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CreatorTitleDescriptionSubjectDate
76 Christensen, Douglas A.; Furse, Cynthia M.Problem and treatment of DC offsets in FDTD simulationsThis paper discusses the causes of and some solutions to the commonly observed problem of dc field offsets in finite-difference time-domain (FDTD) simulations. DC electric and magnetic field offsets are shown to be valid calculated responses of the modeled systems, resulting from interaction betwee...Finite-difference time-domain method; Direct current offsets; Waveforms2000-08
77 Christensen, Douglas A.Using the cardiovascular system to illustrate fundamental laws and principles in a freshman courseOur Fundamentals of Bioengineering I course is organized around key physical and engineering laws and principles. A semester-long Major Project is assigned which integrates many of these principles by modeling the human systemic cardiovascular system, using both Matlab computer analysis and assembly...Matlab2002
78 Horch, Kenneth W.; Christensen, Douglas A.Accelerated 4-year bachelors/masters degree program in biomedical engineeringIn response to the need for providing advanced engineering education in a shorter time period than is currently possible by traditional curricula, we have created an Accelerated Dual Degree program in biomedical engineering. The purpose of this pilot program is to attract the brightest students, g...Accelerated dual-degree program2002
79 Horch, Kenneth W.; Christensen, Douglas A.Accelerated 4-year bachelors/masters degree program in biomedical engineeringIn response to the need for providing advanced engineering education in a shorter time period than is currently possible by traditional curricula, we have created an Accelerated Dual Degree program in biomedical engineering. The purpose of this pilot program is to attract the brightest students, g...Accelerated; Dual-degrees; Education2002
80 Angelucci, Alessandra; Lund, Jennifer S.Circuits for local and global signal integration in primary visual cortexContrast-dependent changes in spatial summation and contextual modulation of primary visual cortex (V1) neuron responses to stimulation of their receptive field reveal long-distance integration of visual signals within V1, well beyond the classical receptive field (cRF) of single neurons. To identif...Primary Visual Cortex; Extrastriate Cortex; Feed-back Connections; Lateral Connections; SUrround Modulation; Macaque2002-10-01
81 Varner, Michael W.; Clark, Edward B.; Fernando, Kumari L.; Mathews, V. JohnRobust estimation of fetal heart rate variability using Doppler ultrasound.This paper presents a new measure of heart rate variability (HRV) that can be estimated using Doppler ultrasound techniques and is robust to variations in the angle of incidence of the ultrasound beam and the measurement noise. This measure employs the multiple signal characterization (MUSIC) algori...Prenatal Ultrasonography; Fetal Heart Rate; Blood Flow Velocity; Algorithms2003-08
82 Horch, Kenneth W.; Lawrence, Steve M.; Dhillon, Gurpreet S.Acute peripheral nerve recording characteristics of polymer-based longitudinal intrafascicular electrodesWe examined the recording characteristics of two different types of polymer-based longitudinal intrafascicular electrodes (LIFEs) in peripheral nerve: single-stranded (s-polyLIFEs) and multistranded (m-polyLIFEs). Recordings were also made from Pt-Ir wire-based electrodes (PtIrLIFEs) as a control. T...Sciatic Nerve; Intrafascicular Electrodes, Peripheral Nerve Recording2004
83 Horch, Kenneth W.Ontogeny of diving and feeding behavior in juvenile seaturtles: Leatherback Seaturtles (Dermochelys coriacea L) and Green Seaturtles (Chelonia mydas L) in the Florida CurrentWe compared activity, diving behavior and response to prey by Dermochelys coriacea and Chelonia mydas during their first 8-10 weeks of development.We reared juveniles in the laboratory and, at two-week intervals, released them in the ocean for a brief trial. Each turtle towed a device used to measur...Hatchlings; Posthatchling; Habitats2004
