Honors Theses Open Access
 
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76 Watkins, Ryan DavisSuppression of lymphangiogenesis using VEGF-C trapThe lymphatic system is responsible for controlling systemic fluid buildup. Lymphangiogenesis is a dynamic process involving sprouting, and maintaining new lymphatic vasculature. Vascular endothelial growth factor C (VEGF-C) is as a key growth factor that induces lymphangiogenesis by binding VEGF re...Lymphatics - Growth; Vascular endothelial growth factors - Antagonists; Lymphangiogenesis; VEGF-C trap2014-05
77 Domagala, DrueSynthesis of protacs to inhibit toll-like receptorsThe immune system is the body's defense against pathogens. Since it has to be able to withstand the fast-evolving nature of microscopic invaders, the immune system has a variety of mechanisms to recognize and destroy them. One way that pathogens are recognized is through toll-like receptor (TLR) sig...2022
78 Judd, David PaulTelomere proteins of Drosophila melanogaster: HipHop and MSK81DNA molecules encoding two proteins, HipHop and MSK81, were cloned into bacteria so as to make large amounts of these proteins that bind to telomeres of Drosophila (fruit fly) chromosomes. The goal was to determine whether known DNA binding motifs are present in HipHop and MSK81. Understanding how t...Biology2012-05
79 Roestenburg, JessicaTesting the Perceptual Salience of Spectral Content in Zebra Finch SongBirds actively adjust the resonance properties of the upper vocal tract during singing, which results in specific harmonic structures of song elements. To what degree upper vocal tract filtering is relevant for the perceptual salience of song is poorly understood. This research utilizes (1) a biolog...2018
80 Woodruff, DerekUncovering Synaptic Defects resulting from loss of the intellectual disability and autism-associated gene Kirrel3Neurodevelopmental disorders severely impact an individual's life. Surprisingly, the genetic and cellular cause of over half of intellectual disability cases and more than 80% of autism spectrum disorders remain undiscovered1,2. It is likely that mutations in molecules regulating synapse development...2017
81 Lee, ZacharyUsing Drosophila to investigate p53 life-or-death decisionsThe p53 tumor suppressor is a central regulator of cellular responses to DNA damage. When DNA damage cannot be repaired most cells undergo p53-dependent cell death. Thisp55-mediated apoptosis is important to eliminate cells with damaged genomes and provides an important block to the development of c...Biology2013-05
82 Checketts, CynthiaWhy white mice? improving biological literacy through animal historyThroughout the undergraduate experience, biology students are introduced to hundreds of experiments, theories, and principles, many of which are rooted in animal experimentation. However, in required and information-heavy biology courses, the erasure of animals from the scientific story-which repres...2021
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