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Creator | Title | Description | Subject | Date |
101 |
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Baehr, Wolfgang | Cloning of frog rod photoreceptor cGMP phosphodiesterase subunits (P-alpha, P-beta, P-gamma) and identification of P-gamma) sites involved in the stimulation of cGMP binding to P-alpha and P-beta non-catalytic sites | Retinal cGMP phosphodiesterase (PDE6) is a key enzyme in vertebrate phototransduction. Rod PDE contains two homologous catalytic subunits (Pd two identical regulatory subunits (P). Biochemical studies have shown that amphibian P has high affinity, cGMP-specific, non-catalytic binding sites and that ... | Phototransduction; Retinal cGMP phosphodiesterase; Amphibian PDE | 2002 |
102 |
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Olson, Randall J.; Spencer, Terrence S.; Mamalis, Nick | Three-year clinical comparison of 3-piece AcrySof and SI-40 silicone intraocular lenses | PURPOSE: To compare the 3-year performance of the 3-piece AcrySof (Alcon) and the SI-40 silicone (Allergan) intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. METHODS: In this retrospective study, patients with no complications and at least a... | Acrylic Resins; Silicone Elastomers; Prosthesis Design; Postoperative Complications; Patient Satisfaction; Cataract | 2002-07 |
103 |
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Angelucci, Alessandra; Lund, Jennifer S. | Circuits for local and global signal integration in primary visual cortex | Contrast-dependent changes in spatial summation and contextual modulation of primary visual cortex (V1) neuron responses to stimulation of their receptive field reveal long-distance integration of visual signals within V1, well beyond the classical receptive field (cRF) of single neurons. To identif... | Primary Visual Cortex; Extrastriate Cortex; Feed-back Connections; Lateral Connections; SUrround Modulation; Macaque | 2002-10-01 |
104 |
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Baehr, Wolfgang | Identification and light-dependent translocation of a cone-specific antigen, (Cone Arrestin) recognized by monoclonal antibody 7G6 | PURPOSE: To elucidate the antigen recognized by monoclonal antibody (mAb) 7G6, a widely used cone-specific marker. METHODS: 7G6 immunocytochemistry was performed on sections of human, primate, and bovine retina. The antigen was immunoprecipitated from human retinal lysates and purified with protein ... | Cones (Retina); Molecular Sequence Data; Phototransduction | 2003 |
105 |
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Baehr, Wolfgang | Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransduction | PURPOSE: The light-dependent redistribution of phototransduction components in photoreceptor cells plays a role in light adaptation. Upon illumination, rod and cone arrestins (Arr and cArr) translocate from the inner to the outer segments while transducin subunits (Talpha, Tbetagamma) translocate in... | Phototransduction; Protein Kinases; Rhodopsin Kinase | 2003 |
106 |
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Baehr, Wolfgang; Zhang, Kang | Elovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genes | PURPOSE: Stargardt-like macular dystrophy (STGD3) is an autosomal dominant form of early onset macular degeneration. The disease causing gene ELOVL4 encodes a protein that belongs to a family of proteins functioning in elongation of long chain fatty acids. The purpose of this study is to characteriz... | Amino Acid Sequence; Cloning, Molecular; Molecular Sequence Data | 2003 |
107 |
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Baehr, Wolfgang | Annotation and analysis of 10,000 expressed sequence tags from 3 mouse eye cDNA libraries | BACKGROUND: As a biomarker of cellular activities, the transcriptome of a specific tissue or cell type during development and disease is of great biomedical interest. We have generated and analyzed 10,000 expressed sequence tags (ESTs) from three mouse eye tissue cDNA libraries: embryonic day 15.5 (... | Cluster Analysis; DNA, Complementary; Gene Expression Profiling | 2003 |
108 |
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Larson, Scott A. | Strabismus surgery complications: prevention and management | Strabismus surgery is increasingly becoming a subspecialty domain, especially with cyclovertical muscles, restricted muscles, or reoperations. While is impossible to completely eliminate complications from strabimus surgery, it is possible to minimize their occurrence and significance by proper prev... | Malignant hyperthermia; Overcorrection; Strabismus; Surgery; Undercorrection | 2003 |
