990
132 Beckerle, Mary C.Adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to the tumor-promoting phorbol esterTalin is a high molecular weight phosphoprotein that is localized at adhesion plaques. We have found that talin phosphorylation increases 3.0-fold upon exposure of chicken embryo fibroblasts to the tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate.Talin; Vinculin; Chicken embryo fibroblasts1990
133 Capecchi, Mario R.Gene targeting: tapping the cellular telephone.Gene targeting means that we now have the potential to generate mice of virtually any desired genotype. In the first instance, standards recombinant DNA technology is used to alter a cloned DNA sequence of a chosen locus; the modified potent stem cell derived from a mouse embryo, and homologous reco...Animals; Blotting, Southern; Bone and Bones; Gene Targeting; Genotype; Immunochemistry; In Situ Hybridization; Mice1990-03-08
134 Baehr, WolfgangTissue-specific expression in transgenic mice directed by the 5'-flanking sequences of the human gene encoding interphotoreceptor retinoid-binding proteinInterphotoreceptor retinoid-binding protein (IRBP) is an extracellular protein that has been suggested to participate in the visual process as a carrier for visual retinoids. A chimeric gene composed of the human IRBP promoter fused to the bacterial reporter gene chloramphenicol acetyltransferase (C...Restriction Mapping; Nucleic Acid Hybridization; Mice; Gene Expression1990-05-25
135 Thomas, Kirk R.; Capecchi, Mario R.Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.The int-1 proto-oncogene was first identified as a gene activated in virally induced mouse mammary tumours. Expression studies, however, suggest that the normal function of this gene may be in spermatogenesis and in the development of the central nervous system. Genes sharing sequence similarity wit...Animals; Blastocyst; Cell Line; Chimera; DNA; Female; Genotype; Heterozygote; Homozygote; Male; Mice, Inbred C57BL; Motor Activity1990-08-30
136 Mansour, Suzanne L.; Thomas, Kirk R.; Capecchi, Mario R.Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.We demonstrate that the frequency of gene targeting is unaffected by the length of nonhomologous DNA transferred to a target chromosomal sequence. A result of this finding is that a much wider spectrum of designed genomic alterations is now feasible. As a first application, we inserted a 5.4-kilobas...Blotting, Southern; Cell Differentiation; Fluorescent Antibody Technique; Restriction Mapping1990-10
137 Capecchi, Mario R.Gene targeting. How efficient can you get?With targeting in Leishmania and Trypanosoma, there are now greater incentives to develop the technology in organisms of intermediate complexity such as Caenorhabditis elegans and Drosophila. The ratio of homologous to nonhomologus recombination in these organisms might prove to be greater than in m...Animals; DNA Mutational Analysis; Recombination, Genetic1990-11-08
138 Bohs, Lynn A.Crossing studies in Cyphomandra (Solanaceae) and their systematic and evolutionary significanceA crossing program involving eight species of Cyphomandra was instituted to elucidate systematic relationships between the taxa and evolutionary mechanisms operating in the genus. The results show that gametophytic self-incompatibility is widespread in Cyphomandra. Pollen tubes were able to reach ...Solanum maternum; Crossing studies1991
139 Olivera, Baldomero M.; Hillyard, David R.ConotoxinsMany successful animal and plant families have developed distinctive biochemical strategies; one of the more unusual examples is found in a group of marine gastropods, the cone snails (Conus) (1). These animals have evolved a specialized biochemistry of small constrained peptides, the conotoxins. Th...Conotoxins1991
140 Gesteland, Raymond F.; Atkins, John F.Frameshifting in gene 10 of bacteriophage T7Gene 10 of bacteriophage T7, which encodes the most abundant capsid protein, has two products: a major product, 10A (36 kDa), and a minor product, 10B (41 kDa). 10B is produced by frameshifting into the -1 frame near the end of the 10A coding frame and is incorporated into the capsid. The frameshift...Frameshifting; Bacteriophage T7; RNA, Viral; Gene Expression1991
