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101 Schmidt, Meic H.; Apfelbaum, Ronald I.Cervical spinal metastasis: anterior reconstruction and stabilization techniques after tumor resectionObject. In a review of the literature, the authors provide an overview of various techniques that have evolved for reconstruction and stabilization after resection for metastatic disease in the subaxial cervical spine. Methods. Reconstruction and stabilization of the cervical spine after vertebral...Cervical spine reconstruction; Metastasis; Spine tumor; Corpectomy; Stabilization technique; Vertebral body2003
102 Couldwell, William T.Simple closure following transsphenoidal surgeryThe most common nonendocrine complication after transsphenoidal surgery is cerebrospinal fluid (CSF) leak. Many neurosurgeons have advocated the routine reconstruction of the floor of the sella turcica using autologous fat, muscle, fascia, and either cartilage or bone after transsphenoidal surgery t...2006
103 Couldwell, William T.Total intravenous anesthesia: advantages for intracranial surgeryAlthough volatile anesthetics have been widely accepted in anesthetic management for neurosurgery, they reduce vascular resistance, resulting in increased cerebral blood flow and increased intracranial pressure (ICP). In patients with elevated ICP who undergo craniotomy, the increase in ICP during s...Anesthesia; Inhalants; Intravenous; Propofol; Intracranial surgery2007
104 Couldwell, William T.; Chin, Steven S.Extranodal NK/T-cell lymphoma presenting as a pituitary massExtranodal NK/T-cell lymphomas are uncommon neoplasms that are highly aggressive and show a strong association with Epstein-Barr virus. They most commonly affect the nasal cavity and paranasal sinuses; manifestation as a primary pituitary tumor has never been described. The authors report a case of ...2007-09
105 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 7: intractable low-back pain without stenosis or spondylolisthesisStandards. Lumbar fusion is recommended as a treatment for carefully selected patients with disabling lowback pain due to one- or two-level degenerative disease without stenosis or spondylolisthesis. Guidelines. There is insufficient evidence available to support a treatment guideline. Options. An...Fusion; Lumbar spine; Degenerative disease; Low back pain2005
106 Couldwell, William T.Practicing neurosurgery in the United StatesCompared with other developed countries, the U.S. spends a high percentage of its gross domestic product on healthcare: 16 percent in 2005, up from 15 percent in 2004. This is far and away the greatest percentage of GDP spent on healthcare of any nation for which such data is collected. However,...2008-01-01
107 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 11: interbody techniques for lumbar fusionStandards. There is insufficient evidence to recommend a treatment standard. Guidelines. In the context of a single-level stand-alone ALIF or ALIF with posterior instrumentation, the addition of a PLF is not recommended as it increases operating room time and blood loss without influencing the like...Fusion; Lumbar spine; Degenerative disease; Lumbar fusion; Interbody techniques2005
108 Couldwell, William T.Radiographic features of tumefactive giant cavernous angiomasGiant cavernous angiomas (GCAs) are very rare, and imaging features of GCAs can be very different from those of typical cavernous angiomas (CAs), making them a diagnostic challenge. The purpose of the study was to evaluate the radiographic features of GCAs, with an emphasis on the differentiating fe...Cavernous angiomas; Cavernous malformations; Tumefactive2008
109 Couldwell, William T.Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifenPREVIOUS WORK HAS demonstrated the importance of the Protein Kinase C (PKC) signal transduction system in regulating the growth rate of malignant gliomas in vitro. Tamoxifen inhibits PKC in a minority of malignant gliomas within the micromolar concentration range in vitro, a property distinct from...Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Chemotherapy; Glioma1993
110 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 5: correlation between radiographic and functional outcomeStandards. There is insufficient evidence to recommend a treatment standard. Guidelines. There is insufficient evidence to recommend a treatment guideline. Options. It is recommended that when performing lumbar arthrodesis for degenerative lumbar disease, strategies to achieve successful radiogr...Lumbar fusion; Lumbar spine; Degenerative disease; Practice guidelines; Functional outcome; Radiographic outcome2005
111 Kestle, John R. W.Late rapid deterioration after endoscopic third ventriculostomy: additional cases and review of the literatureObject. Late rapid deterioration after endoscopic third ventriculostomy (ETV) is a rare complication. The authors previously reported three deaths from three centers. Three other deaths and a patient who experienced rapid deterioration have also been reported. Following the death at the University ...Endoscopic third ventriculostomy; ETV; Pediatric neurosurgery; Adverse outcome2006
112 Kestle, John R. W.Potentially useful outcome measures for clinical research in pediatric neurosurgeryThe choice of outcome (or outcomes) and their measurement are critical for a sound clinical trial. Surgeons have traditionally measured simple outcomes such as death, duration of survival, or tumor recurrence but have recently developed more sophisticated measures of the effect of an intervention. M...Pediatric neurosurgery2005
113 Schmidt, Meic H.Lumbosacral ependymomas: a review of the management of intradural and extradural tumorsObject. The goal of this study was to review the management of intra- and extradural ependymomas. Spinal ependymomas most commonly occur as intramedullary tumors throughout the spinal axis. In the lumbosacral region, ependymomas are most commonly associated with the conus medullaris and cauda equina...Intradural ependymoma; Extradural ependymoma; Lumbosacral lesion2003