84 Normann, Richard A.; Shoham, ShyEncoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglionRecent advances in microelectrode array technology now permit a direct examination of the way populations of sensory neurons encode information about a limb's position in space. To address this issue, we recorded nerve impulses from about 100 single units simultaneously in the L6 and L7 dorsal root ...Sensory; Encoding; Multielectrode; Dorsal Root Ganglion; Cutaneour; Muscle2004
85 Normann, Richard A.; Clark, Gregory A.; McDonnall, DanielSelective motor unit recruitment via intrafascicular multielectrode stimulationRecruitment of force via independent asynchronous firing of large numbers of motor units produces the grace and endurance of physiological motion. We have investigated the possibility of reproducing this physiological recruitment strategy by determining the selectivity of access to large numbers of ...Funtional Neuromuscular Stimulation; Microelectrode Array; Neuroprosthesis; Intrafascicular Multielectrode Stimulation; Cats2004
86 Gesteland, Raymond F.; Atkins, John F.; Baranov, Pavel V.P-site tRNA is a crucial initiator of ribosomal frameshiftingThe expression of some genes requires a high proportion of ribosomes to shift at a specific site into one of the two alternative frames. This utilized frameshifting provides a unique tool for studying reading frame control. Peptidyl-tRNA slippage has been invoked to explain many cases of programmed ...Translation; Recoding; Kinetic Model; Frameshifting; Ribosome2004
87 Baehr, Wolfgang; Prestwich, Glenn D.Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding proteinBovine PDEdelta was originally copurified with rod cGMP phosphodiesterase (PDE) and shown to interact with prenylated, carboxymethylated C-terminal Cys residues. Other studies showed that PDEdelta can interact with several small GTPases including Rab13, Ras, Rap, and Rho6, all of which are prenylate...Fluorescence Resonance Energy Transfer; GTP Phosphohydrolases; Immunohistochemistry2004
88 Christensen, Douglas A.Bringing an integrative modeling experience to a freshman biomedical engineering courseAs an integrating lab experience in our Fundamentals of Bioengineering freshman course, we have included a Major Project that ties together many of the principles of biomechanics and bioelectricity covered in the lecture. It uses the human systemic cardiovascular system as a model. During the first...Matlab2004
89 Christensen, Douglas A.; Horch, Kenneth W.Experience with the first three years of an accelerated dual-degree program in biomedical engineeringOur Department of Bioengineering has instituted a pilot program aimed at helping a select group of highly qualified students obtain both bachelor's and master's degrees in an accelerated timeframe-approximately four years from the beginning of their university studies. A key element of this progra...Accelerated; Dual-degrees; Education2004
90 Christensen, Douglas A.; Horch, Kenneth W.Accelerated dual-degree BS/MS program - experience with the first three yearsWe have initiated a pilot program that accelerates the studies of a small group of highly qualified students early in their college careers and allows them to earn both a bachelor's degree and a master's degree in about four years after starting college. It does this by introducing them early to res...Accelerated dual-degree program2004
91 Normann, Richard A.Functional reorganization of primary visual cortex induced by electrical stimulation in the cat.Compared to the high degree of plasticity observed in a juvenile, mature sensory cortices have long been held to be immutable but, recently, researchers have suggested some plasticity persists in the mature cortex. Cortical reorganization has particular saliency to the development of a cortically ba...Cat; Electrophysiology; Phosphene; Plasticity; Receptive Field; Striate Cortex2005
92 Horch, Kenneth W.; Dhillon, Gurpreet S.Direct neural sensory feedback and control of a prosthetic armEvidence indicates that user acceptance of modern artificial limbs by amputees would be significantly enhanced by a system that provides appropriate, graded, distally referred sensations of touch and joint movement, and that the functionality of limb prostheses would be improved by a more natural co...Peripheral Nerve Implant; Prosthetic Limb Control; Sensory Feedback2005-12