141 Bastiani, MichaelDevelopmental expression of REGA-1, a regionally expressed glial antigen in the central nervous system of grasshopper embryosGlial cells are a large component of the developing nervous system, appearing before the onset of axon outgrowth in a variety of developing systems. Their time of appearance and their location in conjunction with developing axon pathways may allow them to define the position of axon pathways.Antibody; Axons; Pathways1991
142 Capecchi, Mario R.; Thomas, Kirk R.Swaying is a mutant allele of the proto-oncogene Wnt-1Mice homozygous for the recessive mutation swaying (SW) are characterized by ataxia and hypertonia, attributed to the malformation of anterior regions of the cerebellum. We show that SW is a deletion of a single base pair from the proto-oncogene Wnf-1. The deletion is predicted to cause premature t...Swaying allele; protooncogene Wnt-1; Mutant genes; Mutant alleles1991
143 Capecchi, Mario R.Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5.Gene targeting in mouse embryo-derived stem cells has been used to disrupt the homeobox gene hox-1.5. Mice heterozygous at the hox-1.5 locus appear normal, whereas hox-1.5-/hox-1.5- mice die at or shortly after birth. These homozygotes are athymic, aparathyroid, have reduced thyroid and submaxillary...Abnormalities, Multiple; Animals, Newborn; Arteries; Bone and Bones; Cartilage; Esophagus; Gene Expression; Heart Defects, Congenital; Organ Specificity; Parathyroid Glands; Pharynx; Thymus Gland; Thyroid Gland; Trachea1991-04-11
144 Capecchi, Mario R.Lessons from angiotensin-converting enzyme-deficient mice.Mice which lack ACE have low systolic blood pressure, reduced male fertility and a renal abnormality characterized by medullary hypoplasia and the inability to concentrate urine. The diverse phenotypes caused by inactivation of a single gene emphasize the many functional roles of ACE and the renin-q...Blood Pressure; Cell Line;Fertility; Kidney; Testis1991-11-01
145 Beckerle, Mary C.Zyxin and cCRP: Two interactive LIM domain proteins associated with the cytoskeletonInteraction with extracellular matrix can trigger a variety of responses by cells including changes in specific gene expression and cell differentiation. The mechanism by which cell surface events are coupled to the transcriptional machinery is not understood, however, proteins localized at sites o...Zyxin; Cysteine-rich proteins; cCRP; LIM domain1992
146 Adler, Frederick R.Information collection and spread by networks of patrolling antsTo study how a social group, such as an ant colony, monitors events occurring throughout its territory, we present a model of a network of patrolling ants engaged in information collection and dissemination. In this network, individuals follow independent paths through a region and can exchange sign...Patrolling network; ant colony; information-gathering1992
147 Davidson, Diane W.Experimental manipulation of food bodies in CecropiaNeotropical Cecropia trees range from Mexico to Argentina and are typical of disturbed habitats. Cecropia plants provide food and housing for the ants in return for known or presumed protection from herbivores and vine cover. Glycogen-rich Mullerian bodies (MB's) are the predominant food source for ...Mullerian bodies; Trichilia; Cecropia tessmannii; Cecropia pungara1992
148 Olivera, Baldomero M.Conus peptides: phylogenetic range of biological activityThe major function of the venoms of the predatory marine snails belonging to the genus Conus is to paralyze prey. Thus, the venom of each Conus species acts on receptors and ion channels of the prey; previous studies suggested much less activity on homologous receptor targets in more distant taxa....Conus peptides; Conopeptides; Conotoxins1992
149 Olivera, Baldomero M.; Hillyard, David R.Heterodimeric structure of the spider toxin ω-Agatoxin IA revealed by precursor analysis and mass spectrometryWe report the first molecular characterization of a precursor sequence for a small, Ca2+ channel blocking, peptide spider toxin, ω-agatoxin IA. By integrating information generated from a molecular genetic approach using agatoxin cDNAs with data provided from mass spectrometry of the mature tox...Spider toxin w-Aga-IA; Heterodimeric structure1992
150 Beckerle, Mary C.Interaction between zyxin and α-actininZyxin is an 82-kD protein first identified as a component of adhesion plaques and the termini of stress fibers near where they associate with the cytoplasmic face of the adhesive membrane. We report here that zyxin interacts with the actin cross-linking protein α-actinin.Zyxin; Actinin; Actin1992
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