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CreatorTitleDescriptionSubjectDate
101 Randolph, CharlotteSynthesis of VLC-Pufas relating to macular degenerative diseasesVery Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs) are non-dietary fatty acids that are more than 24 carbons long and include more than one double bond. The specific compound we have focused on is 32:6 n-3: a 32-carbon molecule having 6 cis alkenes with the alkenes beginning at the omega 3 carb...2022
102 Steiner, WilliamRegulation of protein complexes during hedgehog signal transductionThe Hedgehog (Hh) pathway is an evolutionarily conserved signaling pathway essential in embryonic development and tissue homeostasis. Several cancers can form as a result of Hh pathway dysfunction. The G protein-coupled receptor (GPCR) Smoothened (SMO) is activated upon binding of the secreted Hh pr...2021
103 Watson, AndrePatterns of parasitism in a common Utah RodentMale-biased parasitism, where males are more commonly infected with and have higher parasite loads, is common across vertebrate taxa. Several factors could be driving this pattern. The immunocompetence handicap hypothesis suggests that higher testosterone levels in males suppress immune function whi...2022
104 Domagala, DrueSynthesis of protacs to inhibit toll-like receptorsThe immune system is the body's defense against pathogens. Since it has to be able to withstand the fast-evolving nature of microscopic invaders, the immune system has a variety of mechanisms to recognize and destroy them. One way that pathogens are recognized is through toll-like receptor (TLR) sig...2022
105 Excell, KaterinaThe role of amyloid precursor protein in a model of alzheimer's diseaseAlzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ...2022
106 Sperber, Alexander M.A novel approach to differentiating cardiac fibroblasts from induced pluripotent stem cellsHeart disease remains the leading cause of death in the United States, and such disease is caused by electrical, chemical, or biomechanical imbalances in the heart. The two most abundant cells comprising the heart that are responsible for these functions are cardiomyocytes and cardiac fibroblasts. I...2022
107 Spurlock, Ella K.Exploration of the 2-dimensional π-d conjugated coordination polymer Cu-benzenehexathoilCoordination polymers (CPs) are a type of atomically precise material that has long been an area of study for materials chemists. Recently, research has advanced with twodimensional conjugated CPs as detailed synthetic schemes are developed to create highly atomically ordered, large-area sheets. The...2022
108 Azadpour, ElmeraThe Effect of Inorganic VS Organic Fertilizer on an Urban Lawn in Salt Lake City, UtahWhile lawn management practices have altered the capacity for urban lawns to act as Nitrogen (N) sinks, there have been few studies of the effects of organic vs. inorganic fertilizer additions to urban lawns. We evaluated how foliar and soil N content and isotopic N composition (δ15N) varied as a r...2019
109 Fernandez, FlorenceEvaluation of environmental education in high school science courses across Salt Lake City, UtahWhile the effects of pollution become Incredibly more evident in the air of the Salt Lake Valley, many Utah high school students still lack the knowledge and information necessary to take preventative and immediate actions to protect their health and their environment. In this study, the reasons for...Environmental education -- Utah -- Salt Lake City; Science -- Study and teaching -- Utah -- Salt Lake City; Air -- Pollution -- Utah -- Salt Lake City2015-05
110 Mercer, MarianneEstablishing a System for Structure-Function analysis of the Novel Role that NUP153 Plays in Nuclear AssemblyIn mitosis, equal partitioning of DNA between daughter cells requires an integrated series of events. At the start of anaphase the chromatin separates and forms two chromatin discs. This chromatin is then targeted by nuclear membrane proteins and membrane to form the nuclear envelope. These membrane...2018
111 Fan, HuijunExamination of Y-Deterium isotope effects for the solvolysis of model isoprenoid compoundsModel isoprenoid compounds can undergo two distinct pathways, dissociative or associative nucleophilic substitution depending on the conditions used. The dissociative pathway consists of two steps, involving a carbocation intermediate where the formation of that carbocation is rate determining. The ...Isopentenoids; Solvolysis; Deuterium - Isotopes2012-05
112 Chure, Griffin DanielFLHE influences cellular morphology through control of flagellar assembly in escherichia coliThe bacterial flagellar motor is a complex nanomachine composed of thousands of individual protein subunits. One of these proteins, FlhE, has not been studied in depth and its function is not completely understood. The flhE gene is cotranscribed with flhB and flhA in the flhBAE flagellar operon. In ...Escherichia coli; Flagella (Microbiology)2013-05