93 Hansen, Mark S.; Healy, Lindsey J.; Johnson, Christopher R.; Capecchi, Mario R.; Keller, Charles; Jones, Greg M.Virtual histology of transgenic mouse embryos for high-throughput phenotyping.A bold new effort to disrupt every gene in the mouse genome necessitates systematic, interdisciplinary approaches to analyzing patterning defects in the mouse embryo. We present a novel, rapid, and inexpensive method for obtaining high-resolution virtual histology for phenotypic assessment of mouse ...Forkhead Transcription Factors; Paired Box Transcription Factors2006
94 Christensen, Douglas A.; Herron, James N.Rapid single nucleotide polymorphism detection for personalized medicine applications using planar waveguide fluorescence sensorsPersonalized medicine is an emerging field in which clinical diagnostics information about a patient's genotype or phenotype is used to optimize his/her pharmacotherapy. This article evaluates whether planar waveguide fluorescent sensors are suitable for determining such information from patient tes...Personalized medicine; Planar waveguides; Fluorescence sensors; Evanescent excitation; Fluorescence; Hybridization; Molecular diagnostics; Peptide nucleic acid; Point of care; Single base extension; Single nucleotide polymorphism2006
95 Christensen, Douglas A.Ultrasound-enhanced localized chemotherapy of drug-sensitive and multidrug resistant tumorsA new modality of targeted tumor chemotherapy is based on the drug encapsulation in polymeric nanoparticles followed by a localized release at the tumor site triggered by focused ultrasound. Effect of 1 MHz and 3 MHz unfocused ultrasound applied locally to the tumor on the Doxorubicin (DOX) biodistr...Ultrasound-enhanced chemotherapy; Drug-resistant tumors; Biodistribution; Tumor sonication2006
96 Horch, Kenneth W.Towards a neuroprosthetic armEvidence indicates that user acceptance of modern artificial limbs by amputees would be significantly enhanced by a system that provides appropriate, graded, distally referred sensations of touch and joint movement, and that the functionality of limb prostheses would be improved by a more natural co...Neuroprosthetic arm; Peripheral nerve; Neuroprosthetics; Amputee2006
97 Horch, Kenneth W.Differential activation of nerve fibers with magnetic stimulation in humansEarlier observations in our lab had indicated that large, time-varying magnetic fields could elicit action potentials that travel in only one direction in at least some of the myelinated axons in peripheral nerves. The objective of this study was to collect quantitative evidence for magnetically in...Magnetic stimulation; Peripheral nerve; Electromyographic potential; Somatosensory potential2006
98 Gesteland, Raymond F.; Atkins, John F.Evolutionary specialization of recoding: frameshifting in the expression of S. cerevisiae antizyme mRNA is via an atypical antizyme shift site but is still +1An autoregulatory translational shift to the +1 frame is required for the expression of ornithine decarboxylase antizyme from fungi to mammals. In most eukaryotes, including all vertebrates and a majority of the studied fungi/yeast, the site on antizyme mRNA where the shift occurs is UCC-UGA. The me...Antizyme; ODC; Polyamines; Frameshifting2006
99 Horch, Kenneth W.Intraspinal microstimulation using cylindrical multielectrodesA cylindrical multielectrode system specifically designed for intraspinal microstimulation was mechanically and electrically evaluated in the ventral horn of the feline lumbo-sacral spinal cord. Electrode insertions proved to be straight as evaluated from radiographs. Impedances were measured in s...Cylindrical multielectrode; Microstimulation; Neural prosthesis; Current distance constants; Electrode array; Spinal cord stimulation2006-02
100 Horch, Kenneth W.Microfabricated cylindrical multielectrodes for neural stimulationThe effects of spinal cord injuries are likely to be ameliorated with the help of functional electrical stimulation of the spinal cord, a technique that may benefit from a new style of electrode: the cylindrical multielectrode. This paper describes the specifications for, fabrication techniques for...Cylindrical multielectrode; Depth electrodes; Impedance testing; Microelectromechanical systems (MEMS); Microstimulation; Impedance testing; Neural prosthesis2006-02
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