Honors Theses Open Access
 
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76 Johnston, Jessica FaithFrom nanoscience to astrophysics: using high-resolution microscopy and spectroscopy of carbonaceous chondrites to understand planet formationIn the field of astrophysics, there currently exists an outstanding gap of knowledge in understanding planet formation dynamics. At the formation scale ranging from millimeters to meters, astrophysicists debate as to how solar nebulae form larger masses-planets and other kilometer-sized bodies-from ...Physics & Astronomy2012-05
77 Narasipura, Eshan AmruthFull synthesis of enzymatically cleavable linker between 929-designed ankyrin repeat protein and 17-dimethlyamino geldanamycinTargeted cancer therapeutics are an important and promising field of cancer research due to their ability to reduce the off target effects produced in other therapies such as chemotherapy. Antibody Drug Conjugates (ADC) are one such therapeutic that specifically target cancer cells through antibody-...2021
78 Capener, JacobG Protein-Coupled resecptor kinase 2 mediated phosphorylation for The Activation of SmoothenedThe Hedgehog (Hh) pathway is a cell signaling pathway that is involved in embryonic development and adult tissue maintenance in vertebrates. Improper functioning of this pathway can lead to developmental disorders and several forms of cancer. Despite the pathway's biological importance, the transduc...2020
79 Imig, JulieGalactic Evolution of Phosphorus and Sulfur Using Star ClustersThe chemical composition of a galaxy changes as it evolves, so understanding the evolutionary processes of individual elements can be powerful tools in unravelling the history of a galaxy. Phosphorus is considered one of the key building blocks of life, and sulfur is an alpha-element, a tracer of su...2017
80 Borrowman, WilliamGas exchange of co-occurring plant species of the Great Basin Desert in an irrigated common gardenThe majority of plants in the Great Basin ecosystem have adapted to cope with drought during summer. While general characteristics of these plants have been studied in non-managed environments it is important to investigate the physiology of these plants when additional water is supplied. In this ...Urban heat island -- Prevention; Desert plants -- Ecology -- Great Basin -- Research; Plant ecophysiology -- Research; Irrigation -- Environmental aspects; Red Butte Garden (Salt Lake City, Utah)2014-04
81 Loret, AmyGenetic Modifiers of Severity in Collagen VI-Related Muscular DystrophyCollagen VI-related muscular dystrophies (COL6-RD) display phenotypic heterogeneity that includes mild Bethlem myopathy (BM), intermediate (INT), and severe Ullrich congenital muscular dystrophy (UCMD) phenotypes. COL6-RD are characterized by mutations within the collagen VI genes (COL6A1, COL6A2, a...2019
82 Rahmati, KasraGenetically Modified Chemotaxis Signaling Protein Chey Binds to the Rotor Protein Flin to Control the Direction of Flagellar Rotation in Escherichia ColiBacterial chemotaxis is the directed movement of a bacterium in response to environmental chemical stimuli. Cells of E. coli, for example, swim by rotating their flagella and direct their movement by regulating reversals between counterclockwise (CCW) and clockwise (CW) rotation. The switch from CCW...2020
83 Acosta, LehiGenotype-dependent susceptibility to influenza and titer-virulence discordanceThe influenza a virus (IAV) is a major source of human mortality and both recent and anticipated pandemics make understanding this major human pathogen of paramount importance1,2. The use of mouse models allows us to experimentally manipulate critical variables to more fully understand the dynamics ...Influenza A virus - Research; Mice as laboratory animals - Research; Transmissibility; Virulence; Viral titers; Erythropoeintin2016-05
84 Lan, Yung-ChiHYPO-osmolarity and glucose starvation localizes slm1 to mitochondria- A novel stress response pathwaySynthetic Lethal with Mss4 1 (Slm1) is a key protein found in the crossroad of the Membrane Compartment of Can1 (MCC) and the Membrane Compartment of TORC2 (MCT). The two compartments on the plasma membrane of budding yeast (Saccharomyces cerevisiae) are responsible for APC transporter regulation an...2022
85 Fischer, PaulHigh-Performance Computing Performance Metric AnalysisAt present, a signi#12;cant amount of ongoing scienti#12;c research relies on computational models. High-performance computing (HPC) resources are often required to obtain results in a reasonable amount of time. However, as physical and practical limitations constrain the performance progression of ...2019
86 Kutschke, MichaelHip joint center differences between dual fluoroscopy, functional hip, and coda - establishing a reference standardMeasurements of joint angles, moments, and forces may be highly sensitive to positional changes in the center of a joint. Due to its deep location, the human hip joint center (HJC) can be difficult to determine. Previous studies have defined the HJC relative to external landmarks using infrared moti...Hip joint; Hip joint center2015-05
87 Jones, Kathryn K.Hybrid Enzyme-Bimetallic Nanoparticle System for Tandem Oxidation CatalysisMetallic nanoparticles are commonly used as catalysts in industrial and academic settings. Recent observations that bimetallic nanoparticles can have enhanced activity over their monometallic counterparts has increased the interest in their synthesis and application to new catalytic systems. Combini...2020