109 |
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Digre, Kathleen B. | Not so benign intracranial hypertension. | Despite many controversies, intracranial hypertension due to use of doxycycline does occur. Practitioners prescribing the tetracyclic antibiotics should be aware of the syndrome of increased intracranial pressure, and pay particular attention to the ocular fundus for papilloedema. Appropriate referr... | Venous Occusion; Venous Hypertension; Tetracycline, Doxycycline; Minocycline | 2003-03-22 |
110 |
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Olson, Randall J. | Efficacy and wound-temperature gradient of WhiteStar technology phacoemulsification through a 1.2 mm incision | PURPOSE: To evaluate the efficacy and wound-temperature gradients of WhiteStar micropulse technology using bimanual phacoemulsification without an irrigation sleeve through a 1.2 mm incision. SETTING: Island Eye Surgicenter, Carle Place, New York, USA. METHODS: Ten patients had bimanual phacoemulsif... | Endothelium, Corneal; Surgical Procedures; Lens Implantation; Wound Temperature gradient | 2003-06 |
111 |
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Olson, Randall J. | Clinical comparison of single-piece and three-piece truncated hydrophobic acrylic intraocular lenses | PURPOSE: To determine the clinical differences between three-piece (3P) and single-piece (SP) truncated hydrophobic acrylic intraocular lenses (IOL). DESIGN: Retrospective cohort clinical study. METHODS: The setting was an academic clinical practice. The patient population consisted of subjects with... | Lenses, Intraocular; Patient Satisfaction; Postoperative Complications; Prosthesis Design; Visual Acuity | 2003-10 |
112 |
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Frederick, Jeanne M.; Baehr, Wolfgang | Receptor for advanced glycation end products and age-related macular degeneration. | Advanced glycation end products (AGE) exacerbate disease progression through two general mechanisms: modifying molecules and forming nondegradable aggregates, thus impairing normal cellular/tissue functions, and altering cellular function directly through receptor-mediated activation. In the present... | Optic Atrophies, Hereditary; Apoptosis; Pigment Epithelium of Eye | 2004 |
113 |
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Zhang, Kang; Yang, Zhenglin; Jiang, Li | Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q | Familial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder of the retinal vascular system. Autosomal dominant FEVR is genetically heterogeneous, but its principal locus, EVR1, is on chromosome 11q13-q23. The gene encoding the Wnt receptor frizzled-4 (FZD4) was recently reported ... | Familial exudative vitreoretinopathy; FEVR; Inherited blinding disorders | 2004 |
114 |
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Baehr, Wolfgang | Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver | Lecithin-retinol acyltransferase (LRAT), an enzyme present mainly in the retinal pigmented epithelial cells and liver, converts all-trans-retinol into all-trans-retinyl esters. In the retinal pigmented epithelium, LRAT plays a key role in the retinoid cycle, a two-cell recycling system that replenis... | Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Microscopy, Fluorescence | 2004 |
115 |
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Baehr, Wolfgang | Novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration | PURPOSE: To identify pathogenic mutations in the guanylate cyclase-activating protein 1 (GCAP1) and GCAP2 genes and to characterize the biochemical effect of mutation on guanylate cyclase (GC) stimulation. METHODS: The GCAP1 and GCAP2 genes were screened by direct sequencing for mutations in 216 pat... | DNA Mutational Analysis; Mutation, Missense; Electroretinography | 2004 |
116 |
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Baehr, Wolfgang | Receptors for advanced glycation end products as progressive factors in age-related macular degeneration | Advanced glycation end products (AGE) exacerbate disease progression through two general mechanisms: modifying molecules and forming nondegradable aggregates, thus impairing normal cellular/tissue functions, and altering cellular function directly through receptor-mediated activation. In the prese... | Advanced glycation end products; AGE; receptor for AGE-mediated cellular activation; RAGE | 2004 |
117 |