113 Bowen, BradyFractal geometry of melt ponds: Modeling the fractal geometry of arctic melt ponds using the level sets of random surfacesDuring the late spring, most of the Arctic Ocean is covered by sea ice with a layer of snow on top. As the snow and sea ice begin to melt, water collects on the surface to form melt ponds. As melting progresses, sparse, disconnected ponds coalesce to form complex, self-similar structures which are c...Melt pond geometry2016-04
114 Blair, Coral DeanSnakes as a possible winter reservoir for Western equine encephalitis virusviruses; equine; snakes1964
115 Fackler, Anderson N.Identification of Kin-20 and UNC-119 Knockout suppressors associated with neuronal development and maintenance in C. elegansNeurons comprise the nervous system-the essential signaling and communication system for nearly all multicellular organisms. To coordinate cells across an entire organism, they must grow to be relatively long. Therefore, neurons extend axons from the cell body. Immature neurons extend growth cones a...2018
116 Ong, ElaineIdentifying Natural Genetic Modifiers of Apoptosis and Retinal DegenerationApoptosis, or cell death, is an integral part of many diseases such as neurodegeneration, retinal degeneration, and cancer, yet it is unclear how apoptosis varies among individuals in a population. Retinitis pigmentosa (RP) is a retinal degeneration disease characterized by phenotypic heterogeneity ...2018
117 Khuu, ScottIdentifying Retinoic Acid Dependent Mechanisms of Neural Crest Epithelial-Mesenchymal TransitionCancer metastasis is one of the distinguishing traits that make the disease difficult to treat. The steps of tumor invasion are similar to a process called epithelial to mesenchymal transition (EMT). Retinoic acid (RA) is shown to inhibit EMT and may cause an increased transcription of the gene, ski...2017
118 Wang, WenyiImaging in a homogeneous aluminum plate by using ultrasonic wavesThis project is about detecting and imaging damage (such as cracks) in a plate by using ultrasonic waves. The waves are generated by a source (an ultrasonic transducer) that is part of a robot that can move on the plate. The waves traveling in the plate are recorded at a receiver (another ultrasonic...Ultrasonic transducer - Mathematics; Kirchoff migration - Research2014-12
119 Black, AlyssaIdentifying hybrid male sterility genes in Drosophila PseudoobscuraSpeciation, the process of one species splitting into two separate species, often involves the evolution of hybrid sterility or hybrid inviability. These reproductive isolating barriers are caused by negative interactions between genes called hybrid incompatibilities. Identifying hybrid incompatibil...Infertility, Male -- Genetic aspects Drosophila pseudoobscura -- Genetics Male sterility genes2015-05
120 Johnson, KariAnne RencherIdentification of PASK substrates and/or interacting proteinsPAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live...Biology2012-05
121 Jones, Kathryn K.Hybrid Enzyme-Bimetallic Nanoparticle System for Tandem Oxidation CatalysisMetallic nanoparticles are commonly used as catalysts in industrial and academic settings. Recent observations that bimetallic nanoparticles can have enhanced activity over their monometallic counterparts has increased the interest in their synthesis and application to new catalytic systems. Combini...2020
122 Weaver, BradleyHypoxia and the mesenchymal transition in gliomaRecent advances in targeted therapy for cancer have had little influence on survival for patients diagnosed with Glioblastoma (GBM, WHO Grade IV tumors), and median survival time remains stagnant at 12-15 months post diagnosis. Genomic profiling of GBM indicates clear phenotypic subsets of these tum...Glioblastoma multiforme; Gliomas; Hypoxia; Mesenchymal transition2014-04
123 Au, AlexanderImpact of population density of left atrial remodeling in patients with atrial fibrillationAtrial fibrillation (AF), the most common cardiac arrhythmia and a leading cause of stroke, is characterized by structural changes, or remodeling, in tissues of the left atrium (LA). Late Gadolinium-Enhancement Magnetic Resonance Imaging (LGE-MRI) can noninvasively detect remodeling in the LA, allow...Atrial fibrillation Treatment2012-05
124 Beams, AlexanderImplications of antibiotic use for co-infections when a fitness trade-off for resistance is presentHow much does indiscriminate antibiotic use promote the spread of antibiotic-resistant infections in a population? Assuming a fitness trade-off for resistance exists, it is possible for an antibiotic-vulnerable strain to outlast a resistant type within an untreated host carrying both. That means pru...Drug resistance in microorganisms -- Mathematical models Co-infections2015
125 Walker, KortnieUnderstanding and treating diabetic retinopathyDiabetic retinopathy is a neurovascular disease of the retina and is the leading cause of blindness in the working-age population in the United States. Complications as a result of hyperglycemia and diabetes mellitus (DM) break down the blood-retina barrier (BRB) and retinal vasculature. Current tre...Diabetic retinopathy2015-05
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