88 Weaver, BradleyHypoxia and the mesenchymal transition in gliomaRecent advances in targeted therapy for cancer have had little influence on survival for patients diagnosed with Glioblastoma (GBM, WHO Grade IV tumors), and median survival time remains stagnant at 12-15 months post diagnosis. Genomic profiling of GBM indicates clear phenotypic subsets of these tum...Glioblastoma multiforme; Gliomas; Hypoxia; Mesenchymal transition2014-04
89 Fackler, Anderson N.Identification of Kin-20 and UNC-119 Knockout suppressors associated with neuronal development and maintenance in C. elegansNeurons comprise the nervous system-the essential signaling and communication system for nearly all multicellular organisms. To coordinate cells across an entire organism, they must grow to be relatively long. Therefore, neurons extend axons from the cell body. Immature neurons extend growth cones a...2018
90 Johnson, KariAnne RencherIdentification of PASK substrates and/or interacting proteinsPAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live...Biology2012-05
91 Identification of potential causes for increased central line associated bloostream infection rates in the University of Utah NICUThe University of Utah Newborn Intensive Care Unit (UUNICU) has seen a recent increase in rate of Central Line Associated Bloodstream Infection (CLABSI) after an extended period of 965 days with no CLABSI's. Unfortunately, in the last three years, infection rate has been on average 2.6 CLABSI per ye...2023
92 Ong, ElaineIdentifying Natural Genetic Modifiers of Apoptosis and Retinal DegenerationApoptosis, or cell death, is an integral part of many diseases such as neurodegeneration, retinal degeneration, and cancer, yet it is unclear how apoptosis varies among individuals in a population. Retinitis pigmentosa (RP) is a retinal degeneration disease characterized by phenotypic heterogeneity ...2018
93 Khuu, ScottIdentifying Retinoic Acid Dependent Mechanisms of Neural Crest Epithelial-Mesenchymal TransitionCancer metastasis is one of the distinguishing traits that make the disease difficult to treat. The steps of tumor invasion are similar to a process called epithelial to mesenchymal transition (EMT). Retinoic acid (RA) is shown to inhibit EMT and may cause an increased transcription of the gene, ski...2017
94 Black, AlyssaIdentifying hybrid male sterility genes in Drosophila PseudoobscuraSpeciation, the process of one species splitting into two separate species, often involves the evolution of hybrid sterility or hybrid inviability. These reproductive isolating barriers are caused by negative interactions between genes called hybrid incompatibilities. Identifying hybrid incompatibil...Infertility, Male -- Genetic aspects Drosophila pseudoobscura -- Genetics Male sterility genes2015-05
95 Wang, WenyiImaging in a homogeneous aluminum plate by using ultrasonic wavesThis project is about detecting and imaging damage (such as cracks) in a plate by using ultrasonic waves. The waves are generated by a source (an ultrasonic transducer) that is part of a robot that can move on the plate. The waves traveling in the plate are recorded at a receiver (another ultrasonic...Ultrasonic transducer - Mathematics; Kirchoff migration - Research2014-12
96 Au, AlexanderImpact of population density of left atrial remodeling in patients with atrial fibrillationAtrial fibrillation (AF), the most common cardiac arrhythmia and a leading cause of stroke, is characterized by structural changes, or remodeling, in tissues of the left atrium (LA). Late Gadolinium-Enhancement Magnetic Resonance Imaging (LGE-MRI) can noninvasively detect remodeling in the LA, allow...Atrial fibrillation Treatment2012-05
97 Beams, AlexanderImplications of antibiotic use for co-infections when a fitness trade-off for resistance is presentHow much does indiscriminate antibiotic use promote the spread of antibiotic-resistant infections in a population? Assuming a fitness trade-off for resistance exists, it is possible for an antibiotic-vulnerable strain to outlast a resistant type within an untreated host carrying both. That means pru...Drug resistance in microorganisms -- Mathematical models Co-infections2015
98 Owen, Cameron J.Infrared Multiple Photon Dissociation Spectroscopy and Guided Ion Beam Tandem Mass Spectrometry: Experimental and Theoretical investigations of Transition Metal and Lanthandie CationsEmployment of Free Electron Lasers (FELs) and a Guided Ion Beam Tandem Mass Spectrometer (GIBMS) has allowed for the spectroscopic and spectrometric investigations of a variety of ionic complexes, respectively. The data presented in Chapters 2 and 3 of this thesis were obtained using two FELs locate...2019
99 Allam, JeremyLow-energy satellite transfer from Earth to MarsA new type of satellite transfer that uses half the amount of fuel as conventional transfers has been discovered. This transfer, called a low-energy transfer, proved to work in 1991 when a Japanese satellite successfully went in orbit around the moon using this technique. Since then, more research h...Space vehicles -- Dynamics -- Mathematics Space flight to Mars -- Mathematics2015-04
100 Wallace, Joshua J.Lyman-alpha emission as a probe of galaxy environmentsAs a result of resonant scatterings off hydrogen atoms, Lya emission from star-forming galaxies provides a potential probe of the neutral gas environment around them. In order to determine the utility of Lya emission as a probe of gas environments we study the effects of environmental anisotropy on ...Galaxies - Spectra2014-05
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