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Creator | Title | Description | Subject | Date |
76 |
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Baehr, Wolfgang; Prestwich, Glenn D. | Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein | Bovine PDEdelta was originally copurified with rod cGMP phosphodiesterase (PDE) and shown to interact with prenylated, carboxymethylated C-terminal Cys residues. Other studies showed that PDEdelta can interact with several small GTPases including Rab13, Ras, Rap, and Rho6, all of which are prenylate... | Fluorescence Resonance Energy Transfer; GTP Phosphohydrolases; Immunohistochemistry | 2004 |
77 |
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Horch, Kenneth W.; Christensen, Douglas A. | Accelerated 4-year bachelors/masters degree program in biomedical engineering | In response to the need for providing advanced engineering education in a shorter time period than is currently possible by traditional curricula, we have created an Accelerated Dual Degree program in biomedical engineering. The purpose of this pilot program is to attract the brightest students, g... | Accelerated; Dual-degrees; Education | 2002 |
78 |
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Christensen, Douglas A. | Bringing an integrative modeling experience to a freshman biomedical engineering course | As an integrating lab experience in our Fundamentals of Bioengineering freshman course, we have included a Major Project that ties together many of the principles of biomechanics and bioelectricity covered in the lecture. It uses the human systemic cardiovascular system as a model. During the first... | Matlab | 2004 |
79 |
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Christensen, Douglas A. | Finite-difference time-domain modeling and experimental characterization of planar waveguide fluorescence sensors | The finite-difference time-domain method (FDTD) is a powerful numerical technique for solving Maxwell's equations in a discretized space and time grid. Its applications have up to now been in the analysis of electrically large structures in the microwave domain, and the scope of investigations has b... | Finite-difference time-domain method; Planar waveguide | 1992 |
80 |
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Varner, Michael W.; Clark, Edward B.; Fernando, Kumari L.; Mathews, V. John | Robust estimation of fetal heart rate variability using Doppler ultrasound. | This paper presents a new measure of heart rate variability (HRV) that can be estimated using Doppler ultrasound techniques and is robust to variations in the angle of incidence of the ultrasound beam and the measurement noise. This measure employs the multiple signal characterization (MUSIC) algori... | Prenatal Ultrasonography; Fetal Heart Rate; Blood Flow Velocity; Algorithms | 2003-08 |
81 |
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Gesteland, Raymond F.; Krapcho, Karen J.; Talbot, Phil; Thulin, Craig | Crystallization of the MS2 translational repressor alone and complexed to bromouridine | The coat protein from the MS2 bacteriophage plays a dual role by encapsidating viral RNA and also by binding RNA as a translational repressor. In order to study the isolated dimer in a conformation not influenced by capsid interactions, a mutant molecule was crystallized that is defective in capsid ... | Crystallization; RNA Bacteriophage; RNA Hairpin; Translational Repressor | 1995 |
82 |
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Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Neural signal for the intensity of a tactile stimulus | The effect of indenting the skin at different rates on the perceived intensity of the stimulus was studied by indenting the skin of the fingertip with two triangular waveforms, given as a pair. The subjects were asked to judge which member of the pair was more intense. Perceived intensity was foun... | Skin; Indentation; Nerve impulses | 1984 |
83 |
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Gesteland, Raymond F. | Characterization of lysozyme messenger and lysozyme synthesized in vitro | In vitro systems for protein systhesis have been in wide use for about 10 years. In most of the early work protein synthesis was measured by following the incorporation of radioactive amino acids into acid precipitable material. This test cannot distinguish between the synthesis of complete, activ... | Lysozyme Messenger; Lysozyme Synthesized; Protein Synthesis | 1969 |
84 |
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Horch, Kenneth W. | Perspectives on new electrode technology for stimulating peripheral nerves with implantable motor prostheses | Abstract-The limits of present electrode technology are being reached in current motor prostheses for restoring functional movement in paralyzed people. Improved devices require electrodes and stimulation methods that will activate muscles selectively and independently with less implanted hardwa... | Paralysis; Prostheses; Electrodes | 1995 |
85 |
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Gesteland, Raymond F.; Atkins, John F.; Wills, Norma M. | rRNA-mRNA base pairing stimulates a programmed -1 ribosomal frameshift | Base pairing between the 3' end of 16S rRNA and mRNA is shown to be important for the programmed -1 frameshifting utilized in decoding the Escherichia coli dnaX gene. This pairing is the same as the Shine-Dalgarno pairing used by prokaryotic ribosomes in selection of translation initiators, but for ... | Frameshifting; Escherichia coli; Binding Sites; Base Composition | 1994 |
86 |
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Horch, Kenneth W. | Selective stimulation of peripheral nerve fibers using dual intrafascicular electrodes | We have studied activation of newe fibers by pairs of Pt-Ir wire electrodes implanted within single fascicles of the nerve innervating the gastrocnemius muscle in cats. The purpose of this study was to determine if these intrafascicular electrodes can activate nerve fibers in different fascicles... | Functional electrical stimulation; Intrafascicular stimulation; Silicon electrode array | 1993 |
87 |
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Gesteland, Raymond F. | Simian virus 40-specific polypeptides in Ad2+ND4- infected cells | A comparison of the proteins synthesized in human cells at late times after infection with adenovirus (Ad2) and with the adeno-simian virus 40 (SV40) hybrid viruses revealed polypeptides of 30,000 and 92,000 molecular weight specific for the hybrid viruses Ad2+ND1 and Ad2+ND4, respectively. Cell-fre... | Molecular Weight; Peptide Biosynthesis; RNA, Messenger; Viral Proteins | 1976 |
88 |