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Zhang, Kang | Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy | Mutations in the frizzled-4 gene (FZD4) have recently been associated with autosomal dominant familial exudative vitreoretinopathy (FEVR) in families linking to the EVR1 locus on the long arm of chromosome 11. The purpose of this study was to screen FZD4 in a panel of 40 patients with FEVR to ident... | Frizzled-4 gene; FZD4; Mutation; autosomal dominant familial exudative autosomal dominant familial exudative; FEVR | 2004 |
118 |
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Normann, Richard A.; Shoham, Shy | Encoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglion | Recent advances in microelectrode array technology now permit a direct examination of the way populations of sensory neurons encode information about a limb's position in space. To address this issue, we recorded nerve impulses from about 100 single units simultaneously in the L6 and L7 dorsal root ... | Sensory; Encoding; Multielectrode; Dorsal Root Ganglion; Cutaneour; Muscle | 2004 |
119 |
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Normann, Richard A.; Branner, Almut | Long-term stimulation and recording with a penetrating microelectrode array in cat sciatic nerve | We studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions o... | Cats; Microelectrodes; Prosthesis Implantation; Sciatic Nerve | 2004 |
120 |
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Normann, Richard A.; Clark, Gregory A.; McDonnall, Daniel | Selective motor unit recruitment via intrafascicular multielectrode stimulation | Recruitment of force via independent asynchronous firing of large numbers of motor units produces the grace and endurance of physiological motion. We have investigated the possibility of reproducing this physiological recruitment strategy by determining the selectivity of access to large numbers of ... | Funtional Neuromuscular Stimulation; Microelectrode Array; Neuroprosthesis; Intrafascicular Multielectrode Stimulation; Cats | 2004 |
121 |
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Zhang, Kang | Novel mutation in the ELOVL4 gene causes autosomal dominant Stargardt-like macular dystrophy | PURPOSE. To conduct clinical and genetic studies in a European family with autosomal dominant Stargardt-like macular dystrophy (adSTGD-like MD) and to investigate the functional consequences of a novel ELOVL4 mutation | Macular dystrophy; ELOVL4 mutation; Genetics | 2004 |
122 |
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Frederick, Jeanne M.; Thulin, Craig; Bernstein, Paul S. | Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye | Uptake, metabolism, and stabilization of xanthophyll carotenoids in the retina are thought to be mediated by specific xanthophyll-binding proteins (XBPs). A membrane-associated XBP was purified from human macula using ion-exchange chromatography followed by gel-exclusion chromatography. Two-dimensio... | Circular Dichroism; Isoelectric Focusing; Macula Lutea; Xanthophylls | 2004 |
123 |
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Baehr, Wolfgang | Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye | Visual sensation in vertebrates is triggered when light strikes retinal photoreceptor cells causing photoisomerization of the rhodopsin chromophore 11-cis-retinal to all-trans-retinal. The regeneration of preillumination conditions of the photoreceptor cells requires formation of 11-cis-retinal in t... | Microscopy, Fluorescence; Visual Perception; Membrane Proteins | 2004 |
124 |
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Olson, Randall J. | Early experiences with microphaco | Microphaco is the separation of irrigation from aspiration that allows removal of cataracts through sub-2mm incisions. While proven intraocular lenses (IOLs) are not available at this time to take advantage of the small wounds, these wounds are advantageous from a separating irrigation standpoint w... | Microphaco; Cataracts; Irrigation; Wounds | 2004 |
125 |
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Zhang, Kang | Expression of wild type and mutant ELOVL4 in cell culture: subcellular localization and cell viability | PURPOSE: ELOVL4 is a member of the fatty acid elongase (ELO) family of genes. Mutations of this gene are responsible for autosomal dominant Stargardt-like macular degeneration. However, the specific role of ELOVL4 in photoreceptor cells and the mechanism by which mutations in ELOVL4 causes macular d... | Endoplasmic Reticulum; Green Fluorescent Proteins; Microscopy, Fluorescence | 2004 |