114 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 3: assessment of economic outcomeStandards. There is insufficient evidence to recommend a standard for assessment of economic outcome following lumbar fusion for degenerative disease. Guidelines. There is insufficient evidence to recommend a guideline for assessment of economic outcome following lumbar fusion for degenerative dis...Lumbar fusion; Lumbar spine; Degenerative disease; Practice guidelines; Treatment outcome; Economic outcome2005
115 Kestle, John R. W.Multicenter prospective cohort study of the Strata valve for the management of hydrocephalus in pediatric patientsObject. Previous reports suggest that adjustable valves may improve the survival of cerebrospinal fluid shunts or relieve shunt-related symptoms. To evaluate these claims, the authors conducted a prospective multicenter cohort study of children who underwent placement of Strata valves. Methods. Pat...Ventriculoperitoneal shunt; Strata valve; Adjustable valves; Pediatric neurosurgery2005
116 Couldwell, William T.Porous polyethylene implant for cranioplasty and skull base reconstructionObject. Cranial reconstruction after skull base surgery is important for restoration of function and cosmesis. The authors describe their experience with the Medpor porous polyethylene implant for cosmetic cranioplasty and reconstruction after skull base surgery. Methods. Medpor, a biocompatible i...2004
117 Couldwell, William T.Rathke cleft cyst intracystic nodule: a characteristic magnetic resonance imaging findingObject. The fluid content of Rathke cleft cysts (RCCs) displays variable appearances on magnetic resonance (MR) images and can appear indistinguishable from other intrasellar or suprasellar cystic lesions. Intracystic nodules associated with individual RCCs have been noted, but to date their signifi...2005
118 Couldwell, William T.Transsphenoidal microsurgical treatment of Cushing disease: postoperative assessment of surgical efficacy by application of an overnight low-dose dexamethasone suppression testObject. Transsphenoidal adenomectomy with resection of a defined pituitary adenoma has been the treatment of choice for CD for the last 30 years. Surgical resection, however, may not always result in long-term remission of CD. This is particularly important in light of the high risk of morbidity and...2003-01-01
119 Couldwell, William T.Predictive value of serum prolactin levels measured immediately after transsphenoidal surgeryObject. Prolactin-secreting pituitary adenomas may be managed by surgery, medication, radiotherapy, or observation. The authors reviewed a consecutive series of patients who were followed for at least 5 years after surgery to assess the prognostic significance of preoperative factors (tumor size and...Prolactin; Transsphenoidal surgery; Pituitary adenoma; Prolactinoma; Transsphenoidal approach2002
120 Couldwell, William T.; Gillespie, David L.; Jensen, Randy L.Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysisOvercoming the metabolic restrictions of hypoxia may allow the progression of lower-grade tumors to glioblastoma multiforme. Our findings of up-regulation of HIF-1α and its downstream targets VEGF, GLUT-1, and CAIX in higher-grade gliomas support this hypothesis. We compared the gene expression pro...Glioblastoma multiforme; U-251; Hypoxia; Microarray analysis; Brain tumor; Depp; Astrocytoma2007
121 Couldwell, William T.Response to comment on: the combined transmastoid retro- and infralabyrinthine transjugular transcondylar transtubercular high cervical approach for resection of glomus jugulare tumorsWe appreciate the comments by Dr. Sanna regarding our article (1). We recognize Dr. Sanna has much experience with these tumors and that, as cranial base surgeons, we should work as a team of neurosurgeons, otologists, and occasionally, head and neck surgeons and plastic surgeons. We also agree tha...Jugular foramen tumor; Glomus jugulare tumors2007
122 Couldwell, William T.Multifocal inflammatory leukoencephalopathy associated with levamisole and 5-fluorouracil: case reportLEVAMISOLE AND 5-FLUOROURACIL have now become the standard chemotherapeutic regimen for patients with Stage 111 colon carcinoma. A case of multifocal inflammatory leukoencephalopathy secondary to levamisole alone or combination of levamisole and 5-fluorouracil is reported. Magnetic resonance imaging...Autopsy; Levamisole; Multifocal inflammatory leukoencephalopathy1994
123 Couldwell, William T.Comparison of radiosurgery and conventional surgery for the treatment of glomus jugulare tumorsObject. The optimal management of glomus jugulare tumors remains controversial. Available treatments were once associated with poor outcomes and significant complication rates. Advances in skull base surgery and the delivery of radiation therapy by stereotactic radiosurgery have improved the results...2004
124 Couldwell, William T.Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitroDirect measurement of protein kinase C (PKC) activity in vitro revealed a significant increase in the activity of the enzyme in all human malignant glioma lines examined and the rat C6 tumor in comparison with control nonneoplastic astrocyte and mixed glial cultures. The total and particulate PKC ac...Brain neoplasms; Flow cytometry; Glioma; Phorbol ester; Protein kinase C1991
125 Dailey, Andrew T.; Schmidt, Meic H.; Apfelbaum, Ronald I.Anterior fixation of odontoid fractures in an elderly populationObject. Fractures of the odontoid process are the most common fractures of the cervical spine in patients over the age of 70 years. The incidence of fracture nonunion in this population has been estimated to be 20-fold greater than that in patients under the age of 50 years if surgical stabilizatio...Odontoid fractures; Elderly population; Anterior fixation2010
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