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Christensen, Douglas A.; Herron, James N. | Optical immunoassay systems based upon evanescent wave interactions | Immunoassays based upon evanescent wave interactions are finding increased biosensing application. In these devices, the evanescent tail associated with total internal reflection of an incident beam at the substrate/solution interface provides sensitivity for surface-bound proteins over bulk molec... | Diagnostics; Evanescence; Planar waveguides; Human chorionic gonadotropin (hCG) | 1996 |
89 |
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Christensen, Douglas A. | Interface of forest and agriculture in nonpoint pollution control | Management practices of agriculture, including conservation and tillage options, recently have received a great deal of attention with respect to their impact upon the environment. Research efforts have focused both on the direct impacts of reduced on-site productivity resulting from the erosion of ... | Suspended sediment; Channel erosion; Silviculture | 1983 |
90 |
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Horch, Kenneth W. | Tracking changes in action potential shapes in chronic multi-unit intrafascicular recordings using neural network pattern recognition techniques | A novel scheme is proposed to train an Artificial Neural Network (A") classifier, on a repeated basis, in order to track temporal changes in the shapes of the action potentials recorded through chronically implanted intrafascicular electrodes. This scheme uses classification results of the ANN Clas... | Intrafascicular electrodes; Artificial neural network | 1994 |
91 |
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Christensen, Douglas A. | Effects of increased energy prices on U.S. agriculture: an econometric approach | Although the contents of this manuscript remain the responsibility of the authors, we wish to thanks a group of reviewers for the time and conscientious effort they put forth to solidify this final draft. Andrew Morton, Brian Holding, Wesley Buchele, and Arnold Paulsen deserve much credit for their ... | Energy prices | 1981 |
92 |
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Horch, Kenneth W. | Control of ankle position using neural feedback | This paper describes a closed loop control system that uses afferent neural activity from muscle spindle fibers as feedback for controlling ankle position. The gastrocnemius muscle was stimulated through a dual channel intrafascicular electrode implanted in a fascicle of the tibial nerve. Dual cha... | Neuromuscular stimulation; Peripheral nerve; Joint angle | 1994 |
93 |
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Gesteland, Raymond F.; Atkins, John F. | Evolutionary specialization of recoding: frameshifting in the expression of S. cerevisiae antizyme mRNA is via an atypical antizyme shift site but is still +1 | An autoregulatory translational shift to the +1 frame is required for the expression of ornithine decarboxylase antizyme from fungi to mammals. In most eukaryotes, including all vertebrates and a majority of the studied fungi/yeast, the site on antizyme mRNA where the shift occurs is UCC-UGA. The me... | Antizyme; ODC; Polyamines; Frameshifting | 2006 |
94 |
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Normann, Richard A. | Effects of GABA and related drugs on horizontal cells in the isolated turtle retina | The role of GABA in the outer plexiform layer of the turtle retina has been examined by intracellular recordings from L- and C-type horizontal cells in the isolated retina preparation. GABA (1-5 mM) slightly depolarized the L-type horizontal cells, reduced the amplitude of their photoresponses, and ... | Retina; Horizontal Cells; Synapse; Negative Feedback; GABA; Turtle | 1990 |
95 |
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Gesteland, Raymond F. | Pattern of protein synthesis in monkey cells infected by simian virus 40 | After infection of several permanent monkey cell lines by simian virus 40 (SV40), four additional protein bands can be detected by simple sodium dodecyl sulfate-polyacrylamide gel electrophoresis of whole-cell extracts. These bands appear only after the onset of viral deoxyribonucleic acid (DNA) syn... | Monkeys; Simian virus 40; Peptides; DNA, Viral/biosynthesis | 1972 |
96 |
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Horch, Kenneth W. | Action potential classification with dual channel intrafascicular electrodes | Using recordings of peripheral nerve activity made with carbon fiber intrafascicular electrodes, we compared the performance of three different recording techniques (single channel, differential, and dual channel) and four different unit classification methods (linear discriminant analysis, temp... | Carbon fiber intrafascicular electrodes; Dual channel recording | 1994 |
97 |
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Christensen, Douglas A.; Horch, Kenneth W. | Experience with the first three years of an accelerated dual-degree program in biomedical engineering | Our Department of Bioengineering has instituted a pilot program aimed at helping a select group of highly qualified students obtain both bachelor's and master's degrees in an accelerated timeframe-approximately four years from the beginning of their university studies. A key element of this progra... | Accelerated; Dual-degrees; Education | 2004 |
98 |
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Horch, Kenneth W.; Tuckett, Robert P.; Burgess, Paul Richard | Neural signal for skin indentation depth. II. Steady indentations | The glabrous skin of the monkey's hand was stimulated with a waveform that indented the skin at a rate of 0.4 mm/set, held the skin steadily or nearly steadily indented for 12 set or longer, and then retracted back to the starting position. Recordings were made of activity in single afferent fibe... | Skin; Indentation; Nerve impulses | 1983 |
99 |
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Christensen, Douglas A. | Multiple sensor optical thermometry system for application in clinical hyperthermia | The thermometry system described is based upon the temperature dependence of the band edge absorption of infrared light in GaAs crystal. The design of the thermometry was completed, and the system was subjected to an extensive evaluation, including testing with tissue phantoms and microwave applic... | Thermometry; Hyperthermia applicator; Phantom tests | 1984-01 |
100 |
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Normann, Richard A.; Horch, Kenneth W.; Cha, Kichul | Mobility performance with a pixelized vision system | A visual prosthesis, based on electrical stimulation of the visual cortex, has been suggested as a means for partially restoring functional vision in the blind. The prosthesis would create a pixelized visual sense consisting of punctate spots of light (phosphenes). The present study investigated the... | Visual Prosthesis; Mobility; Phosphene Simulator | 1992 |